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Preparation method for daunorubicin and 5-bromotetrandrine co-carried magnetic ferrosoferric oxide nanoparticles

The technology of bromohexanone and bromohexanone- is applied in the field of preparation of co-loaded daunorubicin and 5-bromohexanol magnetic nanometer ferric tetroxide particles, which can solve the problem of insufficient effect. Satisfactory and other problems, to achieve the effect of significant effect, prolonged existence time, and high encapsulation rate

Inactive Publication Date: 2012-10-24
SOUTHEAST UNIV
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  • Claims
  • Application Information

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Problems solved by technology

The research on P-gp inhibitors has developed rapidly. It has experienced the first and second generations, and now it has developed to the third generation. The results of multiple clinical trials show that their effects in practical applications are not very satisfactory.

Method used

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  • Preparation method for daunorubicin and 5-bromotetrandrine co-carried magnetic ferrosoferric oxide nanoparticles
  • Preparation method for daunorubicin and 5-bromotetrandrine co-carried magnetic ferrosoferric oxide nanoparticles
  • Preparation method for daunorubicin and 5-bromotetrandrine co-carried magnetic ferrosoferric oxide nanoparticles

Examples

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Embodiment

[0029] Example A co-loaded daunorubicin and 5-bromotetrandrine magnetic nano iron ferric oxide particles as a drug for treating cancer:

[0030] The first step: 26 g FeCl 3 ·6H 2 O and 18 g FeSO 4 ·7H 2 Dissolve O in 50 mL of deionized water, stir with a mechanical stirrer (700-800 rpm) under the protection of nitrogen, in a water bath at 70 °C, slowly drop 50 mL of ammonia water into the iron salt solution, the solution hydrolyzes to produce a large amount of black Fe 3 o 4 Crystal particles, after 5 minutes, add 5g oleic acid, react for 30 minutes, heat up to 80°C and mature for 1 hour, the product is separated with a permanent magnet, washed with deionized water and absolute ethanol several times, and freeze-dried for subsequent use. Weigh the above 450 mg oleic acid-coated Fe 3 o 4 , dissolved in 45 mL of deionized water, added 150 mg of Pluronic F127, stirred magnetically, and left overnight at room temperature. After the product was centrifuged (1000 rpm, 10 ...

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Abstract

The invention discloses a preparation method for daunorubicin and 5-bromotetrandrine co-carried magnetic ferrosoferric oxide nanoparticles, and relates to a preparation process for magnetic drug-loaded nanoparticles. The method comprises the following steps: dissolving ferric sulfate, ferrous sulfate in water according to a certain ratio; adding ammonia water in the presence of nitrogen, and further adding oleic acid; carrying out steps of vigorous stirring, high temperature aging and the like to obtain oleic acid coated ferrosoferric oxide nanoparticles; modifying the resulting ferrosoferricoxide nanoparticles through a proper amount of PluronicF127 to obtain the blank magnetic ferrosoferric oxide nano-carrier; adding the blank magnetic ferrosoferric oxide nano-carrier to a methanol solution comprising daunorubicin and 5-bromotetrandrine, then carrying out steps of vigorous stirring overnight, washing through the water, and magnetic separation to obtain the daunorubicin and 5-bromotetrandrine co-carried magnetic ferrosoferric oxide nanoparticles.

Description

technical field [0001] The invention relates to a preparation process of magnetic nanometer drug-loaded particles used as drugs for treating cancer. Background technique [0002] The present invention relates to a preparation process of a novel magnetic nanometer drug-loaded particle. A chemical co-precipitation method is used to prepare a simultaneously encapsulated chemotherapeutic drug daunorubicin and a P-glycoprotein (P-gp) inhibitor 5-bromohan The magnetic ferric iron tetroxide nanoparticles of tetrandrine, because the encapsulated magnetic iron ferric oxide nanoparticles have superparamagnetism, have magnetic targeting in the alternating magnetic field, and can realize the targeted delivery and release of magnetic nanoparticles At the same time, because the encapsulated magnetic nano-ferric iron tetroxide has magnetic induction heating characteristics in an alternating magnetic field, this new type of magnetic nano drug-loaded particle integrates chemotherapy and hype...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61K31/4748A61K47/02A61K9/16A61P35/00
Inventor 陈宝安王筠吴玮玮蔡晓辉程坚王彩莲张海军王雪梅
Owner SOUTHEAST UNIV
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