Method for purifying ginkgo flavones through membrane separation

A technology of ginkgo flavonoids and purification methods, which is applied in the direction of anti-toxins, medical raw materials derived from gymnosperms, cardiovascular system diseases, etc., can solve the problems of high equipment cost, cumbersome process, and low product purity, and achieve continuous The effects of automation and automation, reduction of environmental pollution, and simple process flow

Inactive Publication Date: 2012-01-04
BEIJING FORESTRY UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional extraction method has complex processing technology, unsatisfactory purification effect, high cost and low benefit, and serious waste of funds and resources.
For example, the process of the solvent method is cumbersome, and the purity of the flavonoid products obtained is not high; although the supercritical fluid extraction method can obtain flavonoid extracts, the equipment cost is high, high-pressure technology is required, and there is still a lack of basic data and methods for equipment and process design. The systematic method is not popular in my country at present; the macroporous resin adsorption method has low energy consumption and simple equipment, but the product purity is not high

Method used

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  • Method for purifying ginkgo flavones through membrane separation
  • Method for purifying ginkgo flavones through membrane separation
  • Method for purifying ginkgo flavones through membrane separation

Examples

Experimental program
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Effect test

Embodiment 1

[0045] Take 300 mg of crude flavonoids and dissolve in 600 mL of ethanol-water with a mass fraction of ethanol of 30%. After filtration, set aside, control the operating pressure at 0.2Mpa, feed liquid temperature at 30°C, select a polyvinylidene fluoride (PVDF) ultrafiltration membrane with a molecular weight cut-off of 500,000dalton for ultrafiltration, ultrafiltration time is 2h, and collect the permeate. After drying the collected permeate, the content of flavonoids was determined. After ultrafiltration, the content of ginkgo flavonoids increased from 24% to 35.2%.

Embodiment 2

[0047] Take 300 mg of crude flavonoids and dissolve in 600 mL of ethanol-water with a mass fraction of ethanol of 30%. After filtration, set aside, control the operating pressure at 0.2Mpa, feed liquid temperature at 40°C, select a polyvinylidene fluoride (PVDF) ultrafiltration membrane with a molecular weight cut-off of 100,000dalton for ultrafiltration, ultrafiltration time is 2h, and collect the permeate. After drying the collected permeate, the content of flavonoids was determined. After ultrafiltration, the content of ginkgo flavonoids increased from 24% to 39.4%.

Embodiment 3

[0049] Take 300 mg of crude flavonoids and dissolve in 600 mL of ethanol-water with a mass fraction of ethanol of 30%. After filtration, set aside, control the operating pressure at 0.25Mpa, feed liquid temperature at 30°C, select a polyacrylonitrile (PAN) ultrafiltration membrane with a molecular weight cut-off of 50,000dalton for ultrafiltration, ultrafiltration time is 2h, and collect the permeate. After drying the collected permeate, the content of flavonoids was determined. After ultrafiltration, the content of ginkgo flavonoids increased from 24% to 40.2%.

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Abstract

The invention relates to a production method for purifying ginkgo flavones by a membrane separation technology. The method is used for refining a ginkgo flavone crude product, and is characterized by comprising the following steps of: adding ethanol solution to dissolve the ginkgo flavone crude product serving as a raw material, pretreating, and making flavone solution permeate a membrane under certain pressure to form flavone solution with high purity. The membrane separation technology comprises an ultrafiltration coupling technology among ultrafiltration membranes of different pore sizes, a nanofiltration coupling technology among nanofiltration membranes of different pore sizes, and a coupling technology between ultrafiltration and nanofiltration. In one embodiment, the membrane can be immersed in a feed liquid kettle, percolate is obtained through suction filtering, and the membrane also can be positioned outside the kettle in different embodiments suitable for flavone treatment.

Description

technical field [0001] The invention relates to a method for refining and purifying ginkgo flavonoids, in particular to a method for purifying ginkgo flavonoids by membrane separation technology. Background technique [0002] Ginkgo biloba Linn. is a perennial deciduous tree of the Ginkgo family (Ginkgeae) and belongs to the gymnosperms of the Mesozoic Jurassic period more than 200 million years ago. Now there is only one family, one genus and one species. Gymnosperms are known as "living fossils". Since ancient times, there have been records of using ginkgo as medicine in my country. It is recorded in "Compendium of Materia Medica" that ginkgo has the effect of "constricting the lungs and relieving asthma, stopping enuresis and leucorrhea". In 1966, scientists from the Federal Republic of Germany first discovered that Ginkgo biloba contains medicinal ingredients that can promote blood circulation and lower cholesterol, and its medicinal value has increasingly attracted the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/15A61P9/00A61P31/12A61P37/04A61P39/06
Inventor 贠延滨向文艺刘旭朱明行王丽华曲丹孙德智
Owner BEIJING FORESTRY UNIVERSITY
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