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Tarragon soup effervescent tablet and its preparation method

The technology of effervescent tablet and Yinchen is applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. It can solve the problems of poor stability of effervescent tablets, and achieve easy storage and easy acceptance. , the preparation method is simple

Inactive Publication Date: 2012-01-11
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention develops the modern preparation technology of traditional Chinese medicine famous prescriptions, makes Yinchen decoction into effervescent tablets, and effectively isolates the contact with the acid agent by using polyethylene glycol to wrap the alkali agent, and solves the problem of effervescent tablets. The problem of poor stability

Method used

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  • Tarragon soup effervescent tablet and its preparation method
  • Tarragon soup effervescent tablet and its preparation method
  • Tarragon soup effervescent tablet and its preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0025] 1. Prescription of Yinchen Decoction Effervescent Tablets (1000 tablets):

[0026]

[0027] 2. The extraction process of Yinchen Decoction extract is as follows:

[0028] Add 8 times the quality of water to capillary herbs, soak for 1 hour, decoct for 1 hour, then add gardenia and rhubarb herbs, add 10 times the quality water of capillary herbs, decoct for 2 hours, let stand for 12 hours, filter, concentrate the filtrate to an appropriate amount, and cool Add ethanol to make the alcohol content reach 80% (volume fraction), filter after standing for 12h, and concentrate the filtrate to obtain Yinchen Decoction extract with a density of 1.5g / ml. The weight ratio of Yinchen: Gardenia: Rhubarb is 70 :17:23.

[0029] 3. The preparation process of Yinchen Decoction effervescent tablets is as follows:

[0030] (1) Add 40g of polyethylene glycol 4000 and 40g of polyethylene glycol 6000 into 150g of sodium bicarbonate and stir evenly, cool, pulverize, and pass through an 80...

Embodiment 2

[0036] 1. Prescription of Yinchen Decoction Effervescent Tablets (1000 tablets):

[0037]

[0038] 2. The extraction process of Yinchen Decoction extract is as follows:

[0039] Take capillary medicinal materials and add 10 times the quality of water, soak for 2 hours, decoct for 2 hours, then add gardenia and rhubarb medicinal materials, add 10 times the quality water of capillary medicinal materials, decoct for 2 hours, let stand for 8 hours, filter, concentrate the filtrate to an appropriate amount, and cool Then add ethanol to make the alcohol content reach 75% (volume fraction), filter after standing for 8 hours, and concentrate the filtrate to obtain Yinchen Decoction extract with a density of 1.3g / ml. The weight ratio of Yinchen: Gardenia: Rhubarb is 70 :17:23.

[0040] 3. The preparation process of Yinchen Decoction effervescent tablets is as follows:

[0041] (1) Add 70 g of polyethylene glycol 4000 to 110 g of sodium carbonate and 100 g of sodium bicarbonate, st...

Embodiment 3

[0047] 1. The prescription of Yinchen Decoction Effervescent Tablets consists of the following components (1000 tablets):

[0048]

[0049] 2. The preparation method of Yinchen Decoction effervescent tablet comprises the following steps:

[0050] (1) Add 100g lubricant to 250g alkali agent, stir evenly, cool, pulverize, cross 100 mesh sieves, get package; Described lubricant is polyethylene glycol 6000, and alkali agent is sodium carbonate (110g), bicarbonate A mixture of sodium (140 g);

[0051] (2) acid agent, filler are crossed 100 mesh sieves respectively; Described acid agent selects tartaric acid, and filler selects mannitol;

[0052] (3) Mix 200g of acid agent, 230g of filler and wrapper, add 120g of Yinchen Decoction extract, and granulate;

[0053] (4) drying after granulation, granulation, spraying into 50g fragrance, then drying, tabletting; described fragrance selects sweet orange essence;

[0054] (5) After passing the inspection, pack it to obtain Yinchen D...

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Abstract

The invention provides a tarragon soup effervescent tablet and its preparation method. According to the invention, traditional Chinese medicinal prescriptions are developed by a modern preparation technology and a decoction of the tarragon soup is prepared into the effervescent tablet. The weight of the prepared tarragon soup effervescent tablet is 1g; the hardness is 5.5-6kg; the disintegration time is 180-190s; after disintegration, the solution is clear with no sediment residue, pH is 5.0-5.5 and the foam volume is 8-9 mL. The prepared effervescent tablet conforms to pharmacopoeia provisions. By a method of wrapping an alkaline agent with the use of polyethylene glycol, the alkaline agent is effectively isolated from an acid inhibitor, and the problem of poor stability of the effervescent tablet is solved. In addition, the preparation technology is simple; the prepared effervescent tablet is not easy to absorb moisture, has a non-deformable appearance and a good taste, and is rapidto dissolve and convenient to store, transport and carry.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to Yinchentang effervescent tablets and a preparation method thereof. Background technique [0002] Yinchenhao Decoction, also known as Yinchen Decoction, comes from "Treatise on Febrile and Miscellaneous Diseases". The prescription is composed of 700g Yinchen, 170g Gardenia, and 230g Rhubarb. It can clear away heat and dampness, detoxify and reduce jaundice. Modern pharmacological studies have shown that Yinchen Decoction has the functions of promoting gallbladder, protecting liver, antipyretic, anti-inflammatory, analgesic, antibacterial and antiviral. Promoting gallbladder and protecting liver is the main pharmacological basis of our prescription for clinical treatment of various jaundice and infectious hepatitis, acute hepatitis, acute viral hepatitis and severe hepatitis. The traditional Yinchen decoction has a large oral dose and a bitter taste. It is inconvenient to ...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61K47/34A61K9/46A61P1/16
Inventor 齐香君李雅余阳李楠
Owner SHAANXI UNIV OF SCI & TECH
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