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Mometasone furoate gel and preparation method thereof

A technology of mometasone furoate and gel is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, which can solve the problems of strong greasy feeling and poor stability, and achieve strong adhesion. , good stability, convenient storage effect

Active Publication Date: 2012-12-12
华润三九(南昌)药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the stability of the mometasone furoate gel sold in the market is generally poor, and most of the products sold in the market are cream preparations, and there are many factors affecting the stability of the cream matrix, and the cream preparation is more prone to delamination. In terms of stability, gel preparations are more stable than cream preparations; in addition, in terms of convenience and greasy feeling, the cream base is composed of an oil phase and a water phase, and the oil phase is mostly petrolatum, fatty acids, and fatty alcohols. , strong greasy feeling when using

Method used

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  • Mometasone furoate gel and preparation method thereof
  • Mometasone furoate gel and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0026] Embodiment 1, mometasone furoate gel, made of the raw and auxiliary materials of the following weight ratio: 1 part of mometasone furoate, 150 parts of glycerin, 7.5 parts of carbomer, 1 part of sodium alginate, laurocaprolactone 5 parts, 10 parts of triethanolamine, 50 parts of medicinal ethanol, 2 parts of ethylparaben, and the remaining amount of purified water to make the total weight 1000 parts.

[0027] Wherein, the preparation method of mometasone furoate gel is:

[0028]1. Disperse carbomer and sodium alginate in an emulsification pot filled with purified water about 50% of the total amount prepared, stir for 1 hour at a speed of 60 rpm, and then place it for 12 hours Fully swell; add glycerin and laurocaprazine to the above solution, stir for 0.5 hours at a speed of 60 rpm, then slowly add triethanolamine to the above solution, and stir at a speed of 60 rpm Stir for 1 hour until it becomes a transparent gel matrix; 2. Add mometasone furoate and ethyl paraben t...

Embodiment 2

[0029] Embodiment 2, mometasone furoate gel, made of the raw and auxiliary materials in the following weight ratio: 1 part of mometasone furoate, 150 parts of glycerin, 7.5 parts of carbomer, 1 part of sodium alginate, laurocaprolactone 5 parts, 10 parts of triethanolamine, 50 parts of medicinal ethanol, 2 parts of ethylparaben, and the remaining amount of purified water to make the total weight 1000 parts.

[0030] The preparation method of mometasone furoate gel is:

[0031] 1. Disperse carbomer and sodium alginate in an emulsification pot filled with purified water about 50% of the total amount prepared, stir for 1 hour at a speed of 60 rpm, and then place it for another 16 hours Fully swell; add glycerin and laurocaprazine to the above solution, stir for 0.5 hours at a speed of 60 rpm, then slowly add triethanolamine to the above solution, and stir at a speed of 60 rpm Stir for 1 hour until it becomes a transparent gel matrix; 2. Add mometasone furoate and ethyl paraben t...

Embodiment 3

[0032] Embodiment 3, mometasone furoate gel, made of the raw and auxiliary materials of the following weight ratio: 1 part of mometasone furoate, 130 parts of glycerin, 9.5 parts of carbomer, 10 parts of triethanolamine, 50 parts of medicinal ethanol , 2 parts of ethylparaben, and the purified water that adds balance to total weight is 1000 parts.

[0033] The preparation method of mometasone furoate gel is:

[0034] 1. Disperse carbomer and sodium alginate in an emulsification pot filled with purified water about 50% of the total amount prepared, stir for 1 hour at a speed of 60 rpm, and then place it for another 10 hours Fully swell; add glycerin and laurocaprazine to the above solution, stir for 0.5 hours at a speed of 60 rpm, then slowly add triethanolamine to the above solution, and stir at a speed of 60 rpm Stir for 1 hour until it becomes a transparent gel matrix; 2. Add mometasone furoate and ethylparaben to medicinal ethanol, stir to dissolve, heat in a water bath to...

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Abstract

The invention provides mometasone furoate gel and a preparation method thereof; the mometasone furoate gel is prepared by the following raw auxiliary materials by weight: 1 parts of mometasone furoate, 150 parts of glycerin, 7.5 parts of carbomer, 1 parts of sodium alginate, 5 parts of laurocapram, 10 parts of triethanolamine, 50 parts of medicinal ethanol, 2 parts of ethylparaben, and the balance of purified water which is added to allow the total weight to be 1000 parts; The advantages of the invention are that: carbomer is used as a water-soluble substrate; triethanolamine is used as a consistency regulator; the product is provided with the advantages of strong adhesion to skin surfaces, good spreading performance, prolongation of retention time of the medicament on skin surfaces; and the effect of the medicament is enhanced. The product is easy to spread and wash, is not greasy, can absorb tissue exudates, and does not interfere normal functions of skin. The product is easy to clean, does not contaminate clothes, and has good stability; the product has smooth appearance, and is transparent and fine; the product has no local irritation; the product has appropriate consistency and viscosity, and is easy to be coated for application; the product has the advantages of convenient carrying, transportation, and storage.

Description

technical field [0001] The present invention relates to the technical field of a kind of external preparation medicine, especially a kind of external use gel preparation medicine containing mometasone furoate, because this gel adopts the matrix combination of carbomer and triethanolamine, carbomer is used as the gel matrix , triethanolamine as a consistency regulator, glycerin as a humectant, has better moisturizing and stability, can absorb tissue exudate without hindering the normal function of the skin, especially suitable for seborrheic skin diseases. Background technique [0002] Mometasone furoate is a synthetic local glucocorticoid drug, which has the characteristics of strong curative effect and low inhibition of adrenal cortex function. Mometasone furoate gel has the effect of reducing inflammation and itching, suitable for skin diseases that are effective to glucocorticoids such as dermatitis (contact dermatitis, seborrheic dermatitis, atopic dermatitis, neuroderma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K31/58A61K47/36A61P17/00A61P17/06
Inventor 李军吴泽榕徐玉琴艾毛涛袁阳亮
Owner 华润三九(南昌)药业有限公司
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