Preparation method of Baoxin tablet

A technology of Baoxin tablets and diaphragm pressure filtration, which can be applied to medical preparations containing active ingredients, pharmaceutical formulations, cardiovascular system diseases, etc., and can solve the problems of cumbersome process, high energy consumption, and troublesome post-processing.

Active Publication Date: 2012-01-18
TAIJI GRP CHONGQING FULING PHARM FACTORY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the above methods, the active ingredients of prescription medicinal materials are extracted by percolation, reflux, and decoction methods, but there are cumbersome processes, long extraction time, high extraction temperature, high energy consumption, easy loss of heat-sensitive ingredients, low recovery rate of active ingredients, and post-processing. Disadvantages such as handling trouble

Method used

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  • Preparation method of Baoxin tablet
  • Preparation method of Baoxin tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Prescription: Sanqi 450g, Danshen 5.4kg, Chuanxiong 3.6kg, Hawthorn 4.5kg, Polygonum multiflorum 1.575kg, Polygonum multiflorum 2.925kg

[0045] The preparation method comprises the following steps:

[0046] a. Extraction of Polygonum multiflorum

[0047] a1. Crush the Polygonum Polygoni Multiflori in the prescribed amount into a coarse powder and set aside;

[0048] a2. Add 60% ethanol equivalent to 7 times the weight of Polygonum multiflorum in the batching tank; switch the three-way valve to the batching tank position, open the agitator, diaphragm pump and diaphragm filter press of the batching tank, pump the 60% ethanol in the batching tank into the membrane filter press (using 5-8 L / m 2 .s polypropylene multifilament filter cloth), until the filtrate returns to the batching tank, add the powder obtained in step a1 into the batching tank at a constant speed, after the addition, the membrane filter press cycle extracts for 30 minutes, and then switch the three-w...

Embodiment 2

[0062] Prescription: Sanqi 450g, Danshen 5.4kg, Chuanxiong 3.6kg, Hawthorn 4.5kg, Polygonum multiflorum 1.575kg, Polygonum multiflorum 2.925kg

[0063] The preparation method comprises the following steps:

[0064] a. Extraction of Polygonum multiflorum

[0065] a1. Crush the Polygonum Polygoni Multiflori in the prescribed amount into a coarse powder and set aside;

[0066] a2. Add 60% ethanol equivalent to 6 times the weight of Polygonum multiflorum in the batching tank; switch the three-way valve to the batching tank position, open the agitator, diaphragm pump and diaphragm filter press of the batching tank, pump the 60% ethanol in the batching tank into the membrane filter press (using 5-8 L / m 2 .s polypropylene multifilament filter cloth), when the press filtrate flows back into the batching tank, add the medicine powder obtained in step a1 into the batching tank at a constant speed, after the addition is completed, the membrane filter press cycle extracts for 40 minu...

Embodiment 3

[0080] Prescription: Sanqi 450g, Danshen 5.4kg, Chuanxiong 3.6kg, Hawthorn 4.5kg, Polygonum multiflorum 1.575kg, Polygonum multiflorum 2.925kg

[0081] The preparation method comprises the following steps:

[0082] a. Extraction of Polygonum multiflorum

[0083] a1. Crush the Polygonum Polygoni Multiflori in the prescribed amount into a coarse powder and set aside;

[0084] a2. Add 60% ethanol equivalent to 8 times the weight of Polygonum multiflorum in the batching tank; switch the three-way valve to the batching tank position, open the agitator, diaphragm pump and diaphragm filter press of the batching tank, pump the 60% ethanol in the batching tank into the membrane filter press (using 5-8 L / m 2 .s polypropylene multifilament filter cloth), when the press filtrate flows back into the batching tank, add the medicinal powder obtained in step a1 into the batching tank at a constant speed, after the addition is completed, the membrane filter press cycle extracts for 35 min...

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Abstract

The invention discloses a preparation method of a Baoxin tablet. The preparation method adopts a diaphragm press filtration cycle extraction separation integrated technology to replace the existing percolation method and ethanol reflux to extract active ingredients of prescription drugs. Therefore, the preparation method simplifies a process flow, shortens greatly a production period, saves energy consumption, is beneficial for environmental protection, reduces a use amount of ethanol as an extracting solvent, and improves greatly an active ingredient recovery rate.

Description

technical field [0001] The invention belongs to the field of pharmacy and relates to a preparation method of a traditional Chinese medicine preparation. Background technique [0002] The 2010 edition of Chinese Pharmacopoeia records: Baoxin Tablet has the effects of nourishing the liver and kidney, promoting blood circulation and removing blood stasis. It is clinically used for chest pain known as liver and kidney deficiency, blood stasis and inner stop. Symptoms include chest tightness and precordial tingling; Heart disease angina pectoris see the above syndrome. The prescription is 45g of Panax notoginseng, 540g of Salvia miltiorrhiza, 360g of Chuanxiong, 450g of hawthorn, 157.5g of Polygonum multiflorum, and 292.5g of Polygonum multiflorum. Its preparation method is to crush Radix Notoginseng and Radix Polygoni Multiflori into fine powder, and mix well; Radix Polygoni Multiflori into coarse powder, use 70% ethanol as solvent, soak for 24 hours, slowly infiltrate, and col...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/734A61K9/20A61P9/10
Inventor 冯天炯刘伟霞喻贵英郭平牯
Owner TAIJI GRP CHONGQING FULING PHARM FACTORY CO LTD
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