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Synthesizing method of amorphous calcium phosphate

A synthesis method and technology of crystalline calcium phosphate, applied in phosphorus compounds, chemical instruments and methods, non-metallic elements, etc., to achieve the effects of simple and easy process operation, simple equipment and mild conditions

Inactive Publication Date: 2012-01-18
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At home and abroad, there are many studies on the preparation of apatite with ACP as the intermediate phase or transition product, but there are few reports on the synthesis of ACP powder.

Method used

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  • Synthesizing method of amorphous calcium phosphate
  • Synthesizing method of amorphous calcium phosphate
  • Synthesizing method of amorphous calcium phosphate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A kind of synthetic method of ACP, the steps are as follows:

[0027] (1) Take by weighing calcium nitrate tetrahydrate (Ca(NO 3 ) 2 4H 2 O) 5.9g, diammonium hydrogen phosphate ((NH 4 ) 2 HPO 4 ) 1.98g; then the weighed Ca(NO 3 ) 2 4H 2 O is dissolved in 250ml absolute ethanol solution and is made into solution A, the (NH 4 ) 2 HPO 4 Dissolve in a mixed solution of 100ml of absolute ethanol and 200ml of deionized water to form solution B; stir solution A at a constant temperature at 0°C (ice-water mixture) and solution B at room temperature;

[0028] (2) The concentration of calcium ions in solution A is 0.1mol / L, and the concentration of phosphate ions in solution B is 0.01mol / L; add ammonia water in solution A to adjust the pH to 11.5 to obtain solution C, add ammonia water in solution B Adjust the pH to 11.5 to obtain solution D;

[0029] (3) Place solution C in an ultrasonic environment at 0°C (in an ultrasonic generator, using a water bath, the ultrason...

Embodiment 2

[0033] (1) Take by weighing calcium nitrate tetrahydrate (Ca(NO 3 ) 2 4H 2 O) 5.9g, diammonium hydrogen phosphate ((NH 4 ) 2 HPO 4 ) 1.98g; then the weighed Ca(NO 3 ) 2 4H 2 O is dissolved in 100ml absolute ethanol solution and is made into solution A, the (NH 4 ) 2 HPO 4 Dissolve in a mixed solution of 80ml of absolute ethanol and 100ml of deionized water to form solution B; stir solution A at a constant temperature at 0°C (ice-water mixture) and solution B at room temperature;

[0034] (2) The amount of calcium ions in solution A is 0.25mol / L, and the amount of phosphate ions in solution B is 0.083mol / L; add ammonia water in solution A to adjust the pH to 11.5 to obtain solution C, add ammonia water in solution B Adjust the pH to 11.5 to obtain solution D;

[0035] (3) Place solution C in an ultrasonic environment at 0°C (in an ultrasonic generator, using a water bath, the ultrasonic electric power is 250W, and the operating frequency is 40KHZ), and use a separato...

Embodiment 3

[0039] (1) Take by weighing calcium nitrate tetrahydrate (Ca(NO 3 ) 2 4H2 O) 5.9g, diammonium hydrogen phosphate ((NH 4 ) 2 HPO 4 ) 1.98g; then the weighed Ca(NO 3 ) 2 4H 2 O is dissolved in 50ml absolute ethanol solution and is made into solution A, the (NH 4 ) 2 HPO 4 Dissolve in 30ml deionized water to make solution B; stir solution A at constant temperature at 0°C (ice-water mixture) and solution B at room temperature;

[0040] (2) The amount of calcium ions in solution A is 0.5mol / L, and the amount of phosphate ions in solution B is 0.5mol / L; add ammonia water in solution A to adjust the pH to 11.5 to obtain solution C, add ammonia water in solution B Adjust the pH to 11.5 to obtain solution D;

[0041] (3) Place solution C in an ultrasonic environment at 0°C (in an ultrasonic generator, using a water bath, the ultrasonic electric power is 300W, and the operating frequency is 35KHZ), and drop solution D into solution C with a separatory funnel, Stir solution C ...

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Abstract

The invention relates to a synthesizing method of amorphous calcium phosphate (ACP). According to the invention, tetrahydrated calcium nitrate and diammonium hydrogen phosphate are prepared into a solution; the solution is precipitated under an ultrasonic condition with a temperature of 0 DEG C; and the precipitate is vacuum-filtered and is dried, such that ACP powder is obtained. According to the method, no stabilizer is needed, and the method is simple and applicable. With the method, calcium phosphate powder with an adjustable Ca / P ratio and good bioactivity can be prepared. The prepared ACP powder can be applied in the field of biomedical materials.

Description

technical field [0001] The invention relates to a method for synthesizing amorphous calcium phosphate (ACP for short), in particular to a method for synthesizing ACP used in the fields of biomedical materials and the like. Background technique [0002] ACP is an intermediate transition phase formed during the synthesis of hydroxyapatite, which has a high biodegradation rate, no cytotoxicity, and good biological activity. Therefore, it has a wide range of applications and good development prospects in the fields of medical implant materials, tissue engineering and drug controlled release. [0003] Since ACP is unstable in aqueous solution and is easy to transform into crystalline apatite, in the prior art, ACP is mostly prepared by adding a stabilizer. Such as Chinese invention patent (publication number is CN1935636, publication date is 2007.03.28) "a kind of preparation method of nanometer amorphous calcium phosphate powder", take phosphorus source compound and calcium sou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32
Inventor 吕宇鹏何坤焦燕肖桂勇
Owner SHANDONG UNIV
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