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Liquid-phase synthesis method of silver-chitosan and/or chitosan derivative nanocomposite

A technology of chitosan derivatives and nanocomposites, which is applied in the direction of drug combinations, inorganic active ingredients, and medical preparations of non-effective ingredients. It can solve the problems of preparation methods and applications that have not been reported, and achieve the effect of uniform particle size.

Inactive Publication Date: 2012-01-25
LIAOCHENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation method and application of silver-chitosan and its derivatives nanocomposite powder with chitosan and its derivatives as carrier, dispersant and protective agent have not been reported

Method used

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  • Liquid-phase synthesis method of silver-chitosan and/or chitosan derivative nanocomposite
  • Liquid-phase synthesis method of silver-chitosan and/or chitosan derivative nanocomposite

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] A kind of silver, chitosan nanocomposite, preparation method step is as follows:

[0055] (1) Grind 10g chitosan into fine powder;

[0056] (2) Grinding 0.005g of silver nitrate into fine powder;

[0057] (3) Mix chitosan fine powder and silver nitrate fine powder, and grind thoroughly for 1 hour;

[0058] (4) Add 0.005 g of ascorbic acid, and continue to fully grind for 2 hours to obtain a silver-chitosan nanocomposite (sample 1) with a silver particle size of 1-100 nm.

Embodiment 2

[0060] A nanocomposite of silver and chitosan derivatives, the preparation method steps are as follows:

[0061] (1) Grinding 10g carboxymethyl chitosan into fine powder;

[0062] (2) Grinding 0.005g of silver nitrate into fine powder;

[0063] (3) Mix carboxymethyl chitosan fine powder with silver nitrate fine powder and grind them thoroughly for 2 hours;

[0064] (4) Add 0.005 g of glucose and continue to grind thoroughly for 2.5 hours to obtain a silver-chitosan derivative nanocomposite (sample 2) with a silver particle size of 1-100 nm.

Embodiment 3

[0066] A nanocomposite of silver, chitosan and chitosan derivatives, the preparation method steps are as follows:

[0067] (1) Grind 7g chitosan and 3g hydroxypropyl chitosan into fine powder;

[0068] (2) Grinding 0.005g of silver nitrate into fine powder;

[0069] (3) Mix chitosan and hydroxypropyl chitosan fine powder with silver nitrate fine powder, and fully grind for 2 hours;

[0070] (4) Add 0.005 g of N-acetylglucosamine, and continue to fully grind for 6 hours to obtain silver, chitosan and chitosan derivative nanocomposites with a silver particle size of 1-100 nm.

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Abstract

The invention discloses a liquid-phase synthesis method of silver-chitosan and / or chitosan derivative nanocomposite. The obtained product has the functions of promoting wound surface healing, arresting bleeding, relieving pain, resisting inflammation and sterilizing bacteria, is suitable for female vaginitis, cervicitis, cervical erosion, bedsore, dermal ulcer, burn, scald, trauma, other skin phlogosis, tinea of feet and hands and the like, and can also be used for preparing various trauma dressings such as thin films, sponges, suppositories for gynecology, application films and the like.

Description

[0001] This application is a divisional application: original application number: 200910017600.8, filing date: 2009.8.11, invention name: preparation method and application of nanocomposite of silver, chitosan and / or its derivatives. technical field [0002] The invention relates to the technical fields of chemical industry and medicine, in particular to a preparation method of silver, chitosan and / or chitosan derivative nanocomposite powder and its application in the treatment of female vaginitis, cervicitis, cervical erosion, bedsore, skin Ulcers, burns, scalds, wounds, and other skin inflammations, tinea pedis and other pharmaceutical applications, and can also be used to prepare various trauma dressings such as films, sponges, gynecological suppositories, films, etc. Background technique [0003] Chitosan is the deacetylation product of chitin, and it is a basic amino polysaccharide existing in nature. In recent years, studies by scholars at home and abroad have shown th...

Claims

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Application Information

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IPC IPC(8): A61K33/38A61K9/02A61K9/70A61K47/36A61L15/28A61L15/44A61P15/00A61P15/02A61P17/00A61P17/02A61P31/04A61P31/10
Inventor 桑青秦东风
Owner LIAOCHENG UNIV
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