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Anisotropic nanometer press-in test table of biological soft tissues and method for performing nanometer press-in experiment by using anisotropic nanometer press-in test table

A biological soft tissue and nano-indentation technology, applied in the field of nano-indentation experiment and anisotropic nano-indentation test bench of biological soft tissue, can solve the problem that the biological activity of the material cannot be well guaranteed for a long time, the water loss of the tested surface, and the impact Experiment reliability and other issues, to achieve the effect of improving the efficiency of detection experiments, avoiding water loss, and improving the reliability of detection

Inactive Publication Date: 2012-02-01
BEIJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are many problems in the nanoscale mechanical testing of biological soft tissues. The first problem is the preparation and clamping of materials. Usually, the sample preparation methods used for soft samples are mainly direct bonding and cold mounting. The biological soft tissue is bonded on the sample platform, which has the advantages of high experimental efficiency and a short time for preparing the sample. However, the adhesive used for bonding will dehydrate the experimental materials to varying degrees. Muscles, blood vessels, etc. have become parchment-like and separated from the test bench, which not only affects the reliability of the experiment but also increases the error
Cold mounting ensures that the biological material can be in good contact with the sample stage and prevents the misalignment of the material during the press-in process. Dehydration of biological materials makes the measured hardness and elastic modulus higher than the mechanical properties of the material itself
It is difficult to carry out moisture retention experiments on materials in cold mounting, which makes the measured surface lose water and affects the reliability of the measurement

Method used

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  • Anisotropic nanometer press-in test table of biological soft tissues and method for performing nanometer press-in experiment by using anisotropic nanometer press-in test table
  • Anisotropic nanometer press-in test table of biological soft tissues and method for performing nanometer press-in experiment by using anisotropic nanometer press-in test table
  • Anisotropic nanometer press-in test table of biological soft tissues and method for performing nanometer press-in experiment by using anisotropic nanometer press-in test table

Examples

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Effect test

example 1

[0032] The test material is a large piece of cartilage on the lamb leg bone plate. The pressing direction is perpendicular to the natural surface of the cartilage. The test material is cut into a 15mm diameter disc as a test sample, and a drop of moisturizing solution is dropped into the holding hole 2 of the test platform. , spread the test sample on the bottom of the storage hole 2, drop a drop of solution, then use the screw cap body 3 with a round hole observation window 4 to press the test sample, and adjust the screw cap body 3 with a dropper through the observation window 4 The height of the inner solution, and then put the whole test bench into the card stage of the nanoindenter. The indenter used for indentation is the Flat end cone indenter produced by Agilent, the surface proximity sensitivity coefficient is 40%, and the indentation depth is 5000nm. The obtained results are as follows Figure 9 shown.

Embodiment 2

[0034]The test material is a large piece of cartilage on the bone plate of the leg of lamb. The pressing direction is perpendicular to the longitudinal cutting surface of the natural surface of the cartilage. The test material is cut into 6mmX15mm strip-shaped slices with a microtome as the test sample. Drop a drop of moisturizing solution into the hole 2, spread the test sample on the bottom of the storage hole 2, drop another drop of solution, then use the screw cap body 3 with a rectangular observation window 4 to press the test sample, and pass through the observation window 4 Use a dropper to adjust the height of the solution in the screw cap body 3, and then install the whole test platform on the card platform of the nanoindentation instrument. The indenter used for indentation is the Flat end cone indenter produced by Agilent, the surface proximity sensitivity coefficient is 40%, and the indentation depth is 5000nm. The obtained results are as follows Figure 10 shown. ...

Embodiment 3

[0036] The test material is bovine cardiovascular, and the pressing direction is perpendicular to the inner surface of the heart tube. The test material is cut into a 15mm diameter disc as a test sample. Since the heart tube is thin, a non-porous aluminum sheet with a thickness of 2mm is used as a gasket before spinning. Put the heart tube sample into the holding hole 2, drop a drop of moisturizing solution into the holding hole 2 of the detection platform, spread the test sample on the bottom of the holding hole 2, and then drop a drop of the solution, Then use the screw cap body 3 with a circular observation window 4 to press the test sample, adjust the height of the solution in the screw cap body 3 through the observation window 4 with a dropper, and then put the whole test platform into the card platform of the nanoindentation instrument . The indenter used for indentation is the Flat end cone indenter produced by Agilent, the surface proximity sensitivity coefficient is 1...

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Abstract

The invention discloses an anisotropic nanometer press-in test table of biological soft tissues and a method for performing a nanometer press-in experiment by using the anisotropic nanometer press-in test table. The anisotropic nanometer press-in test table of the biological soft tissues comprises a table body, wherein an accommodation hole which accommodates a test sample is formed in the middle of the upper part of the table body; two screwing cover bodies which spirally screw in the accommodation hole and cover the top of the accommodation hole are arranged on the upper part of the table body and pressed against the test sample; observation holes are formed in the screwing cover bodies; the observation holes in the screwing cover bodies respectively are circular and rectangular; and a humidity-preserving solution which preserves the humidity of the test sample can be dripped into the accommodation hole. By adoption of the anisotropic nanometer press-in test table of the biological soft tissues, the loss of the surface moisture of the test sample is avoided, the credibility of a detection experiment is improved, the error of the detection experiment is reduced, and the efficiency of the detection experiment is improved.

Description

technical field [0001] The invention relates to a test bench, in particular to an anisotropic nano-indentation test bench for biological soft tissue [0002] The present invention also relates to a method for performing a nano-indentation experiment using the above test bench. Background technique [0003] At present, nanoscale mechanical performance testing has become a powerful tool for testing the mechanical properties of biomaterial microstructures, and has been widely used in the research of mechanical properties of microstructures such as teeth and bones. However, there are many problems in the nanoscale mechanical testing of biological soft tissues. The first problem is the preparation and clamping of materials. Usually, the sample preparation methods used for soft samples are mainly direct bonding and cold mounting. The biological soft tissue is bonded on the sample platform, which has the advantages of high experimental efficiency and a short time for preparing the...

Claims

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Application Information

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IPC IPC(8): G01N1/36G01N3/02
Inventor 杨庆生刘志远高雪玉时光辉
Owner BEIJING UNIV OF TECH
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