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Preparation method of hydrogel for drug-loaded contact lens

A contact lens and hydrogel technology, applied in medical science, glasses/goggles, instruments, etc., can solve the problems of lower production efficiency, long polymerization time, high polymerization temperature, etc., and achieve great social and economic benefits, The effect of strong operability and simple synthesis route

Active Publication Date: 2012-02-08
广州鲸盾网络科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Higher polymerization temperature and longer polymerization time reduce production efficiency and increase cost during hydrogel preparation
In addition, as a drug carrier, higher polymerization temperature and longer polymerization time tend to denature some active drugs

Method used

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  • Preparation method of hydrogel for drug-loaded contact lens
  • Preparation method of hydrogel for drug-loaded contact lens
  • Preparation method of hydrogel for drug-loaded contact lens

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Take HEMA 4.7g, NVP 4.7g, add 1.2wt% APS aqueous solution and 0.6wt% TEMED aqueous solution 1mL each, add norfloxacin or hyaluronic acid according to the ratio of 2mg / g monomer, mix well and put Polymerize at 60°C for a certain period of time and copolymerize in a circular mold to prepare a hydrogel. Observing reaction system by observation method becomes the time of hard, transparent film by liquid, i.e. polymerization time (the polymerization time of this example and other each embodiment see figure 1 ). After the polymerization is completed and demolded, it swells into a hydrogel in water.

Embodiment 2

[0030] Take HEMA 3.1g, NVP 6.3g, add 1.2wt% APS aqueous solution and 0.6wt% TEMED aqueous solution 1mL each, add norfloxacin or hyaluronic acid according to the ratio of 2mg / g monomer, mix well and put Hydrogels were prepared by copolymerization in a circular mold at 60°C for a certain period of time. Observe the time for the reaction system to change from a liquid to a hard, transparent film by observation, that is, the polymerization time. After the polymerization is completed and demolded, it swells into a hydrogel in water.

Embodiment 3

[0032] Take HEMA 7.4g, NVP 2g, add 1.2wt% APS aqueous solution and 0.6wt% TEMED aqueous solution 1mL each, add norfloxacin or hyaluronic acid according to the ratio of 2mg / g monomer, mix well and place in 60 Polymerize at ℃ for a certain period of time and copolymerize in a circular mold to prepare hydrogel. Observe the time for the reaction system to change from a liquid to a hard, transparent film by observation, that is, the polymerization time. After the polymerization is completed and demolded, it swells into a hydrogel in water. Put the prepared copolymer hydrogel in a 1.5ml centrifuge tube, add distilled water to 1.5ml, place the centrifuge tube at 37°C, and set the temperature at 3h, 6h, 9h, 12h, 1d, 2d, 3d, 4d respectively , 5d, 6d, and 7d were used to quantify the concentration of the drug (norfloxacin or hyaluronic acid) in the water by ultraviolet light to characterize the performance of drug sustained release.

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PUM

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Abstract

The invention discloses a preparation method of hydrogel for drug-loaded contact lenses, which comprises the following steps: mixing polymeric monomers of hydroxyethyl methacrylate and N-vinyl pyrrolidone, an initiator, and drugs loaded by contact lenses, performing polymerization, after the reaction, swelling in water to obtain hydrogel; wherein the initiator is ammonia sulfate and tetramethyl ethylenediamine. The synthetic route provided by the invention is simple, and is strong in operability; the obtained product has performance which meets basic requirements for contact lenses, and can control the release of hydrophilic eye medicine and hydrophobic eye medicine. The invention has great social benefit and economic benefit.

Description

technical field [0001] The invention belongs to the technical field of new materials, and in particular relates to the preparation of a drug-loaded contact lens hydrogel. Background technique [0002] Eye diseases seriously affect human health and quality of life. Currently, eye diseases are mainly treated with drugs. In drug therapy, a drug concentration that is too low cannot play a therapeutic role; a drug concentration that is too high will cause side effects and even damage normal tissues and organs. The treatment of eye diseases is a slow process, and the efficacy of drugs depends on whether a reasonable drug concentration can be maintained in the diseased part for a sufficient time. Among the currently used ophthalmic preparations, more than 90% are eye drops or eye ointments, which stay in the eyes for only about 2 minutes, and only 1-7% of the drugs can be effectively used. Most of the drugs are discharged through the nasolacrimal duct or The nasal cavity enters ...

Claims

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Application Information

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IPC IPC(8): C08F220/28C08F226/10C08F4/40C08J3/075A61L31/16G02C7/04
Inventor 胡小红邱杰张国俊刘理
Owner 广州鲸盾网络科技有限公司
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