Qinglongyi active extract, its preparation method and its application

An extract, Qinglong technology, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of insignificant overall curative effect, small dosage, low toxic and side effects, etc., achieve good anti-cancer effect, small toxic and side effects, improve Effects of immune function

Active Publication Date: 2012-03-14
HEILONGJIANG ZBD PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are reports about the anticancer activity of Qinglongyi extract, it is only for a single part, but the overall curative effect is not significant. As we all know, cancer brings not only tumor enlargement, metastasis, and spread to patients, but also a The exhaustion of the whole body, unbearable pain, low immunity, toxic and side effects of radiotherapy and chemotherapy, etc. can all cause death. It is urgent to invent an anticancer drug with significant curative effect, low toxic and side effects, small dosage, and can effectively regulate systemic symptoms. anticancer drugs

Method used

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  • Qinglongyi active extract, its preparation method and its application
  • Qinglongyi active extract, its preparation method and its application
  • Qinglongyi active extract, its preparation method and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Example 1: Preparation of Qinglongyi Active Extract Oral Liquid

[0086] Step 1: Preparation of Qinglongyi active extract

[0087] (1) Take 3000g of Qinglongyi, crush it as appropriate, add 10 times the amount of 50% ethanol, carry out percolation extraction, and extract the dregs for later use; depressurize the extract at 60°C and recover ethanol to obtain Qinglong ointment. ethanol extraction crude extract;

[0088] (2) Add 7, 5, and 4 times the decoction of the spare dregs in (1) to extract 3 times, each time for 2, 1, and 0.5 hours respectively, combine the decoction, and condense it into a clear paste with a relative density of 1.08 , add ethanol to make the alcohol content reach 80%, place at 6°C for 48 hours, take out and filter, the filtrate is set aside, and the precipitate is set aside; carry out secondary alcohol precipitation in the same way, and the filtrates are combined for set use, and the precipitate is set aside;

[0089] (3) Dissolve the Qinglongyi cr...

Embodiment 2

[0095] Embodiment 2: Preparation of Qinglongyi active extract granules

[0096] Step 1: Preparation of Qinglongyi active extract

[0097] (1) Take 3000g of Qinglongyi and pulverize it, add 6, 5, 5 times the amount of 95% ethanol to reflux and extract 3 times, each time for 3, 2, and 1 hour, combine the extracts, and extract the dregs for later use; at 40°C Recover the ethanol from the extract under reduced pressure to obtain Qinglongyi crude extract;

[0098] (2) Add 10 and 8 times water decoction to the spare dregs in (1) to extract twice, each time for 3 and 1.5 hours, combine the water decoction, condense into a clear paste with a relative density of 1.25, add ethanol to make the The alcohol content reaches 60%, put it at 4°C for 12 hours, take out and filter, the filtrate is set aside, and the precipitate is set aside; carry out secondary alcohol precipitation in the same way, and the filtrates are combined for set use, and the precipitate is set aside;

[0099] (3) Mix ...

Embodiment 3

[0105] Embodiment 3: the preparation of Qinglongyi active extract pill

[0106] Step 1: Preparation of Qinglongyi active extract

[0107] (1) Take 3000g of Qinglongyi and pulverize it, add 12 times the amount of 65% ethanol, carry out ultrasonic circulation extraction for 3 hours, filter, and extract the dregs for later use; depressurize the extract at 55°C to recover ethanol to obtain clear ointment, namely The crude extract of Qinglongyi ethanol extraction was obtained;

[0108] (2) Add 8 times the water to the spare dregs in (1), ultrasonically extract 2 times at 60°C, each time for 1.5 and 1 hour, combine the extracts, concentrate them into a clear ointment with a relative density of 1.18, add ethanol to make the alcohol content up to 75%, put it at 5°C for 24 hours, take it out and filter, the filtrate is set aside, and the precipitate is set aside;

[0109] (3) Dissolve the crude extract of Qinglongyi alcohol obtained in (1) with water, apply the sample, and pass throu...

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Abstract

The invention relates to a Chinese traditional medicine active extract, a preparation method thereof and an application thereof, particularly relates to an effective part extracted from a Chinese traditional medicine Qinglongyi, its preparation method and its application. The Qinglongyi active extract is prepared by the following steps of ethanol diacolation, reflux, ultrasonic extraction, CO2 supercritical extraction, ethanol precipitation, elution, interception, reflux, concentration, dryness and the like. According to the invention, the anticancer activity of the Qinglongyi effective part is taken as an index for screening the effective part of Qinglongyi, efficacy tests are carried out by using the extract with different contents, the result proves that an effective component in the Qinglongyi active extract for treating cancer is total naphthoquinone; the efficacy test result proves that an effective component for anti-inflammatory analgesic effect is total flavonoid, total tannin and polar micromolecules; a substrate for improving immune function is polysaccharide.

Description

technical field [0001] The invention relates to an active extract of traditional Chinese medicine and its preparation method and application, in particular to an effective part extracted from the traditional Chinese medicine Qinglongyi, its preparation method and application. Background technique [0002] According to the report of the World Health Organization, in 2000, there were 10.1 million new cancer patients worldwide, 6.2 million deaths, and 22.4 million cancer cases. Global cancer is still on the rise, according to the World Health Organization (WHO) experts predict that the total global population will reach 8 billion in 2020, new cancer cases will reach 20 million, and 12 million people will die of cancer. There are 2.2 million new cancer cases and 1.6 million cancer deaths in China every year. In the past 20 years, one out of every 4-5 deaths in China died of cancer, ranking first among the causes of death. [0003] Cancer is a major problem that attracts worldw...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/52A61P35/00A61P29/00A61P37/04A61K131/00
Inventor 王伟明初东君段玉敏曹贵阳张洪娟
Owner HEILONGJIANG ZBD PHARMA
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