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Preparation method of degradable functionalmetathesis polymer nanoparticles

A nanoparticle and polymer technology, which is applied in the preparation of functional translocation polymer nanoparticles and the field of polymer nanoparticle preparation, can solve the problems that do not involve branched polymers, and achieve uniform particle size and good biological Degradation function, effect of not easy to agglomerate

Inactive Publication Date: 2013-04-10
EAST CHINA NORMAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these crosslinked polymer nanoparticles obtained so far are all in the crosslinked linear form (J. Am. Chem. Soc.2002, 124, 8653–8660; Adv. Mater.2001, 13, 204–208), comb, star (J. Am. Chem. Soc.2008, 130, 10802–10811) polymers, and these polymers are mainly obtained by free radical copolymerization, and there is no cross-linked nanoparticle preparation of branched polymers

Method used

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  • Preparation method of degradable functionalmetathesis polymer nanoparticles
  • Preparation method of degradable functionalmetathesis polymer nanoparticles
  • Preparation method of degradable functionalmetathesis polymer nanoparticles

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0021] Preparation of polymeric nanoparticles by reaction of highly branched metathesis polymers with difunctional mercapto compounds.

[0022] Under nitrogen protection, add the hyperbranched metathesis polymer (90 mg) and 1,4-butanedithiol (110 mg) (1: 2.5 molar ratio) into a 250 mL reaction flask, dissolve in 120 mL THF , a catalytic amount of dodecylamine (9 mg, 10 wt%) was added to the system, and after 6 h at room temperature, the reaction was stopped. The reaction solution was concentrated to 5 mL and then precipitated into 50 mL of methanol, the polymer was precipitated and dried in vacuum.

[0023] 1 H NMR (CDCl 3 ): δ (ppm) 6.98-6.92 (OCOCH=C H ), 6.44-6.41 (C H =CHOCO), 6.16-6.10 (CH 2 =C H OCO), 5.88-5.86 (C H =CHCOO + CH 2 =C H CH 2 O + trans -C H =C H On the polymer chain + CH=C H OCO), 5.60 ( cis -C H =C H polymer chain), 5.23-5.18 (C H 2 =CHCH 2 O + cis -C H OC H on each repeating unit), 4.70 ( trans -C H OC H on each repeating...

Embodiment 2

[0027] Highly branched metathesis polymer (90 mg), 1,4-butanedithiol (110 mg) (1: 2.5 molar ratio), the reaction time in this example is 12 h, other reaction conditions, steps and implementation Example 1 is the same. The DLS test result of the obtained polymer nanoparticles is that the average particle diameter is 106 nm, and the particle size distribution is 0.246.

Embodiment 3

[0029] Highly branched metathesis polymer (90 mg), 1,4-butanedithiol (55 mg) (1: 1.25 molar ratio), the reaction time in this example is 12 h, other reaction conditions, steps and implementation Example 1 is the same. The DLS detection result of the obtained polymer nanoparticles is that the average particle diameter is 78 nm, and the particle size distribution is 0.251.

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Abstract

The invention relates to a preparation method of degradable functional metathesis polymer nanoparticles, belonging to the technical field of nanoparticles and preparation thereof. Acrylate functional group contained in the highly-branched polymer and the multifunctional sulfhydryl compound are subjected to intramolecular crosslinking to obtain monomolecular nanoparticles with uniform dimension ofwhich the particle size is 30-120nm; the nanoparticles can be dissolved in a common organic solvent, such as dichloromethane, chloroform and tetrahydrofuran, without any surfactant; and the nanoparticles are stable, and can not easily aggregate. The metathesis polymer nanoparticles contain abundant ester bond, and thus have favorable chemical and biological degradability, and the functional groupcontent on the particle surface can be regulated by the addition of the crosslinking agent. The invention has wide application prospects in the field of biological medicine, material reinforcement, electronic devices and the like.

Description

technical field [0001] The invention belongs to the technical field of nanomaterial preparation, and relates to a preparation method of polymer nanoparticles, in particular to a preparation method of degradable functional translocation polymer nanoparticles. Background technique [0002] Polymeric nanoparticles, which are nano-sized materials, possess unique properties due to their small size, such as improved mechanical strength, tunable material properties, easily controllable transport properties, and stable size distribution, etc. It has a wide range of application prospects in medical treatment, catalysis, coatings, electronics and polymer composite materials, so it has received more and more attention. Currently, various methods can be used to synthesize polymer nanoparticles in aqueous and non-aqueous solvents, the most dominant synthesis methods being solution polymerization and dispersion polymerization. However, these two methods can only prepare polymer nanoparti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/12C08J3/24C08K5/37
Inventor 谢美然丁亮曾驰廖杨高丹怡尤泽旺
Owner EAST CHINA NORMAL UNIV