A kind of drug compound preparation containing quinolones and its preparation method and application

A technology for quinolones and compound preparations, which is applied to the field of quinolone-containing pharmaceutical compound preparations and their preparation, can solve problems such as animal refusal to eat, and achieve the effects of easy absorption, avoiding insufficient drug intake and good dispersibility

Active Publication Date: 2016-06-08
GENIFARM LAB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The object of the present invention is to provide a kind of medicine that can make animals normally use drugs according to the unpleasant feeling that the smell or taste of the drug itself brings to animals when using the existing quinolones, which will cause the animals to refuse to eat. Compound preparations containing quinolones that produce antifeedant due to odor or taste

Method used

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  • A kind of drug compound preparation containing quinolones and its preparation method and application
  • A kind of drug compound preparation containing quinolones and its preparation method and application
  • A kind of drug compound preparation containing quinolones and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Put 359 g of enrofloxacin in a 5 L three-necked flask, add it into 1000 ml of anhydrous methanol, and start stirring. In addition, 118g of succinic acid was dissolved in 600ml of anhydrous methanol, which was added dropwise to the above-mentioned flask, heated to reflux for 4 hours, sampled for inspection, and after judging the end point of the reaction, the reaction was stopped, filtered, washed with anhydrous methanol, and dried to obtain 470g enrofloxacin succinate.

Embodiment 2

[0028] Put 361g of levofloxacin in a 5L three-neck flask, add in 1200ml of absolute ethanol, and start stirring. In addition, 192g of citric acid was dissolved in 750ml of absolute ethanol, which was added dropwise to the above-mentioned flask, heated to reflux for 5 hours, and sampled for inspection. After judging the end point of the reaction, stop the reaction, filter, wash with absolute ethanol, and dry to obtain 543g Levofloxacin citrate.

Embodiment 3

[0030] The enrofloxacin succinate prepared in Example 1 and other components were mixed, pulverized and sieved according to the following formula, and the enrofloxacin powder was prepared by the usual method.

[0031] Enrofloxacin Succinate 13.3%

[0032] Sucralose 5%

[0033] Ethyl vanillin 0.5%

[0034] Sodium Chloride 30%

[0035]Add anhydrous glucose to 100% of the total amount.

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PUM

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Abstract

The invention discloses a drug compound preparation containing quinolones, a preparation method and application thereof. The drug compound preparation containing quinolones of the present invention comprises the following components by mass percentage: 0.5-95% of quinolones or their salt compounds, 1-97% of organic acids or their salt compounds, and 1-98.5% of sweeteners %, flavor enhancer 0-45%, flavoring agent 0-10%, and the balance is excipient. The finished product prepared from the drug compound preparation containing quinolones of the present invention is stable, good in dispersibility, good in palatability, easy to absorb, can be used as a broad-spectrum antibacterial agent, has strong bactericidal activity, wide distribution in the body, and no cross-resistance with other antibacterial drugs It is effective against bacteria and mycoplasma, and can be used for the treatment of various infectious diseases in the digestive system, respiratory system, urinary system or skin and soft tissues of animals caused by sensitive bacteria or mycoplasma.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a drug compound preparation containing quinolones and its preparation method and application. Background technique [0002] Quinolones (4-quinolones), also known as pyroxic acids or pyridone acids, are a relatively new class of synthetic antibacterial drugs, usually targeting bacterial DNA, hindering DNA gyrase, and further causing bacterial DNA Irreversible damage, so as to achieve antibacterial effect. There is almost no cross-resistance between these drugs, and they are ideal antibacterial drugs. [0003] There are many deficiencies in traditional quinolone drug preparations and administration methods, such as: inconvenient use, low drug bioavailability and unwillingness of users to accept, etc., which greatly limit the scope of use of quinolone drugs. have brought inconvenience. The Chinese patent application number 92110768.4 discloses a transdermal preparation ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/08A61K31/496A61K31/5383A61K31/5395A61P31/04
Inventor 王永东操基元
Owner GENIFARM LAB INC
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