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Preparation method for monodisperse cationic polystyrene microballoon sphere with controllable grain diameter

A polystyrene microsphere, cationic technology, applied in the field of preparation of monodisperse cationic polystyrene microspheres, can solve the problems of difficult control of reaction conditions, uneven particle size distribution, etc. Effect

Inactive Publication Date: 2012-04-11
HUNAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a method for preparing monodisperse cationic polystyrene microspheres with a controllable particle size using a dispersion polymerization method for the problems of difficult control of reaction conditions and uneven particle size distribution in the prior art. , using the steric hindrance stabilization mechanism and the charge stabilization mechanism at the same time, a new dispersion polymerization system was designed, which reduced the production cost and simplified the production process, and significantly improved the product performance

Method used

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  • Preparation method for monodisperse cationic polystyrene microballoon sphere with controllable grain diameter
  • Preparation method for monodisperse cationic polystyrene microballoon sphere with controllable grain diameter
  • Preparation method for monodisperse cationic polystyrene microballoon sphere with controllable grain diameter

Examples

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example 1

[0021] Commercially available styrene (analytical pure) was removed with 5wt% sodium hydroxide solution to remove the polymerization inhibitor, then washed with deionized water until neutral, dried with anhydrous calcium chloride, and then subjected to vacuum distillation for later use.

[0022] Mix 10ml of deionized water and 30ml of methanol into a 100ml three-necked flask, under the protection of nitrogen, mix 5ml of styrene, 0.25g of azobisisobutylamidine hydrochloride (V-50), and 0.5ml of hydroxyethyl acrylate Add it into a three-necked flask, mix and stir, heat, the stirring speed is 200 rpm, and react for 6 hours at a temperature of 70°C. After the reaction stopped, cool down to room temperature naturally, use a high-speed centrifuge to centrifuge, discard the supernatant, wash the precipitate with ethanol, disperse it with ultrasonic waves for 5 minutes, continue centrifuging to obtain the precipitate, and dry it in a vacuum oven at 50°C. That is, monodisperse cationic...

example 2

[0024] Commercially available styrene (analytical pure) was removed with 5wt% sodium hydroxide solution to remove the polymerization inhibitor, then washed with deionized water until neutral, dried with anhydrous calcium chloride, and then subjected to vacuum distillation for later use.

[0025] Mix 12ml of deionized water and 28ml of ethanol into a 100ml three-neck flask, under nitrogen protection, mix 7ml of styrene, 0.5g of azobisisobutylamidine hydrochloride (V-50), and 1.0ml of hydroxyethyl acrylate Add it into a three-necked flask, mix and stir, heat, the stirring speed is 200 rpm, and react for 6.5 hours at a temperature of 75°C. After the reaction stopped, cool down to room temperature naturally, use a high-speed centrifuge to centrifuge, discard the supernatant, wash the precipitate with ethanol, disperse it with ultrasonic waves for 5 minutes, continue centrifuging to obtain the precipitate, and dry it in a vacuum oven at 50°C. That is, monodisperse cationic polystyr...

example 3

[0027] Commercially available styrene (analytical pure) was removed with 5wt% sodium hydroxide solution to remove the polymerization inhibitor, then washed with deionized water until neutral, dried with anhydrous calcium chloride, and then subjected to vacuum distillation for later use.

[0028] Mix 14ml of deionized water and 26ml of methanol into a 100ml three-necked flask, under nitrogen protection, add 9ml of styrene, 0.7g of azobisisobutylamidine hydrochloride (V-50), and 2ml of hydroxyethyl acrylate Mix, stir and heat in a three-necked flask at a stirring speed of 200 rpm, and react for 7 hours at a temperature of 80°C. After the reaction stopped, cool down to room temperature naturally, use a high-speed centrifuge to centrifuge, discard the supernatant, wash the precipitate with ethanol, disperse it with ultrasonic waves for 5 minutes, continue centrifuging to obtain the precipitate, and dry it in a vacuum oven at 50°C. That is, monodisperse cationic polystyrene microsp...

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Abstract

The invention discloses a synthesis method for monodisperse cationic polystyrene microballoon sphere with controllable grain diameter. Deionized water and an organic solvent are mixed into a 100ml threeneck flask according to proportions; under the protection of nitrogen, a certain amount of styrene, initiator and polymerizable-dispersible stabilizer are together added into the threeneck flask for mixing, stirring and heating with a stirring speed of 200 RPM (Revolution Per Minute) and reacting for 6-8h when the temperature is 70-90 DEG C. After the reaction is stopped, the mixture is naturally cooled to a room temperature and is centrifuged by a supercentrifuge; a supernatant liquid is abandoned, then sediments are washed by ethanol and dispersed ultrasonically for 5 minutes; then the process is repeated for 2-3 times to obtain sediments; the sediments are dried in vacuum under 50 DEG C, so that the monodisperse cationic polystyrene microballoon sphere is obtained with a grain diameter scope between 0.4 and 1.0 Mum. The synthesis method is simple and easy. The product of the synthesis method can be used in the fields such as protein carrier, coating additive and medical diagnosis, etc.

Description

technical field [0001] The invention belongs to the field of polymer material preparation, and in particular relates to a method for preparing monodisperse cationic polystyrene microspheres with controllable particle size. Background technique [0002] Monodisperse cationic polymer microspheres not only have the characteristics of general polymer microspheres, such as: good sphericity, small size, large specific surface area, good mechanical and chemical stability, low surface tension, and easy assembly of functional groups on the surface etc., and has many unique properties. It is widely used in biomedical diagnosis, liquid chromatography analysis, catalyst carrier, coating, ink additive and other fields. Cationic polymer microsphere emulsion has an incomparable effect on anionic and non-ionic polymer microspheres in electroplating, detection of cell phagocytosis, protein carrier, adhesive, fabric treatment and printing. [0003] However, such monodisperse cationic p...

Claims

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Application Information

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IPC IPC(8): C08F212/08C08F220/28C08F4/04C08F2/12
Inventor 刘清泉李艳禄
Owner HUNAN UNIV OF SCI & TECH
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