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Silicon plastid microcapsule and preparation method thereof

A technology of microcapsules and siliceous bodies, applied in the field of biomedical materials, can solve the problems of uniform particle size, wide distribution range of siliceous body particle sizes, and affecting practical applications, and achieve good stability, uniform and controllable particle size, Solve the effect of poor stability

Inactive Publication Date: 2013-01-30
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a drug carrier, siliceous bodies have solved the various deficiencies of liposomes well, but there is a problem at the same time, that is, the particle size distribution of siliceous bodies is wide, and the particle size cannot be made uniform by conventional preparation methods. affect their future practical application

Method used

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  • Silicon plastid microcapsule and preparation method thereof
  • Silicon plastid microcapsule and preparation method thereof
  • Silicon plastid microcapsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) Prepare 0.025M Na respectively 2 CO 3 、 Ca(NO 3 ) 2 100mL each solution Ca(NO 3 ) 2 Add 400 mg polystyrene sulfonate sodium (PSS) to the solution, and after it is completely dissolved, quickly add Na 2 CO 3 Solution, stirred at 600 rpm for 15s, left to stand for 20min, centrifuged and washed three times to obtain calcium carbonate particles with a particle size of 5 microns, the laser confocal photo is shown in figure 2 .

[0035] (2) In negatively charged CaCO 3 The surface is coated with polyallylamine hydrochloride (PAH) through the principle of electrostatic layer-by-layer self-assembly to obtain CaCO 3 -PAH makes the surface positively charged and enhances the ability to combine with organic-inorganic lipids. Laser confocal photos are shown in image 3 .

[0036] (3) Precisely weigh 10 mg of organic-inorganic lipid 1, dissolve it in 2 mL of chloroform, remove the chloroform by rotary evaporation, and form a transparent lipid film at the bo...

Embodiment 2

[0038] (1) Same as Step 1 of Example 1;

[0039] (2) Same as step 2 of embodiment 1;

[0040] (3) Same as Step 3 of Example 1, except that the lipid used is organic-inorganic lipid 2 dissolved in 2 mL of dichloromethane.

Embodiment 3

[0042] (1) With step 1 of embodiment 1, the difference is that the stirring rate is 700 rpm, the time is 15s, and the diameter of the calcium carbonate particles prepared is about 3 ~ 4 microns;

[0043] (2) Same as step 2 of embodiment 1;

[0044] (3) Same as Step 3 of Example 1.

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Abstract

The invention discloses a silicon plastid microcapsule and a preparation method thereof. The preparation method for the silicon plastid microcapsule comprises the following steps: (1), dissolving organic-inorganic composite lipid in organic solvent, and removing the organic solvent by rotary evaporation to form a lipid membrane; (2), adding a template microsphere solution which is uniform in grain size to the lipid membrane for incubation; (3), carrying out a water-bath ultrasonic process to the mixed solution acquired in step (2); (4), stewing the solution at room temperature after the ultrasonic process, and forming a silicate shell layer on the surface of the template microsphere; and (5), removing the template microsphere which is coated with the organic-inorganic composite lipid on the surface to acquire the silicon plastid microcapsule. According to the invention, micron-size microsphere is used as a template and organic-inorganic lipid is used as a capsule wall material to prepare the silicon plastid microcapsule which is uniform and controllable in grain size, stable in property and dispersible. The method has a simple process, gentle operation conditions, good repeatability and can be extensively applied to such fields as packaging of active substance, a drug delivery system, embedding and catalytic reaction of enzyme, ultrasonic contrast agent, tissue engineering and the like.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a silicon body microcapsule and a preparation method thereof. Background technique [0002] Layer-by-layer self-assembly method (Layer-by-layer self-assembly, LbL) is a widely used method for preparing microcapsules. It is a self-assembly technology in which positively and negatively charged substances are alternately deposited layer by layer through electrostatic attraction. . Alternately adsorb polyelectrolytes or inorganic nanoparticles on the surface of colloidal particles to form a multilayer film. The core-shell structure particles prepared by the layer-by-layer self-assembly technology, the core can be removed by dissolving, and the capsules with nanometer or micrometer diameter cavities can be obtained. Compared with methods such as emulsion polymerization, interfacial polymerization, and phase separation coagulation, the LbL technology has the remarkable...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02
Inventor 曹众张春阳蒋庆
Owner SUN YAT SEN UNIV
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