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Preparation method of alkylphenol medicine analogue NPA

A technology of nonanoic acid phenol and alkylphenol, which is applied in the preparation of organic compounds, carboxylate salts, chemical instruments and methods, etc., can solve the problems of long detection time, expensive instruments, complicated processing, etc., and meet the requirements of immune research needs, the synthesis steps are simple, and the effect of high product purity

Inactive Publication Date: 2012-05-02
王利兵 +2
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  • Application Information

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Problems solved by technology

Although the existing instrument detection methods have the advantages of high sensitivity and wide application range, the sample pretreatment is complicated, the required instruments are expensive, the cost is high, and the detection time is long. Therefore, it is necessary to study strong specificity, high sensitivity and low price. Fast and easy immunoassay technique

Method used

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  • Preparation method of alkylphenol medicine analogue NPA
  • Preparation method of alkylphenol medicine analogue NPA
  • Preparation method of alkylphenol medicine analogue NPA

Examples

Experimental program
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Embodiment 1

[0029] The process preparation steps of nonanoic acid phenol NPA:

[0030] (1) Synthesis of compound 2:

[0031] Add compound 1 azelaic acid (353 mg, 1.875 mmol) and compound 1′ dimethyl azelate (405 mg, 1.875 mmol) into a 25 mL round bottom flask, then add 5 mL tetrahydrofuran THF, stir overnight at room temperature, after the reaction is complete , the reaction solution was concentrated to obtain the crude product which was directly used in the next reaction (0.75 g, yield: 100%).

[0032] (2) Synthesis of Compound 3:

[0033] Add methyl hydrogen azelate (0.75 g, 3.71 mmol) and thionyl chloride (1.5 mL) into a 25 mL round bottom flask, add two drops of DMF dropwise to the reaction solution, and heat the reaction solution to reflux for two hours. The reaction solution was distilled to remove thionyl chloride, and dichloromethane was used to take out residual thionyl chloride. Compound 3 was obtained (0.82 g, yield: 100%).

[0034] (3) Synthesis of Compound 4:

[0035] Ad...

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Abstract

The invention which relates to a preparation method of an alkylphenol medicine analogue NPA belongs to the technical field of the biochemical engineering. According to the preparation method, raw materials of azelaic acid and dimethyl azelate undergo a chemical reaction which comprises six steps to synthesize the alkylphenol medicine analogue NPA. The preparation method has the advantages of simple and effective synthetic step and very high purity of the obtained product, so a convenient approach is provided for the further research of people, and needs of the future immune research on alkylphenol medicines in China are satisfied.

Description

technical field [0001] The invention discloses a method for preparing nonanoic acid phenol NPA, an analogue suitable for alkylphenol drugs, and belongs to the technical field of biochemistry. Background technique [0002] Alkylphenol compounds (Alkyl Phenol, APs) are an important kind of endocrine disrupting substances, which have obvious environmental estrogen effects. Most of these compounds are fat-soluble organic compounds with strong chemical stability. Once ingested, they are not easily degraded and excreted. They are bioaccumulative and highly harmful. Even a small amount can affect organisms. At the same time, it is widely distributed in the environment and its content is low. Alkylphenol compounds APs are important fine chemical raw materials, used in surfactants, lubricating oil additives, oil-soluble phenolic resins and insulating materials, textile printing and dyeing, paper-making auxiliaries, pesticide emulsifiers, industrial detergents, anti-aging of rubber a...

Claims

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Application Information

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IPC IPC(8): C07C59/52C07C51/367
Inventor 王利兵胥传来李灼坤
Owner 王利兵
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