Method for preparing oxiracetam compound

Abstract

The invention discloses a method for preparing an oxiracetam compound, which comprises the following steps of: preparing crude products; and purifying and refining the crude products: firstly dissolving all crude products with an aqueous solution of alkyl alcohol, adding activated carbon for refluxing and discoloring, carrying out pressure filtration, stirring and crystallization on hot products for 10-30 hours, carrying out suction filtration, washing filter cake with glacial acetic acid, and carrying out vacuum drying at 40-60 DEG C to obtain a white powdery oxiracetam compound. The invention has the advantages that: the time of a reaction transition state is prolonged in an operation process, so that the reaction process is more sufficient, and the total yield is higher; the reaction process has mild conditions, so that decomposition of products and generation of byproducts are avoided; and purification adopts heating and refluxing processes, the solvent dose is small, and the purification time is short, so that decomposition of products and interfusion of other impurities are avoided and the product purity is higher. The whole preparation process is simple in operation, low in cost and easy to realize industrialized production, has good practicability, and can obtain good economic benefit and social effect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a method for preparing oxiracetam compounds. Background technique [0002] Oxiracetam was first synthesized in 1974 and launched in 1984 for improving the memory and learning functions of patients with senile dementia and memory impairment. It has been reported in the literature that the (S) and (R) single chiral configurations of oxiracetam have differences in the activity of improving brain function and the preparation method of the single isomer. So far, a large number of documents have reported various synthetic routes of oxiracetam and its enantiomers, and the adopted starting materials and reaction steps are quite different, but in summary, there are still the following problems: The yield is low; or some intermediates must be purified by column chromatography, the operation is cumbersome, and the total yield is low; or the starting material is not easy to obt...

AI Technical Summary

Problems solved by technology

It has been reported in the literature that the (S) and (R) single chiral configurations of oxiracetam have differences in the activity of improving brain function and the preparation method of the single isomer

So far, a large number of documents have reported various synthetic routes of oxiracetam and its enantiomers. The starting materials and reaction steps used are quite different, but the following problems still exist in summary: The yield is low; or some intermediates must be purified by column chromatography, the operation is cumbersome, and the total yield is low; or the starting material is not easy to obtain, and the protection and deprotection steps are increased, and the yield is reduced; in the final product of the route involving ammonolysis reaction It will be mixed with impurities, which will affect the purity; the intermediates or products in the reaction route are not easy to purify, and the total yield is low, mostly about 25%.