Process for extracting artemisinin from artemisia apiacea

A technology of artemisinin and process, which is applied in the field of artemisinin extraction process, can solve the problems of long separation and purification time, low yield, low purity, low boiling point of gasoline solvent, etc., and achieves shortened separation and purification time and high yield and purity , the effect of improving the purity

Inactive Publication Date: 2012-05-16
曾科
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] 1. The filtration and purification effect of the ultra-short and thick filter column is not ideal, the yield and purity are low and unstable;
[0008] 2. The separation and purification time is long, which affects the production efficiency;
[0009] 3. The boiling point of gasoline solvent is too low, which affects product purity and yield

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A. Dry the leaves of Artemisia annua in a cool place for 6 hours until dehydrated and then pulverize into coarse powder;

[0029] B. Put 1000g coarse powder of Artemisia annua leaves in a round bottom flask, add 2500ml of 200# gasoline and carry out reflux extraction 4 times, each time for 0.8h, after hot filtration, reclaim the solvent to 20% of the original solvent volume at 79°C;

[0030] C, filter after leaving standstill 13min, the precipitation that filters out carries out hot-melt treatment with 70% ethanol;

[0031] D. Add 2.5% activated carbon for decolorization, filter while hot, concentrate the filtrate to no alcohol smell, let stand until the crystals are precipitated to obtain coarse crystals;

[0032] E. Take the crude crystals, add an appropriate amount of 70% ethanol to dissolve them, let stand, and precipitate crystals.

[0033] F, dissolving the crystals in water, adjusting the pH value to 6.5 with triethylamine, using the treated D201 macroporous ads...

Embodiment 2

[0036] A. Dry the leaves of Artemisia annua in a cool place for 9 hours until dehydrated and then pulverize into coarse powder;

[0037] B, 1600g coarse powder of leaves of Artemisia annua is placed in a round-bottomed flask, 4800ml of 120# gasoline is added and reflux extraction is carried out 4 times, each 2h, after hot filtration, the solvent is recovered to 20% of the original solvent volume at 84°C;

[0038] C, filter after leaving standstill 26min, the precipitation that filters out carries out hot-melt treatment with 70% ethanol;

[0039] D. Add 2.5% activated carbon for decolorization, filter while hot, concentrate the filtrate to no alcohol smell, let stand until the crystals are precipitated to obtain coarse crystals;

[0040] E. Take the crude crystals, add an appropriate amount of 70% ethanol to dissolve them, let stand, and precipitate crystals.

[0041] F. Dissolve the crystals in water, adjust the pH value to 8.5 with triethylamine, use the treated D201 macropo...

Embodiment 3

[0044] A. Dry the leaves of Artemisia annua in a cool place for 11 hours until dehydrated and then pulverize into coarse powder;

[0045] B. Put 2300g coarse powder of Artemisia annua leaves in a round bottom flask, add 120# gasoline 11500ml to carry out pressurized cold cycle extraction for 3 times, each time for 4h, after hot filtration, recover the solvent at 88°C to 20% of the original solvent volume %;

[0046] C, filter after leaving standstill 15min, the precipitation that filters out carries out hot-melt treatment with 70% ethanol;

[0047] D. Add 2.5% activated carbon for decolorization, filter while hot, concentrate the filtrate to no alcohol smell, let stand until the crystals are precipitated to obtain coarse crystals;

[0048] E. Take the crude crystals, add an appropriate amount of 70% ethanol to dissolve them, let stand, and precipitate crystals.

[0049] F, dissolving the crystals in water, adjusting the pH value to 7.1 with triethylamine, using the treated D...

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PUM

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Abstract

The invention relates to a process for extracting artemisinin from artemisia apiacea. The process uses 200# gasoline as an organic solvent, and extracts by a reflux extracting method and a pressurizing cool circulating extracting method, wherein the process comprises steps like crushing, organic solvent extraction, recycling solvent, hot melting, decoloration, concentration, separating crystals and refining. In comparison with the traditional process, the process provided by the invention has advantages of lower production cost, a simpler process, a higher yield and is more suitable for modern mass production. The process shortens the separation purification time, and raises the purity, quality and stability of the product by cooperating an ion exchange resin and a macroporous absorption resin.

Description

technical field [0001] The invention relates to a process for extracting artemisinin, more specifically, the present invention relates to a process for extracting artemisinin from Artemisia annua. Background technique [0002] Artemisia annua is the dry aerial part of Artemisia annua L. Clearing away heat and relieving summer heat, removing steaming, cutting off malaria. It is used for fever caused by summer heat, fever caused by yin deficiency, night heat and morning coolness, bone steaming and labor heat, malaria cold and heat, and damp heat jaundice. It is an inexpensive antimalarial drug. [0003] Artemisinin is a sesquiterpene lactone drug with peroxy groups extracted from the traditional Chinese medicine Artemisia annua. Its effect on the ultrastructure of the red inner stage of Plasmodium murine is mainly the change of the membrane system structure of Plasmodium. Inner chromatin also has some influence. It is suggested that the mode of action of artemisinin is ma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/20
Inventor 曾科
Owner 曾科
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