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Medicinal sodium chloride production process

A production process, sodium chloride technology, applied in the field of pharmaceutical sodium chloride production process, can solve problems affecting the storage and transportation of sodium chloride, non-conforming to pharmaceutical grade, etc., achieve stable product quality and reduce production costs , the effect of high purity

Inactive Publication Date: 2012-05-30
JIANGSU QINFEN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition to a small amount of insoluble impurities, coarse salt also contains K + , Ca 2+ , Mg 2+ , Fe 3+ , SO 4 2- , CO 3 2- Soluble impurities such as corresponding salts, the existence of these impurities affects the storage and transportation of sodium chloride, and does not meet the requirements of pharmaceutical grade

Method used

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  • Medicinal sodium chloride production process
  • Medicinal sodium chloride production process
  • Medicinal sodium chloride production process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Production of medicinal sodium chloride:

[0020] 1. Saltification: Add drinking water and mother liquor to barrel A, turn on and stir, add 1200g of industrial salt, add 25g of barium chloride after dissolving, heat to boiling with steam, let it settle for 25 minutes, take a sample for detection, and the inspection shows that, Slight excess of barium salt, no sulfate. After the feed liquid is precipitated, the supernatant is taken into barrel B, 40g of sodium carbonate is added, heated to 105°C and boiled, and the sample is tested, and the pH value is 7.0, free of calcium, magnesium, and barium salts.

[0021] 2. Filtration and acid adjustment: put the qualified material liquid in barrel B into the acid adjustment tank after coarse filtration and fine filtration. After the medium feed solution is confirmed to be clear, add 3 L of hydrochloric acid to adjust the pH value to 4.5.

[0022] 3. Evaporation: pump the acid-adjusted material liquid in the acid-adjusting tank ...

Embodiment 2

[0025] The preparation method of medicinal sodium chloride provided by the invention, its quality control standard is based on "Chinese Pharmacopoeia 2010 edition (two)" and enterprise standards. The standards are as follows:

[0026] 1. Properties: This product is colorless, transparent cubic crystal or white crystalline powder; odorless and salty. This product is soluble in water, almost insoluble in ethanol.

[0027] 2. Identification: This product shows the identification reaction of sodium salt and chloride.

[0028] 3. pH: Take 5.0g of this product, add 50mL of water to dissolve it, add 2 drops of bromothymol blue indicator solution, if it turns yellow, add 0.10mL of sodium hydroxide titration solution (0.02mol / L), and it will turn blue; If it is blue or green, add hydrochloric acid titration solution (0.02mol / L), and it should turn yellow.

[0029] 4. Clarity and color of the solution: Take 5.0g of this product, add 25mL of water to dissolve, and the solution should ...

Embodiment 3

[0047] According to the production technique provided by the invention, the sodium chloride that production batch is 10.000t, according to " Chinese Pharmacopoeia 2010 edition (two) " and enterprise standard inspection, its inspection result is as follows:

[0048]

[0049]

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Abstract

The invention relates to a medicinal sodium chloride preparation method. The method includes steps that industrial salt is adopted as a raw material and is added with 0-50Kg barium chloride, supernatant is extracted after industrial salt and barium chloride mixture is heated and boiled and permitted to stand and precipitated, then 0-70Kg sodium carbonate is added, the mixture is heated and boiled, pH (potential of hydrogen) reaction is carried out within a range of 8.0 to 9.0, and then the mixture is sampled and tested to be free of sulfate and barium salt. After qualified liquid is roughly filtered, finely filtered and levigated, the pH value of the qualified liquid is regulated to a range from 3.0 to 5.0 by the aid of hydrochloride acid, and then the qualified liquid with the adjusted pH value enters an evaporator to be secondarily decompressed and evaporated. A finished product is obtained after centrifugation and drying of evaporated crystal.

Description

technical field [0001] The invention relates to a production process of sodium chloride, in particular to a production process of medicinal sodium chloride. Background technique [0002] Pharmaceutical grade sodium chloride is purified from coarse salt. In addition to a small amount of insoluble impurities, coarse salt also contains K + , Ca 2+ , Mg 2+ , Fe 3+ , SO 4 2- , CO 3 2- Soluble impurities such as corresponding salts, the existence of these impurities affects the storage and transportation of sodium chloride, and does not meet the requirements of pharmaceutical grade. [0003] The invention provides a production process of medicinal sodium chloride, and the produced sodium chloride has high purity and meets the requirements of medicinal grade. Contents of the invention [0004] The invention relates to a production process of medicinal sodium chloride, comprising the following steps: adding 0 to 50 parts by weight of barium chloride (BaCl 2 ), heated to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01D3/16
Inventor 顾小强周鸣强黄耀球
Owner JIANGSU QINFEN PHARMA
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