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Preparation method of hollow mesoporous silica nanospheres

A silica and hollow mesoporous technology, applied in the direction of silica, silica, nanotechnology, etc., to achieve the effect of mild synthesis and post-processing conditions, strong operability, and good industrial synthesis

Inactive Publication Date: 2013-08-21
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, with the deepening of research, only small molecule drug loading can no longer meet people's requirements

Method used

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  • Preparation method of hollow mesoporous silica nanospheres
  • Preparation method of hollow mesoporous silica nanospheres
  • Preparation method of hollow mesoporous silica nanospheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Add 400 mg of silica nanospheres to 45 ml of water, and obtain an aqueous dispersion of silica nanospheres after ultrasonication for 10 minutes, then reflux at 95° C. for 6 hours, and then centrifuge to collect silica nanospheres.

[0028] (2) Disperse the silica nanospheres obtained in step (1) into 10 ml of water, add 20 mg of CTAB, and stir for 3 h.

[0029] (3) Add 140 mg of NaOH to the dispersion obtained in step (2), and etch at 25° C. for 2 hours. Stand to cool, collect the precipitate, wash and dry to obtain a white powder, and remove the cationic surfactant from the white powder to obtain hollow mesoporous silica nanospheres containing larger pores.

[0030] Prepared by the embodiment of the present invention is a uniform hollow mesoporous silica nanosphere with relatively large pores (see figure 1 and 2 ). Nitrogen adsorption curves based on hollow mesoporous silica nanospheres (see image 3 ), it can be seen that mesoporous silica hollow nanospheres h...

Embodiment 2

[0032] (1) Add 400 mg of silica nanospheres to 50 ml of water, and obtain a dispersion of silica nanospheres in an aqueous phase after ultrasonication for 30 minutes, then reflux at 95° C. for 6 hours, and then centrifuge to collect silica nanospheres.

[0033] (2) Disperse the silica nanospheres obtained in step (1) into 10 ml of water, add 20 mg of CTAB, and stir for 5 h.

[0034] (3) Add 140 mg of NaOH to the dispersion obtained in step (2), and etch at 25° C. for 5.5 h. Stand to cool, collect the precipitate, wash and dry to obtain a white powder, and remove the cationic surfactant from the white powder to obtain hollow mesoporous silica nanospheres containing larger pores.

Embodiment 3

[0036] (1) Add 400 mg of silica nanospheres to 50 ml of water, and obtain a dispersion of silica nanospheres after ultrasonication for 30 minutes, then reflux at 95° C. for 12 hours, and then centrifuge to collect silica nanospheres.

[0037] (2) Disperse the silica nanospheres obtained in step (1) into 10 ml of water, add 20 mg of CTAB, and stir for 5 h.

[0038] (3) Add 160 mg of NaOH to the dispersion obtained in step (2), and etch at 15° C. for 7 hours. Stand to cool, collect the precipitate, wash and dry to obtain a white powder, and remove the cationic surfactant from the white powder to obtain hollow mesoporous silica nanospheres containing larger pores.

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Abstract

The invention discloses a preparation method of hollow mesoporous silica nanospheres and relates to a silica nanosphere. The preparation method comprises the following steps: adding the silica nanospheres into water, performing ultrasound treatment to get dispersion liquid of the silica nanospheres, then refluxing the dispersion liquid of the silica nanospheres, further centrifugating and collecting the silica nanospheres; dispersing the silica nanospheres in the water, adding cetyltrimethylammonium bromide and stirring to get the dispersion liquid; further adding NaOH, etching, standing for cooling, collecting sediment, cleaning and airing to get white powder; and removing a cationic surfactant in the white powder to get the hollow mesoporous silica nanospheres with greater aperture.

Description

technical field [0001] The invention relates to a silica nanosphere, in particular to a method for preparing a hollow mesoporous silica nanosphere. Background technique [0002] Since Beck and Kresge, the scientists of Mobil Corporation, reported for the first time in 1992 that cationic surfactants were used as templates in alkaline media, the M41s mesoporous molecular sieve series materials were synthesized in one step through hydrothermal crystallization of silicate gels (1 , C.T.Kresge, M.E.Leonowicz, W.J.Roth, J.C.Vartuli, J.S.Beck, Nature, 1992, 359, 710-712.), due to its unique structure, properties and good application prospects, mesoporous materials are widely used in basic research and practical application has received widespread attention. With the in-depth research on mesoporous materials, mesoporous nanomaterials with hollow structure have low density and high specific surface area, which are widely used in catalysis, low-density structural materials, drug carr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B33/12B82Y40/00
Inventor 郑南峰刘召辉方晓亮刘朋昕
Owner XIAMEN UNIV
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