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Preparation method of chromium methionine chelate

A technology of chromium methionine and chelate, applied in the field of preparation of chromium methionine chelate, can solve the problems of long operation time, no utility value, inability to realize continuous production, etc., and achieves short operation time, strong industrial reliability of equipment, Good crystal form and particle size

Active Publication Date: 2012-06-27
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method takes a long time to operate, and the method of adjusting the pH by dropping sodium hydroxide solution to make the product precipitate has no industrial value and cannot realize continuous production

Method used

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  • Preparation method of chromium methionine chelate
  • Preparation method of chromium methionine chelate
  • Preparation method of chromium methionine chelate

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032]4.5284g D, L-methionine (0.03mol), sodium hydroxide 1.2018g (0.03mol) and absolute ethanol were stirred and dissolved to obtain solution 1. Chromium chloride 2.6914g (0.01mol) and absolute ethanol were stirred and dissolved to obtain solution 2, and solution 1 was added thereto. Under normal pressure, 90°C, react for 0.5 hours. After the reaction is finished, cool, filter, wash, and dry to obtain a purple-red crystalline powder, and the yield of chromium methionine chelate is 86.6%.

[0033] The synthesized product was qualitatively characterized by ultraviolet and infrared spectroscopy, see figure 2 and image 3 . The content of trivalent chromium in the product is determined by ICP method, and the content of methionine is determined by pre-column derivation high performance liquid chromatography. Trivalent chromium content is 10.09%, methionine content is 89.27%

Embodiment 2

[0035] 3.0143g D, L-methionine (0.02mol), potassium hydroxide 1.122g (0.02mol) and 10% ethanol solution were stirred and dissolved to obtain solution 1. 2.6921 g (0.01 mol) of chromium chloride and 10% ethanol solution were stirred and dissolved to obtain solution 2, and solution 1 was added thereto. Under normal pressure, 30°C, react for 3 hours. After the reaction is finished, cool, filter, wash, and dry to obtain a purple crystalline powder, and the yield of chromium methionine chelate is 84.8%. Trivalent chromium content 14.82%, methionine content 85.04%

Embodiment 3

[0037] The experimental procedure is the same as above, and the reaction conditions are as follows: D, L-methionine 1.5072g (0.01mol), sodium carbonate 0.5318g (0.005mol), chromium chloride 2.6918g (0.01mol), 10% ethanol solution, under normal pressure, 90 ℃, React for 3 hours. The yield of chromium methionine chelate is 92.6%. The trivalent chromium content is 25.91%, and the methionine content is 74.02%.

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Abstract

The invention relates to a preparation method of a chromium methionine chelate. The preparation method provided by the invention comprises that main raw materials of D,L-methionine and one or more inorganic chromic salts undergo a reaction in the presence of an alcohol solution as a reaction medium at a reaction temperature of 30 to 90 DEG C for 0.5 to 3 hours to produce the chromium methionine chelate. The preparation method provided by the invention adopts the easily available raw materials, has a low production cost, allows mild reaction conditions and realizes energy saving and consumption reduction. The preparation method can be enlarged easily, is convenient for regulation and control and has good industrial application prospects.

Description

technical field [0001] The invention relates to a preparation method of a chelate, in particular to a preparation method of a chromium methionine chelate. Background technique [0002] Cr(III) is an important trace element for maintaining normal glucose metabolism and lipid metabolism in mammals, and is one of the trace elements essential for mammalian nutrition. In 1959, Schwarz and Mertz proposed the glucose tolerance factor (GTF) hypothesis (Schwarz K, Mertz W. Chromium (III) and the glucose tolerance factor [J]. Archs Biochem. Biophys. 1959, 86: 292.), and pointed out three Chromium is the active ingredient of GTF, without Cr(III), GTF is biologically inactive. Since then, a large number of studies have shown that trivalent chromium plays a very important role in the glucose metabolism and lipid metabolism of rodents, poultry such as chickens and ducks, livestock such as pigs, cattle, sheep, and mammals such as humans. Since the 1990s, trivalent chromium has become one...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C323/58C07C319/20
Inventor 肖清贵唐海燕徐红彬张懿
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI