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Oxazole organic copper compound, and preparation method and preparation thereof and purpose thereof in control of agricultural plant disease

A compound, organic copper technology, applied in the field of pesticide chemical industry, can solve the problems of sensitive plant damage, increased control cost, poor mixability, etc., and achieve the effect of easy industrial production, good cost advantage, and mild reaction conditions

Inactive Publication Date: 2012-06-27
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is characterized by an advantageous protective fungicide with low cost, but its disadvantages are: first, it is easy to cause phytotoxicity, and its use is prohibited or restricted during the flowering and young fruit stages; second, its miscibility is poor, and most of the inorganic copper preparations are Alkaline pesticides cannot be mixed with most pesticides, and it is inconvenient to use; third, it is easy to cause the value-added of mites and rust ticks, which increases the cost of control; fourth, the treatment effect is not strong, and it is not easy to use on rice
[0007] Although copper fungicides have many advantages, excessive copper ions can easily cause phytotoxicity to crops
Studies have shown that copper ions can kill pathogenic bacteria at 10mg / L, and cause phytotoxicity to sensitive plants when the concentration reaches 30mg / L
Have not yet seen the relevant report of oxazole compound copper-3-hydroxyl-5-methylisoxazole and preparation method thereof, more do not find that oxazole compound copper-3-hydroxyl-5-methylisoxazole Related reports on agricultural plant disease control

Method used

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  • Oxazole organic copper compound, and preparation method and preparation thereof and purpose thereof in control of agricultural plant disease
  • Oxazole organic copper compound, and preparation method and preparation thereof and purpose thereof in control of agricultural plant disease
  • Oxazole organic copper compound, and preparation method and preparation thereof and purpose thereof in control of agricultural plant disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Dissolve 9.6g of hydroxylamine hydrochloride (industrial product) with a purity of 98% in 100ml of pure water, stir and cool to 5°C, add 50ml of 30% by mass sodium hydroxide aqueous solution to neutralize to obtain a mixed solution, and drop the mixed solution dropwise (Each drop of 0.02~0.04ml) is added dropwise to 100ml ethyl acetoacetate, the addition is completed within 15min, then the temperature is controlled at 5℃, and the reaction is stirred for 1.5h. After the reaction is completed, add 30ml of 98% concentrated sulfuric acid The reaction was stirred at 25°C for 2h. After the reaction, it was concentrated in vacuo to obtain light yellow crystals. The light yellow crystals were heated to reflux with benzene for 2h, the solvent was evaporated, and finally recrystallized with n-hexane to obtain the compound 3-hydroxy-5-methyliso Oxazole, take 4.6g of 3-hydroxy-5-methylisoxazole and 140ml of 75% ethanol aqueous solution into a 500ml reaction flask at one time, heat an...

Embodiment 2

[0036] The preparation method of copper-3-hydroxy-5-methylisoxazole is the same as in Example 1.

[0037] Take the following weight percentages of each material: 20.0% copper-3-hydroxy-5-methylisoxazole prepared in this example, 1.0% octylphenol polyoxyethylene ether, sodium dibutyl naphthalene sulfonate The formaldehyde condensate is 4.5% and the white carbon black is 74.5%. The materials are fully mixed according to the above-mentioned ratio, and after grinding, they are passed through a 320-mesh sieve to obtain a 20% oxazole type organic copper compound wettable powder.

[0038] The tested strain was Xanthomonas oryzae pv. oryzae, provided by the Pesticide Research Institute of Northwest Agriculture and Forestry University. The prepared 20% oxazole type organic copper compound wettable powder was tested in accordance with the conventional method, and it contained 20% oxazole. The wettable powder of mycoxazole or carbendazim (the auxiliary materials and their content are the same...

Embodiment 3

[0040] Take 4.8g of commercially available hymexazol with a purity of 98% and 240ml of a methanol aqueous solution with a mass fraction of 95% and put them into a 500ml reaction flask at a time, and heat and dissolve at a temperature of 80°C to obtain solution A; the purity of 2.4g is Add 99% copper sulfate pentahydrate and 25ml distilled water to a 500ml reaction flask, heat it, and stir at 40°C to fully dissolve it. After the copper sulfate is completely dissolved in the water, add solution A under stirring. Add dropwise (0.02~0.04ml per drop) to the aqueous solution of copper sulfate, add dropwise within 25min, then control the temperature at 65°C, stir and react for 1h, after the reaction, let stand for 4h, and after fully layering, The upper layer of solution is removed, the lower layer of green precipitate is washed with absolute ethanol (or ethanol) and water in turn, and then dried in a constant temperature drying oven at 110 ℃, the green powder is copper-3-hydroxy-5-met...

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Abstract

The invention discloses an oxazole organic copper compound, and a preparation method and a preparation thereof and purpose thereof in control of agricultural plant diseases. The method comprises steps of: carrying out aqueous phase process on hydroxylamine hydrochloride and ethyl acetoacetate too generate 3-hydroxy-5-methyl isoxazole; adding the compound and cupric salt into an organic solvent for reaction; successively carrying out separation, washing and drying after the reaction. The preparation method of the invention is simple, practical, low-cost and pollution-free; and the prepared novel oxazole compound copper-3-hydroxy-5-methyl isoxazole has stable property and wide sterilization spectrum, can be used in controlling agricultural plant diseases, especially in controlling diseases canused by Fusarium sp, Aphanomyces invadans, pythium and corticium, and has special effects on various soil borne diseases and seedling blight.

Description

Technical field [0001] The invention belongs to the technical field of pesticide chemical industry, and particularly relates to an oxazole organic copper compound, a preparation method, a preparation, and use in the prevention and control of agricultural plant diseases. Background technique [0002] The molecular formula of 3-hydroxy-5-methylisoxazole (oxamelin) is C 4 H 5 NO 2 , Molecular weight is 99, soluble in most organic solvents, stable in acid and alkali solutions, non-corrosive, is a systemic fungicide and plant growth regulator. With systemic and conductive properties, it can be directly absorbed by plant roots, enter the plant body, and move extremely quickly. It moves to the stem after only 3 hours in the root system, and moves to the whole body of the plant within 24 hours. Its metabolites in the plant body are two glucosides, which can promote plant growth and root development. In addition, 3-hydroxy-5-methylisoxazole has the characteristics of high efficiency, low...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D261/12A01N43/80A01P1/00A01P3/00
Inventor 王永华张慧晓刘蒙蒙周伟王高学段金友
Owner NORTHWEST A & F UNIV
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