Chinese medicinal health-care white spirit with health maintenance effect and preparation method thereof
A technology of traditional Chinese medicine health care and health care wine, which is applied in the preparation of alcoholic beverages, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of not very obvious effect, low content, uneven levels, etc. The taste is round and soft, the source is rich, and the effect of drinking is convenient
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experiment example 1
[0029] Experimental Example 1: 60 SD rats were randomly divided into 6 groups, which were respectively blank control group, model control group, positive control group (digoxin), and medicinal wine ratio 1 group (longan: Polygonatum: Lycium barbarum = 1: 1:1), ratio 2 groups (longan: Polygonatum: wolfberry = 1: 1.5: 2), ratio 3 groups (longan: polygonatum: wolfberry = 2: 1: 1.5). Except for the blank control group, the animals in the other groups were manufactured chronic heart failure models according to the literature method, and the doses of 20, 10, and 5 mg / kg per day were gradually reduced for the first 3 days, and administered subcutaneously, and then subcutaneously injected with a dose of 3 mg / kg for 10 days. days, a total of 13 days for modeling. At the same time as the model was being established, each proportioning group of medicinal wine was administered 2ml once a day for 13 consecutive days; the positive group was administered digoxin at a dose of 0.27 mg / kg once ...
experiment example 2
[0035] Experimental example 2: 60 SD rats were randomly divided into 6 groups, namely blank control group, model control group, positive control group (benazepril), drug-wine ratio 1 group, ratio 2 group, ratio 3 Group. Except for the normal control group, 0.2% doxorubicin solution 7 mg / kg was injected through the tail vein once. The normal group was injected with the same dose of normal saline. After confirming that the modeling was successful in the 4th week, each medicated wine formula group was administered with 2ml respectively, the normal group and the model group were given the same amount of normal saline every day, and the positive drug group was given 0.25% benazepril 10mg / kg every day, continuously. medicine for 12 weeks.
[0036] At the 4th week of modeling, the 8th week and the 12th week after administration, 24-hour urine volume was collected, and blood was collected through the retro-orbital vein to measure changes in urine protein content and renal function i...
experiment example 3
[0047]Experimental example 3: Kunming mice, 50, were randomly divided into 5 groups, 10 in each group, including blank control group, positive control group, medicinal wine ratio 1 group, ratio 2 group, ratio 3 group, medicinal liquor group Gavage each rat with 0.2ml per day, and the blank group with the same volume of normal saline, for 4 consecutive days. At the last dose, the positive drug group was given atropine 20mg / kg, and 0.2ml of each rat was given 0.1% methyl orange 2.5 hours later. After gavage with the solution, the animal was sacrificed by dislodging the cervical spine after 20 minutes. The whole stomach was removed, put into a small beaker, and 10ml of distilled water was added. 6.0-6.5, centrifuge for 10 minutes, take the supernatant and measure the absorbance by colorimetry, take the absorbance of 0.1% methyl orange solution 0.2ml and add 10.0ml distilled water as the base number of methyl orange, and calculate the emptying rate.
[0048] The results showed tha...
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