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Stable moxifloxacin hydrochloride medicinal composition

A technology of moxifloxacin hydrochloride and its composition, which is applied in the field of pharmaceuticals in the field of medicine, can solve the problems of SFDA unapproved production by domestic manufacturers, achieve the effects of no allergic reaction, simple and easy method, and reduce the toxic and side effects of drugs

Inactive Publication Date: 2012-07-04
TIANJIN HANKANG PHARMA BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, SFDA has not approved domestic manufacturers to produce

Method used

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  • Stable moxifloxacin hydrochloride medicinal composition

Examples

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Effect test

Embodiment 1

[0090] The described moxifloxacin hydrochloride pharmaceutical composition of every 1000, its formula consists of:

[0091] Moxifloxacin hydrochloride calculated as moxifloxacin 400g

[0092] Hydroxypropyl Beta Cyclodextrin 100g

[0093] 80% ethanol solution 5L

[0094] Mannitol 70g

[0095] Microcrystalline Cellulose 12 30g

[0096] Magnesium Stearate 10g

[0097] Preparation Process:

[0098] 1) Moxifloxacin hydrochloride spray-dried powder preparation: Dissolve the prescribed amount of hydroxypropyl beta cyclodextrin in 80% ethanol solution and stir to dissolve, then add the prescribed amount of moxifloxacin hydrochloride and stir to dissolve completely, then spray dry Obtain uniform particles with a particle size of 80±10 μm, and set aside;

[0099] 2) Mix item 1) with the prescribed amount of mannitol, microcrystalline cellulose 12, and magnesium stearate;

[0100] 3) Tablet compression: adjust the appropriate hardness and tablet weight to perform tablet compression;...

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Abstract

The invention discloses a stable moxifloxacin hydrochloride medicinal composition and a preparation method thereof. The stable moxifloxacin hydrochloride medicinal composition consists of moxifloxacin hydrochloride, hydroxypropyl betacyclodextrin, mannitol, microcrystalline cellulose 12 and magnesium stearate. The stable moxifloxacin hydrochloride medicinal composition is high in stability, has the obvious advantages of improving the yield of products, reducing cost and implementing industrialization and is better applied clinically, and preparations of the stable moxifloxacin hydrochloride medicinal composition have high stability.

Description

technical field [0001] The invention relates to medicines in the medical field, in particular to a moxifloxacin hydrochloride pharmaceutical composition with good stability and a preparation method thereof. Background technique [0002] With the widespread use and even abuse of antibacterial agents, bacterial drug resistance is increasing year by year. Drug-resistant bacterial infections not only seriously endanger human health, but also become a thorny problem worldwide. It is reported that about 2 million nosocomial infections occur annually among hospitalized patients in the United States, and about 90,000 of them die. More than 70% of hospital-acquired infections have developed resistance to commonly used antibacterial drugs in clinical practice. Therefore, accelerating research and development can effectively deal with severe infections and drug resistance caused by Gram-positive bacteria, especially methicillin-resistant Staphylococcus aureus (MRSA). Oral antibacteria...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4709A61K47/40A61P31/04
Inventor 严洁黄欣
Owner TIANJIN HANKANG PHARMA BIOTECH
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