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Plant officinal hollow capsule and preparation method thereof

A hollow capsule and medicinal technology, which is applied in the directions of capsule delivery, pharmaceutical formulations, and medical preparations with inactive ingredients, etc., can solve the problems of fragility of starch film, slow disintegration speed, and poor starch film-forming property, etc. Market prospect and practical value, the effect of improving disintegration performance and low price

Inactive Publication Date: 2013-10-30
HUBEI HUMANWELL PHARMACEUTICAL EXCIPIENTS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In recent years, plant hollow capsules and microbial polysaccharide hollow capsules have appeared. For example, modified starch is used as a capsule raw material, which cannot be regarded as a natural plant capsule raw material due to chemical modification; starch film-forming properties are poor, and the starch film is easily broken. It is difficult to meet the requirements of friability when making capsules with mild starch; the quality of hollow capsules made of microbial polysaccharides such as pullulan is better, but the disintegration speed is slow, and the market has not yet been opened due to the high price of raw materials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] First prepare the partial enzymatic hydrolyzate of kudzu powder, weigh 160 grams of kudzu powder, put it in a 1000 ml conical flask, add 800 g of deionized water in batches, stir while adding water, adjust the pH to 5.5 with hydrochloric acid, raise the temperature to 95 °C, and keep it warm for 10 Minutes, the inside of the triangular flask is a uniform viscous paste, transfer the triangular flask to a portable sterilizer, and heat it at 121°C for 30 minutes to completely gelatinize.

[0029] The gelatinized kudzu root powder is cooled to 60°C, and isoamylase is added with an enzyme dosage of 8000 enzyme units. The enzymolysis reaction is incubated at 60°C in a water bath for 180 minutes, and immediately transferred to boiling water for 20 minutes to terminate the enzyme reaction.

[0030] The above reaction solution was centrifuged at 8000rpm on a TG16-WS desktop centrifuge for 17 minutes, the lower part of the precipitate was removed, and the upper part of the centrif...

Embodiment 2

[0034]Add 5 grams of pullulan and 0.5 grams of glycerol to 100 ml of the upper part of the kudzu powder enzymolysis solution made in Example 1 (containing about 20 grams of solid matter); add 0.3 gram of gellan gum in another beaker, add 50 ml to remove Boil deionized water until completely dissolved, then add 0.18 grams of potassium chloride, mix with arrowroot enzymatic hydrolyzate and pullulan immediately while hot, then add 0.025 grams of sodium dodecylsulfonate, all the above mixtures are emulsified and sheared with FA25 Machine 8000 revolutions per minute and mix evenly, keep warm in a 200ml beaker above 70°C for 4 hours to debubble, cool down the mixture after degassing to 53°C-58°C, dip the hollow capsule manual mold with glue , the mold dipped in glue is placed in an electric oven at 30°C to 40°C to air dry, the wall thickness of the capsule after demolding is 0.08mm to 0.12mm, and the hollow capsule inspection: good and standard size, high transparency, excellent diss...

Embodiment 3

[0036] Add 10 grams of carboxymethyl cellulose and 0.6 grams of glycerol to 100 ml of the upper centrifugation liquid (containing about 20 grams of solids) of the arrowroot partial enzymolysis solution made in Example 1; add 0.35 grams of gellan gum in another beaker, add 70 ml Boil deionized water until completely dissolved, then add 0.20 grams of potassium chloride, immediately mix with arrowroot hydrolyzate and carboxymethyl cellulose while hot, then add 0.03 grams of sodium dodecylsulfonate, all the above mixtures are emulsified with FA25 The shearing machine rotates at 8000 rpm and mixes evenly. In a 200ml beaker, keep warm at 70°C for 4 hours. After degassing, the mixture cools down to 53°C-58°C. Dip the hollow capsule into a manual mold, and place the mold dipped in the electric heater. Air-dry in an oven at 30°C to 40°C, and the wall thickness of the capsule after demoulding is 0.08mm to 0.12mm. Empty capsule testing: as the preheating temperature for pin insertion, 60°...

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PUM

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Abstract

A plant officinal hollow capsule comprises following components by weight percentage composition: 50% to 70% of arrowroot part zymolyte, 20% to 45% of a reinforcing agent, 0% to 6% of gelata, 0% to 10% of a plasticizing agent, 0% to 1% of a coagulant agent, 0% to 1% of a dispersing agent, 0% to 0.1% of food colorant and the balance water. The preparation method comprises the steps of (1) mixing the arrowroot part zymolyte with the reinforcing agent, the plasticizing agent and the food colorant; (2) adding the gelata into deionized water, boiling until the gelata completely melts, and adding the coagulant agent; (3) mixing two parts of the step (1) and the step (2) when the two parts are hot, adding the dispersing agent, stirring evenly, standing and removing air bubbles to achieve mixed liquid; (4) preparing the capsule through a capsule mold in a mold dipping method; and (5) demolding to obtain the plant officinal hollow capsule. The capsule can meet index standards of officinal capsules, can be used for accommodating powder, oil-shaped liquid, semisolid and paste, cannot be soft and deform in summer due to high temperature or be fragile in winter due to coldness and dry.

Description

technical field [0001] The invention relates to a medicinal plant hollow capsule and a preparation method thereof, in particular to a plant hollow capsule produced by coordinating a partial enzymatic hydrolyzate of kudzu root powder as a raw material, a reinforcing agent, a gelling agent, etc., and a preparation method thereof. technical background [0002] At present, the medicinal hollow capsules on the market are mainly produced from gelatin. Gelatin capsules are widely used in medicine and health care products. However, such hollow capsules derived from animals are not accepted in Islamic countries and some minority areas in my country. Influenced by zoonotic diseases, animal protein also has potential safety hazards to a certain extent, and gelatin capsules also have some defects. In summer or at higher temperatures, the shell of gelatin capsules is easy to soften and deform, which affects transportation and use. The shell is brittle, and certain ingredients in the drug m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/46
Inventor 黄建华黄文华黄耀华
Owner HUBEI HUMANWELL PHARMACEUTICAL EXCIPIENTS CO LTD
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