Synthesis method for carisoprodol

A synthetic method and the technology of carisoprodol, applied in the field of compound preparation, can solve problems such as difficult control, harsh reaction conditions, and expensive raw material cyanate, and achieve easy separation, stable route yield, and mild reaction conditions Effect
CN102531965AInactive Publication Date: 2012-07-04YIYUAN XINQUAN CHEM
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
YIYUAN XINQUAN CHEM
Publication Date
2012-07-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to a preparation method for a compound, and specifically to a synthesis method for carisoprodol. The method is characterized in that the synthesized 5-methyl-5-propyl-1,3-dioxane-2-one is adopted as a raw material; the 5-methyl-5-propyl-1,3-dioxane-2-one and isopropamide are subjected to an aminolysis reaction to generate 2-methyl-2-propyl-3-hydroxypropyl-N-isopropyl carbamate; the 2-methyl-2-propyl-3-hydroxypropyl-N-isopropyl carbamate and urea are subjected to a condensation reaction under a catalysis effect of a metal oxide to synthesize the carisoprodol. The method of the present invention has the following advantages that: a new method for synthesis of the carisoprodol from the 2-methyl-2-propyl-3-hydroxypropyl-N-isopropyl carbamate is provided; the cheap and easily-obtained urea is adopted as the raw material by the method; the yield is stable, and the reaction conditions are mild; the raw material cost is reduced in the synthesis process, and the generated ammonia is easily separated so as to simplify the production process.
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Description

technical field

[0001] The invention relates to a preparation method of a compound, in particular to a synthesis method of carisoprodol. Background technique

[0002] Carisoprodol is a derivative of meprobamate, which is a typical representative of carbamate psychotropic drugs. It is mainly used for the treatment of acute muscle spasm and skeletal muscle pain. It has good curative effect on local muscle spasm and some neurological diseases. Non-addictive, with little toxic and side effects, it has been widely used in clinical medicine and has been well received by doctors and patients.

[0003] This drug has been included in the pharmacopoeia of many countries and has a very large demand for use.

[0004] At present, there are three processes for the synthesis of 5-methyl-5-propyl-1,3-dioxane-2-one, an important intermediate of carisoprodol:

[0005] (1) Phosgene route

[0006] It is the reaction of 2-methyl-2-propyl-1,3-propanediol with phosgene, and the resulting produc...

Claims

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