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Accurate measurement fed-batch device for fermentation tank and fed-batch method for high-concentration solution

A fermenter and feed-feeding technology, which is applied in the field of precise metering feed-feeding devices for fermenters and high-concentration solution feed-feeding fields, to achieve the effects of fewer interference factors, lower production costs, and long service life

Inactive Publication Date: 2012-07-04
TIANJIN INST OF IND BIOTECH CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Aiming at the defects of the existing metering feeding feeding device and method, the present invention provides a device and method for accurately controlling the volume and flow velocity of feeding high-concentration feeding liquid during the fermentation process

Method used

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  • Accurate measurement fed-batch device for fermentation tank and fed-batch method for high-concentration solution
  • Accurate measurement fed-batch device for fermentation tank and fed-batch method for high-concentration solution
  • Accurate measurement fed-batch device for fermentation tank and fed-batch method for high-concentration solution

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Effect test

Embodiment 1

[0035] Accurate metering feeding device for fermenter. Fermentation tank 1 is sequentially connected with feeding pipe valve 8, filter rear valve 7, membrane filter 2, metering pump outlet valve 5, metering pump 3, metering pump inlet valve 11 and feeding tank 4 through pipelines; steam exhaust Valve 6 is connected to the fermenter 1 side of metering pump outlet valve 5 by pipeline, exhaust valve 10 is connected to the fermenter 1 side of feeding pipe valve 8 through pipeline; one end of steam valve 9 is connected to The other end of the steam valve 9 is connected to the steam pipeline S on the side of the valve 7 after the filter of the feeding pipe valve 8 .

[0036] The electronic monitoring system is composed of a process parameter sensor, an instruction input system, an electronic control device, a feed rate controller, a display module, a recorder and a monitoring system connected through a signal line of a communication network. The command input system inputs commands...

Embodiment 2

[0038] 50m 3 Non-feedback feeding sugar supplementation and feedback feeding defoaming for tank citric acid fermentation:

[0039] Two sets of precise metering feed feeding devices, one feed feeding device feeds glucose syrup, which is the glucose syrup feed device; the other feed defoamer feed device, which is the defoamer feed device.

[0040] The membrane filter 2 of the glucose syrup feeding device has a membrane pore size of 0.2 μm, stores the glucose syrup with a solid content of 76% in the feeding tank, and keeps the metering pump inlet valve 11 open. When the fermentation tank is actually sterilized, close the metering pump outlet valve 5 and the feed pipe valve 8, open the exhaust valve 10, and sterilize the pipeline between the flow feed valve 8 and the fermenter 1. Open filter back valve 7, steam exhaust valve 6 and steam valve 9, feed steam from steam pipe S, and sterilize the pipeline between the membrane filter 2 and the valve 8 of the feeding pipe. After the s...

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Abstract

The invention relates to an accurate measurement fed-batch device for a fermentation tank and a fed-batch method for a high-concentration solution. The fed-batch device comprises the fermentation tank, a membrane filter, a measuring pump, a fed-batch tank, valves and an electronic monitoring system. A fed-batch tube valve, a filter rear valve, the membrane filter, a measuring pump liquid outlet valve, the measuring pump, a measuring pump liquid inlet valve and the fed-batch tank are connected in sequence through a pipeline from the fermentation tank; an exhaust steam valve is connected onto one side of the fermentation tank of the measuring pump liquid outlet valve by a pipeline; one end of a steam valve is connected onto one side of the filter rear valve of the fed-batch tube valve through a pipeline; the other end of the steam valve is connected with a steam pipeline S; and another exhaust steam valve is connected onto one side of the fermentation tank of the fed-batch tube valve through a pipeline. A fed-batch material is a low-water activity high-concentration solution, and bacteria in fed-batch liquid are removed by filtration by a membrane filtration method without steam sterilization. According to indicative indexes in the fermentation process, such as fermentation time, pH, foam height and fermentation respiratory quotient, accurate measurement fed-batch feed supplement is performed through the electronic monitoring system. The control precision of feed supplement amount reaches 1 percent or less. The accurate measurement fed-batch device is suitable for different-scale fermentation tanks for experiments and production.

Description

technical field [0001] The invention relates to a precise metering feeding device for a fermenter and a method for feeding a high-concentration solution, in particular to a device and a method for accurately controlling the volume and flow velocity of a high-concentration feeding solution during the fermentation process. Background technique [0002] In the fermentation process, a certain nutrient is often used as a restrictive substrate, and the nutrient flow-feeding technology is a commonly used fermentation control strategy. The fed-batch feeding operation is often the key operation for the optimization and regulation of the biological reaction process. Therefore, the fed-batch feeding device It has become a must-have device for most bioreactors. The materials fed during the fermentation process include acids, alkalis, neutralizers, defoamers, carbon sources, nitrogen sources, enzyme preparations, precursors, and inducers. requirements are getting higher and higher. [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/36C12M1/12C12Q3/00
CPCC12M29/20C12M41/26C12M41/02
Inventor 田一梅张笑然
Owner TIANJIN INST OF IND BIOTECH CHINESE ACADEMY OF SCI
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