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Cefcapene pivoxil hydrochloride hydrate composition tablets

A technology of cefcapine and a composition, which is applied in the field of medicine, can solve the problems of affecting drug efficacy, tablet hardness and tablet drug efficacy being difficult to satisfy at the same time, affecting tablet absorption and the like

Active Publication Date: 2015-03-11
SHANDONG LUOXIN PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, clinical treatment mostly adopts the form of cefcarpine pivoxil hydrochloride tablet, but the hardness of the tablet and the drug effect of the tablet are not easy to satisfy at the same time.
Tablets with better hardness are less likely to disintegrate, affecting the absorption of the tablet in the animal body, thereby affecting the efficacy of the drug; tablets with lower hardness are easy to disintegrate and absorb in the animal body, and the drug effect is easily exerted. However, the tablet is easily damaged during the process of preparation, transportation and storage.

Method used

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  • Cefcapene pivoxil hydrochloride hydrate composition tablets
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  • Cefcapene pivoxil hydrochloride hydrate composition tablets

Examples

Experimental program
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Effect test

Embodiment 1

[0035] Embodiment 1 The cefcarpine pivoxil hydrochloride composition tablet provided by the present invention

[0036] Accurately weigh 100 mg of cefcarpine pivoxil hydrochloride, 30 mg of microcrystalline cellulose, 22 mg of mannitol, 22 mg of hyprolose, 1.5 mg of magnesium stearate, and 0.5 mg of lactose;

[0037] Described microcrystalline cellulose, mannitol, lactose are pulverized respectively and crossed 80 mesh sieves, respectively crossed 100 mesh sieves by cefcapine hydrochloride pivoxil, hydroxypropyl cellulose, magnesium stearate; Ester, 30mg of microcrystalline cellulose, 22mg of mannitol and 11mg of hydroxypropyl cellulose were mixed and crushed and sieved to collect 24 mesh particles, and 11mg of hydroxypropyl cellulose and 1.5mg of magnesium stearate were added, and after mixing, The cefcarpine pivoxil hydrochloride tablet was obtained after tabletting; the Opadry coating powder of 4.4 mg was made into a 4% coating with a mass fraction of 80% ethanol of 55 mg. ...

Embodiment 2

[0038] Embodiment 2 The cefcarpine pivoxil hydrochloride composition tablet provided by the present invention

[0039] Accurately weigh 100 mg of cefcarpine pivoxil hydrochloride, 30 mg of microcrystalline cellulose, 22 mg of mannitol, 22 mg of hyprolose, 1.5 mg of magnesium stearate, and 0.5 mg of lactose;

[0040] Described microcrystalline cellulose, mannitol, lactose are pulverized respectively and crossed 80 mesh sieves, respectively crossed 100 mesh sieves by cefcapine hydrochloride pivoxil, hydroxypropyl cellulose, magnesium stearate; Ester, 30mg of microcrystalline cellulose, 22mg of mannitol and 11mg of hydroxypropyl cellulose were mixed and crushed and sieved to collect 24 mesh particles, and 11mg of hydroxypropyl cellulose and 1.5mg of magnesium stearate were added, and after mixing, Acid cefcarpine pivoxil composition is obtained, cefcarpine pivoxil hydrochloride tablet is obtained after tabletting; the Opadry coating powder of 4.4mg is made the mass fraction of 6%...

Embodiment 3

[0041] Embodiment 3 Cefcarpine pivoxil hydrochloride composition tablet provided by the present invention

[0042] Accurately weigh 100 mg of cefcarpine pivoxil hydrochloride, 30 mg of microcrystalline cellulose, 22 mg of mannitol, 22 mg of hyprolose, 1.5 mg of magnesium stearate, and 0.5 mg of lactose;

[0043] Described microcrystalline cellulose, mannitol, lactose are pulverized respectively and crossed 80 mesh sieves, respectively crossed 100 mesh sieves by cefcapine hydrochloride pivoxil, hydroxypropyl cellulose, magnesium stearate; Ester, 30mg of microcrystalline cellulose, 22mg of mannitol and 11mg of hydroxypropyl cellulose were mixed and crushed and sieved to collect 24 mesh particles, and 11mg of hydroxypropyl cellulose and 1.5mg of magnesium stearate were added, and after mixing, Obtained acid cefcarpine pivoxil composition, made cefcarpine pivoxil hydrochloride tablet after tabletting; The Opadry coating powder of 4.4mg is made the coating that mass fraction is 8% ...

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Abstract

The invention relates to the technical field of medicines, in particular to cefcapene pivoxil hydrochloride hydrate composition tablets. The cefcapene pivoxil hydrochloride hydrate composition tablets comprise the following components in part by weight: 100 parts of cefcapene pivoxil hydrochloride hydrate, 30 parts of microcrystalline cellulose, 22 parts of mannitol, 22 parts of hydroxyl cellulose, 1.5 parts of magnesium stearate and 0.5 to 1 part of lactose. Compared with a positive medicinal control group, the cefcapene pivoxil hydrochloride hydrate composition tablets have the advantage that a medicinal effect is improved obviously.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a composition tablet of cefcarpine pivoxil hydrochloride. Background technique [0002] Japan Shionogi Pharmaceutical Co., Ltd. chemically modified the 7-position and 3-side chains of the cephalosporin nucleus, and obtained a broad-spectrum antibacterial compound cefcapine that is effective on both Gram-positive bacteria and Gram-negative bacteria after screening , Cefcapine has strong antibacterial activity against Gram-positive bacteria such as Staphylococcus aureus and Streptococcus and Gram-negative bacteria. But cefcapine is not easy to be absorbed orally, and it is subjected to esterification treatment to obtain a compound that is well absorbed orally, namely cefcapene pivoxil hydrochloride. Cefcapene Pivoxil Hydrochloride Hydrochloride is the pivaloyloxymethyl ester of Cefcapene, a third-generation oral cephalosporin drug. After cefcarpine pivoxil hydrochloride is absor...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K9/36A61K31/546A61K47/26A61K47/38A61P31/04
Inventor 宋良伟冯长运曹传
Owner SHANDONG LUOXIN PHARMA GRP CO LTD
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