Musk Baoxin long-acting medicine product and preparation method thereof

A musk heart-protecting and drug product technology, which is applied in the direction of medical formula, drug combination, drug delivery, etc., can solve the problems of volume and ratio changes, pharmacological effects and curative effect reduction, etc., achieve small dosage, reduce myocardial infarction area, improve left The effect of chamber remodeling

Inactive Publication Date: 2012-07-11
HEHUANG PHARMA SHANGHAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main problem of this method is that it changes the release and absorption site of the drug in the gastrointestinal tract, which leads to changes in the amount and ratio of each component absorbed into the body, that is, indirectly changes the composition of the original prescription and changes the composition of the original prescription. It turns out that the ratio of each medicine flavor to the monarch, minister and assistant envoy
The consequence of this is that although the sustained release of the ingredients is achieved, the pharmacological effects and even curative effects may be reduced

Method used

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  • Musk Baoxin long-acting medicine product and preparation method thereof
  • Musk Baoxin long-acting medicine product and preparation method thereof
  • Musk Baoxin long-acting medicine product and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Preparation of immediate-release tablets: 20% bulk drug (provided by Shanghai Hutchison Pharmaceutical Co., Ltd.) with 10% disintegrating agent crospovidone, 10% disintegrating agent sodium carboxymethyl starch, 59% filler microcrystalline cellulose Su and 1% lubricant micro-powder silica gel are mixed in proportion, and the powder is directly compressed into tablets to obtain the product. Each tablet weighs about 78mg. Dissolution test results showed that ginsenoside Rb 1 , cinnamic acid and borneol 45min cumulative dissolution percentage> 80%.

[0042] Preparation of pulse-release tablets:

[0043] ① Tablet core: mix 60% raw material drug (provided by Shanghai Hutchison Pharmaceutical Co., Ltd.) with 20% disintegrant crospovidone, and 20% filler microcrystalline cellulose, and use a 4mm die to compress the powder directly. That is to get the tablet core, each tablet weighs about 26mg. Dissolution test results showed that ginsenoside Rb 1 , cinnamic acid and borne...

Embodiment 2

[0048] The preparation of immediate-release tablet: 20% crude drug (provided by Shanghai Hehuang Pharmaceutical Co., Ltd.) is mixed with 7% disintegrant crospovidone, 72% filler microcrystalline cellulose, 1% lubricant micropowder silica gel in proportion Evenly, the powder is directly compressed into tablets. Each tablet weighs about 78mg. Dissolution test results showed that ginsenoside Rb 1 , cinnamic acid and borneol 45min cumulative dissolution percentage> 80%.

[0049] Preparation of pulse-release tablets:

[0050] ① Tablet core: Mix 60% raw material drug (provided by Shanghai Hutchison Pharmaceutical Co., Ltd.) with 5% disintegrating agent crospovidone and 35% filler lactose, and use a 4mm die to compress the powder directly to obtain tablets Core, each tablet weighs about 26mg.

[0051] ②Short-time-delay pulse-release tablet: the coating material 39mg HPMC E15 (accounting for 60% of the pulse-release layer) by the second compression method, floating layer material:...

Embodiment 3

[0055] The preparation of immediate-release tablet: 20% bulk drug (provided by Shanghai Hehuang Pharmaceutical Co., Ltd.) and 3% disintegrant sodium carboxymethyl cellulose, 76% filler compressible starch, 1% lubricant micropowder silica gel in proportion Mix well, and the powder is directly compressed into tablets to obtain the product. Each tablet weighs about 78mg. Dissolution test results showed that ginsenoside Rb 1 , cinnamic acid and borneol 45min cumulative dissolution percentage> 75%.

[0056] Preparation of pulse-release tablets:

[0057] ① Tablet core: mix 60% raw material medicine (provided by Shanghai Hutchison Pharmaceutical Co., Ltd.) with 10% disintegrant sodium carboxymethyl starch and 30% compressible starch, use a 4mm die, and directly compress the powder into tablets to obtain Tablet core, each tablet weighs about 26mg.

[0058] ②Short-time-delay pulse-release tablet: use the second compression method to coat material 105mg HPMC E15 (80% of the pulse-re...

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Abstract

The invention provides a musk Baoxin long-acting medicine product, which comprises a musk Baoxin quick-release tablet and a gastric floating type musk Baoxin pulse release tablet. According to the musk Baoxin long-acting medicine product disclosed by the invention, the quick-acting characteristic of the original preparation is kept while the medicine taking times is reduced. More importantly, the internal behavior of the original preparation is not changed. The musk Baoxin long-acting medicine product has a positive meaning for enriching the dose type of the musk Baoxin preparation and satisfying the clinic requirement application.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a long-acting musk-protecting heart-protecting medicinal product and a preparation method thereof. Background technique [0002] Shexiang Baoxin Pill has the functions of warming aroma, nourishing qi and strengthening the heart, etc. It is mainly used for chest obstruction caused by qi stagnation and blood stasis, angina pectoris and myocardial infarction caused by myocardial ischemia. It is the most commonly used clinical cardiovascular disease One of Chinese patent medicines for treatment and prevention. In recent years, the research on Shexiang Baoxin Pills has continued to deepen. Through the combination of chemical and pharmacological research methods, the material basis of its medicinal effects and the scientific rationality of its compatible prescriptions have been gradually revealed. More and more clinical applications have proved that i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/54A61K9/22A61K47/32A61K47/38A61P9/10A61K31/045A61K35/413A61K35/55A61K35/56A61K35/65
Inventor 王建新韩丽妹何红伟丁建弥詹常森陈忠梁
Owner HEHUANG PHARMA SHANGHAI
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