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Application of sinomenine in preparation process of drugs inhibiting invasion and metastasis of tumors

A technology for sinomenine and tumors, which is applied in the application field of sinomenine in the preparation of drugs for inhibiting tumor invasion and metastasis, and can solve the problems that there are no relevant reports on the inhibition of tumor invasion and metastasis by sinomenine, and achieve wide medicinal value, Effects with low toxicity and few side effects

Inactive Publication Date: 2012-07-18
张有成 +1
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Problems solved by technology

In recent years, there are also literature reports on the effects of sinomenine on other autoimmune diseases, anti-transplant rejection and anti-tumor, but more research reports focus on the anti-tumor effect of sinomenine by inhibiting tumor Apoptosis plays a role, but there is no relevant report on sinomenine inhibiting tumor invasion and metastasis

Method used

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  • Application of sinomenine in preparation process of drugs inhibiting invasion and metastasis of tumors
  • Application of sinomenine in preparation process of drugs inhibiting invasion and metastasis of tumors
  • Application of sinomenine in preparation process of drugs inhibiting invasion and metastasis of tumors

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Embodiment 1

[0033] Human liver cancer cell line MHCC97H, human pancreatic cancer cell line PANC-1, human colon cancer cell line HT-29 and human gastric adenocarcinoma cell line HGC-27 all confirmed the inhibitory effect of sinomenine on tumor invasion and metastasis by the following methods:

[0034] 1. MTT method to detect cell proliferation:

[0035] Digest the four kinds of digestive system tumor cells in the logarithmic growth phase with 0.25% trypsin, count the cells, dilute the single cell suspension with high-glucose DMEM medium to the required cell concentration of 5×104 / ml, 100 μl per well, Seed in 96-well cell plates at 37°C, 5% CO 2 Cultivate overnight; dilute the sample according to the report, add 100 μl of the sample diluted in serum-free high-glucose DMEM medium to each well, set up blank control group, solvent control group and zero adjustment wells, and set 6 replicate wells for each group, 37 ℃, Continue culturing with 5% CO2, after 24h, 48h, and 72h, carefully remove t...

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Abstract

The invention discloses the application of sinomenine in the preparation process of drugs inhibiting invasion and metastasis of tumors. The application has the benefits as follows: sinomenine can inhibit adhesion, migration, invasion and proliferation of tumor cell lines of the digestive system of people. The results also partially hint that the mechanism for direct inhibition of sinomenine for proliferation and metastatic behavior of the tumor cell lines of the digestive system of people can be the same as the action on epithelial cells. Sinomenine is one of active ingredients in caulis sinomenii that is natural drugs, is rich in source, has very broad medical value, and confirms small side effect, low toxicity, low teratogenic property and the like through research. In the present stage, the drugs effectively resisting metastatic behavior of tumors are lacked at home and abroad. In clinic practice, a great number of patients are doubtless sentenced to death once the patients are diagnosed with the tumors and are complicated with metastasis. Therefore, the application fills a big gap in the field, and can benefit more cancer patients.

Description

technical field [0001] The invention relates to the application of active ingredients of traditional Chinese medicine, in particular to the application of sinomenine in the preparation of drugs for inhibiting tumor invasion and metastasis. Background technique [0002] Sinomenine is the main active alkaloid in the traditional Chinese medicine Qingfengteng, and the research on the chemical constituents of Qingfengteng mainly focuses on sinomenine. The research on the pharmacological effects and clinical application of sinomenine has made considerable progress over the years, and it has been found that sinomenine has significant analgesic, sedative, anti-inflammatory, immunosuppressive, antitussive, histamine-releasing, blood pressure-lowering and anti-inflammatory effects. Arrhythmia and other effects, has been used in the treatment of rheumatism, anti-arrhythmia. In recent years, the anti-tumor effect of sinomenine has gradually attracted attention. More and more studies h...

Claims

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Application Information

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IPC IPC(8): A61K31/485A61P35/04
Inventor 张有成何晶晶
Owner 张有成
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