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Flunarizine hydrochloride and preparation process thereof

A technology of flunarizine hydrochloride and medicine, which is applied in the field of Chinese and Western medicine preparations for treating epilepsy, can solve the problems of large toxic and side effects, insignificant effect, easy rebound and the like, and achieves rational and orderly formulation, deep and lasting drug effect, The effect of good treatment

Active Publication Date: 2012-07-18
仁和堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its purpose is to solve the treatment of intractable epilepsy, overcome the problems of Western medicine flunarizine hydrochloride, which has no significant effect, is easy to rebound, and has serious side effects, so as to achieve the goal of treating both symptoms and root causes

Method used

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  • Flunarizine hydrochloride and preparation process thereof
  • Flunarizine hydrochloride and preparation process thereof
  • Flunarizine hydrochloride and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A compound flunarizine hydrochloride pharmaceutical composition is characterized in that it is prepared from the following raw materials in weight proportions: 0.7 parts of flunarizine hydrochloride, 25 parts of salvia miltiorrhiza, 20 parts of Sanleng, 18 parts of zedoary, 15 parts of Gastrodia elata 10 parts, 10 parts of Ligustrum lucidum.

[0032] Wherein said flunarizine hydrochloride can be purchased commercially, and preferred preparation method is:

[0033] 1. Feeding ratio

[0034]

[0035] 2. Production process

[0036] 2.1 Preparation of difluorophenylchloromethane: Dry the 300L reaction tank slightly, add zinc chloride and concentrated hydrochloric acid, stir, dissolve with natural heat release, after complete dissolution, add difluorobenzyl alcohol, heat, and control the temperature React at 60-70°C for 1 hour, cool down to 30°C, add toluene for extraction three times, collect fractions at 170-180°C under reduced pressure to obtain 30.3 kg of difluoroph...

Embodiment 2

[0044] clinical information

[0045] A total of 101 outpatients with complete medical records were selected. Among them, there were 52 males and 49 females; aged 21 to 61 years, including 46 cases of generalized tonic-clonic seizures, 24 cases of myoclonic seizures, 16 cases of complex partial seizures, 5 cases of simple partial seizures, and 5 cases of absence seizures. There were 3 cases of Lennox-Gastaut syndrome and 2 other cases. Most of them took two or more drugs, including phenytoin, sodium valproate, carbamazepine, phenobarbital, clonazepam, and topiramate. The patients were balanced and randomly divided into 2 groups according to specific conditions such as gender, age, condition, and medication, 36 cases in the treatment group, 35 cases in the control group, and 30 cases in the positive control group.

[0046] Epilepsy Diagnostic Criteria

[0047] TCM syndrome diagnostic criteria: (1) wind-phlegm blockage syndrome: before the attack, there are auras such as chest ...

Embodiment 3

[0058] typical embodiment

[0059] Yuan, male, 9 years old, suffered from epilepsy since he was 7 years old, with seizures ranging from 3 to 5 times per month, and he sought medical treatment for more than 2 years of recurrent seizures. Seizures manifest as generalized partial seizures. The anti-epileptic treatment failed with nitroazepam, sodium valproate, Lamictal, Trilex, and phenobarbital successively. During the attack, there was screaming, foaming at the mouth, twitching of the hands and feet, unconsciousness, eyes turned up, phlegm whine in the throat, urinary incontinence, and woke up after about 5 to 10 minutes. Usually, it is induced in case of fright and fever. Immediate diagnosis: clear mind, good spirit, slightly slow reaction, cardiopulmonary auscultation (1), soft abdomen, liver and spleen not palpable, no positive signs in neurological examination. Brain CT (1), EEG examination showed sharp-slow complex waves. Body of the tongue is light red, fur is greasy ...

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Abstract

The invention relates to compound flunarizine hydrochloride and a preparation process thereof. The compound flunarizine hydrochloride is prepared from the following raw materials in part by weight: 0.7 part of flunarizine hydrochloride, 25 parts of root of red-rooted salvia, 20 parts of common burreed rhizome, 18 parts of zedoary, 15 parts of tall gastrodia tuber and 10 parts of glossy privet fruit, starch live edible cellulose serving as a pharmaceutic adjuvant are added according to the conventional pharmaceutic method to prepare formulations such as capsules, tablets, granules and the like. The compound flunarizine hydrochloride medicinal composition addresses both root causes and symptoms on epilepsy, is non-toxic and harmless to human bodies, does not have side effect, is low in costand easy and convenient to prepare, and has a bright application prospect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a Chinese and Western medicine preparation for treating epilepsy, in particular to the application of a medicine made of the western medicine flunarizine hydrochloride supplemented by Chinese herbal medicine in epilepsy. Background technique [0002] Epilepsy (Epilepsy, EP) is a recurrent, short-term brain dysfunction syndrome caused by temporary excessive high-frequency discharge of brain neurons. It is manifested as sudden onset, automatic termination, and recurrent disturbances in movement, sensation, spirit, and consciousness. It is a chronic convulsive disease. According to incomplete statistics, the current incidence of epilepsy in my country is about 6‰, with nearly 9 million patients, and there are about 450,000 new patients every year. Most studies have found that the incidence of epilepsy in men is 57.1%, which is higher than that in women (42.7%), and the...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P25/08A61K31/495
Inventor 赵振桥聂昌盛张玉美徐平田王丽娟杜宾芳
Owner 仁和堂药业有限公司
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