8-azabicyclo[3.2.1]octane-8-carboxamide derivative

A technology of cycloalkyl and A-1, which is applied in the field of pharmaceutical compositions, and can solve problems such as having different structures and not having 8-azabicycles
CN102596949AInactive Publication Date: 2012-07-18SUMITOMO DAINIPPON PHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SUMITOMO DAINIPPON PHARMA CO LTD
Publication Date
2012-07-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

Disclosed is a compound represented by formula (1) or a pharmacologically acceptable salt thereof. (In the formula, A represents a group that is represented by formula (A-1); R1a and R1b may be the same or different and each independently represents a C1-6 alkyl group which may be substituted by one to three halogen atoms; m and n each independently represents an integer of 0-5; X1 represents a hydroxyl group or an aminocarbonyl group; Z1 represents a single bond or the like; and R2 represents an optionally substituted C1-6 alkyl group, an optionally substituted C6-10 aryl group or the like.)
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Description

technical field

[0001] The present invention relates to 8-azabicyclo[3.2.1]octane-8-carboxamide derivatives, or pharmaceutically acceptable salts thereof, which can be used as medicines. The present invention also relates to a pharmaceutical composition, including 8-azabicyclo[3.2.1]octane-8-carboxamide derivative or a pharmaceutically acceptable salt thereof. The present invention also relates to a therapeutic or preventive agent for glucocorticoid-related diseases, or an inhibitor of 11β hydroxysterol dehydrogenase type I enzyme (hereinafter referred to as 11βHSD1 ) comprising the compound. Background technique

[0002] Glucocorticoids regulate peripheral glucose metabolism and amino acid metabolism. In humans, glucocorticoids are produced in the adrenal glands, and additionally, it is metabolized in peripheral tissues such as adipose tissue or liver. Because 11βHSD1 is an enzyme that converts inactive cortisol into activated cortisol and is mainly expressed in adipose t...

Claims

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