Injectable active bone repair material and preparation method thereof

A technology for bone repair and activity, applied in medical science, prosthesis, etc., can solve the problems of limited amount of natural BMP-2 and difficulty in exerting life activities.

Inactive Publication Date: 2012-07-25
北京博恩康生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the amount of natural BMP-2 is limite

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Mix 5g of α-calcium sulfate hemihydrate (CSH) with a particle size of less than 20μm, 5g of hydroxyapatite with a particle size of less than 50μm, and 0.5mg of BMP-2 active polypeptide to obtain mixture A, and mix distilled water and mixture A with 0.4ml The ratio of / g is fully mixed to obtain the desired bone repair material.

Embodiment 2

[0026] After mixing 3g of α-calcium sulfate hemihydrate (CSH) with a particle size of less than 30 μm, 2 g of hydroxyapatite with a particle size of less than 20 μm, and 3 mg of BMP-2 active polypeptide to obtain mixture A, mix distilled water with mixture A at a rate of 0.3ml / g The ratio is fully mixed to obtain the desired bone repair material.

Embodiment 3

[0028] After mixing 3g of α-calcium sulfate hemihydrate (CSH) with a particle size of less than 800nm, 1g of hydroxyapatite with a particle size of less than 20μm, and 10mg of BMP-2 active polypeptide to obtain mixture A, mix 3wt% alginic acid solution with mixture A by The ratio of 0.3ml / g was mixed thoroughly to obtain the desired bone repair material.

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Abstract

The invention provides an injectable active bone repair material and a preparation method thereof. The material is characterized by comprising a mixture of calcium sulfate hemihydrate, hydroxyapatite and BMP (bone morphogenetic proteins)-2 active peptide, and a curing liquid, wherein the weight ratio of calcium sulfate hemihydrate to hydroxyapatite to BMP-2 active peptide is (0.1-10000):(0.1-10000):0.1; and the dosage range of the curing liquid is 0.01-20ml for per gram of the mixture of calcium sulfate hemihydrate, hydroxyapatite and BMP-2 active peptide. The preparation method is characterized in that the pulpy injectable active bone repair material can be obtained by fully stirring and mixing the mixture with the curing liquid. The preparation method is simple in formula and the preparation process is practical; and the required repair material can be prepared within 24 hours, has good injectability, is cured within half an hour, is simple to prepare, has good biocompatibility and has the characteristics of low temperature, low vacuum, low energy consumption and low pollution.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a resorbable bone repair material with simple preparation, good biocompatibility and remarkable effect and a preparation method thereof. Background technique [0002] Bone defect has always been a difficult problem in orthopedics. In recent years, with the development of minimally invasive surgery, injectable bone substitute (IBS) has attracted more and more attention from scholars from all over the world, and has become one of the research hotspots of biomaterials today. Injectable calcium sulfate bone substitute and calcium phosphate bone substitute are the most commonly used calcium-phosphorus system materials, which are easy to operate and have good biocompatibility. They can be injected into bone defects and solidified in situ to adapt to bone defects for shaping . But both have shortcomings. The absorption of injectable calcium sulfate bone substi...

Claims

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Application Information

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IPC IPC(8): A61L27/50A61L27/54A61L27/12
Inventor 甘少磊
Owner 北京博恩康生物科技有限公司
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