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Anti-lung cancer alstonia-leaf traditional Chinese herbal composite, method for preparing same and application thereof in preparing anti-lung cancer medicine

A technology for anti-lung cancer drugs and compositions, which can be used in drug combinations, anti-tumor drugs, pharmaceutical formulations, etc., and can solve problems such as no anti-lung cancer drugs.

Active Publication Date: 2012-08-15
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, in the prior art, the research on extracting anti-tumor drugs from the leaves of the lampstand is still preliminary, and there are no reports of specific drugs that can be industrialized, let alone reports on the specific use of anti-lung cancer drugs extracted from the leaves of the lampstand.

Method used

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  • Anti-lung cancer alstonia-leaf traditional Chinese herbal composite, method for preparing same and application thereof in preparing anti-lung cancer medicine
  • Anti-lung cancer alstonia-leaf traditional Chinese herbal composite, method for preparing same and application thereof in preparing anti-lung cancer medicine
  • Anti-lung cancer alstonia-leaf traditional Chinese herbal composite, method for preparing same and application thereof in preparing anti-lung cancer medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0099] Embodiment 1, anti-lung cancer traditional Chinese medicine composition, the preparation steps are as follows: step (1): take 1000g of lampstand leaves and use 10 times the amount of 85% ethanol to reflux extract twice, each time for 2h, recycle the solvent, and obtain the extraction concentrate; step ( 2): Put the extract concentrate on the AB-8 type macroporous resin, first wash away the impurities with 4BV of water and 40% ethanol of 4BV, then elute with 60% ethanol of 6BV, and collect the 60% ethanol eluate , reclaim ethanol to obtain the total alkaloid components, and finally elute with 6BV of 80% ethanol, collect the 80% ethanol eluate, reclaim the ethanol, obtain the total triterpene components, and vacuum-dry them respectively to obtain the total alkaloids and total alkaloids. Triterpene components. Step (3): Combine the total alkaloid and total triterpene components in the step (2) according to the crude drug amount of 1:1 to obtain the anti-lung cancer traditi...

Embodiment 2

[0101] Example 2 is basically the same as Example 1, but with the following changes: Step (1): Take 1000g of the lampstand leaf and extract it 4 times with 6 times the amount of 95% ethanol under reflux, each time for 1h, and recover the solvent to obtain the extraction concentrate. Step (2): Put the extract concentrate on the HPD400A macroporous resin, first wash away impurities with 2BV of water and 2BV of 20% ethanol, then elute with 4BV of 50% ethanol, and collect the 50% ethanol eluate , reclaim ethanol to obtain the total alkaloid components, and finally elute with 4BV of 70% ethanol, collect the 70% ethanol eluate, reclaim the ethanol, obtain the total triterpene components, and vacuum-dry them respectively to obtain the total alkaloids and total alkaloids. Triterpene components. Step (3): Combine the total alkaloid and total triterpene components in the step (2) according to the crude drug amount of 1:0.1 to obtain the anti-lung cancer traditional Chinese medicine comp...

Embodiment 3

[0103] Embodiment 3 is basically the same as Embodiment 1, but has the following changes: Step (1): Get 1000g of the lampstand leaf and use 8 times the amount of 80% ethanol to reflux extract 3 times, each 1.5h, reclaim the solvent, and obtain the extraction concentrate . Step (2): Put the extract concentrate on the NKA-9 type macroporous resin, first wash away impurities with 3BV of water and 30% ethanol of 3BV, then elute with 55% ethanol of 5BV, collect 55% ethanol to wash Deliquification, recovery of ethanol, to obtain the total alkaloid components, and finally elute with 5BV of 95% ethanol, collect the 95% ethanol eluate, recover ethanol, obtain the total triterpene components, vacuum dry respectively, to obtain the total alkaloids and total triterpenes. Step (3): Combine the total alkaloid and total triterpene components in the step (2) according to the crude drug amount of 1:10 to obtain the anti-lung cancer traditional Chinese medicine composition of the present inven...

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Abstract

The invention discloses an anti-lung cancer alstonia-leaf traditional Chinese herbal composite, a method for preparing the same and an application thereof in preparing an anti-lung cancer medicine. The raw material of the composite is traditional Chinese herbal alstonia-leaf. The composite consists of total alkaloids ingredient and total triterpenoids ingredient in alstonia-leaf extract; and the total alkaloids ingredient and the total triterpenoids ingredient are respectively mixed according to the mass ratio 1 / 0.1-1 / 10 of the crude dose of the raw material. The invention further provides the method for preparing the anti-lung cancer alstonia-leaf traditional Chinese herbal composite and the application of the anti-lung cancer alstonia-leaf traditional Chinese herbal composite in preparing the anti-lung cancer medicine. The anti-lung cancer alstonia-leaf traditional Chinese herbal composite has a good tumor inhibitory effect on C57BL / 6 tumor-bearing mice, can obviously improve the immunity of the mice, compared with cyclophosphamide, the alstonia-leaf composite can obviously improve the immune factor (thymus index, spleen index and liver index) of the tumor-bearing mice and the interval cell factor (tumor necrosis factor (TNF)-a and interleukin (IL)-6) of the mice, thus having stronger anti-cancer activity, lower toxic and side effects, a safe and reliable curative effect, and being an effective anti-cancer medicine.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition of Dengtai leaves for anti-lung cancer, its preparation method and its application in the preparation of anti-lung cancer medicine. Background technique [0002] Under the influence of environmental pollution, occupational exposure and other factors, the incidence of lung cancer continues to rise worldwide, and it has become the most harmful malignant tumor to human health. In my country's cities, lung cancer accounts for 17.8% of all tumor deaths, and has risen to the first place in the ranking of malignant tumor incidence. According to the 2010 China Health Statistical Yearbook, the mortality rate of lung cancer in urban China in 2009 was 49.6 / 100,000, and the mortality rate of rural lung cancer was 39.64 / 100,000, accounting for 29.2% and 24.7% of cancer deaths respectively. In urban areas, 1 in every 4 deaths is from canc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/40A61P35/00A61K127/00
Inventor 陈彦刘璇张振海杜萌
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE