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Lanthanum-doped hydroxyapatite compound coating and preparation method thereof

A technology of hydroxyapatite and composite coating, applied in the direction of coating, electrolytic inorganic material coating, etc., can solve problems such as unreported, and achieve the effects of low cost, simple process, and not easy to be absorbed

Inactive Publication Date: 2012-08-15
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no report on the preparation of lanthanum-doped hydroxyapatite composite coatings

Method used

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  • Lanthanum-doped hydroxyapatite compound coating and preparation method thereof
  • Lanthanum-doped hydroxyapatite compound coating and preparation method thereof
  • Lanthanum-doped hydroxyapatite compound coating and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Weigh 0.99 g of Ca(NO 3 ) 2 4H 2 O is dissolved in 100ml distilled water to obtain the calcium nitrate aqueous solution that concentration is 0.042mol / L, takes by weighing 0.246 gram (NH 4 )H 2 PO 4 Dissolve in 100ml of distilled water to obtain an aqueous ammonium dihydrogen phosphate solution with a concentration of 0.025mol / L, take the same volume of calcium nitrate aqueous solution and ammonium dihydrogen phosphate aqueous solution, and add the calcium nitrate aqueous solution to the ammonium dihydrogen phosphate aqueous solution dropwise. During the process, the pH value of the mixed solution is controlled to 4.4, and the supersaturated hydroxyapatite solution is obtained by stirring evenly.

[0025] Electrochemical deposition preparation of hydroxyapatite coating: pure titanium or titanium alloy Ti 6 al 4 The V substrate was used as the cathode, and the metal platinum sheet was used as the cathode, and was electrochemically deposited at a voltage of 3V for 1...

Embodiment 2

[0028] Weigh 0.99 g of Ca(NO 3 ) 2 4H 2 O is dissolved in 100ml distilled water to obtain the calcium nitrate aqueous solution that concentration is 0.042mol / L, takes by weighing 0.246 gram (NH 4 )H 2 PO 4 Dissolve in 100ml of distilled water to obtain an aqueous ammonium dihydrogen phosphate solution with a concentration of 0.025mol / L, take the same volume of calcium nitrate aqueous solution and ammonium dihydrogen phosphate aqueous solution, and add the calcium nitrate aqueous solution to the ammonium dihydrogen phosphate aqueous solution dropwise. During the process, the pH value of the mixed solution is controlled to 4.4, and the supersaturated hydroxyapatite solution is obtained by stirring evenly.

[0029] Electrochemical deposition preparation of hydroxyapatite coating: pure titanium or titanium alloy Ti 6 al 4 The V substrate was used as the cathode, and the metal platinum sheet was used as the cathode, and was electrochemically deposited at a voltage of 6V for 1...

Embodiment 3

[0032] Weigh 0.99 g of Ca(NO 3 ) 2 4H 2 O is dissolved in 100ml distilled water to obtain the calcium nitrate aqueous solution that concentration is 0.042mol / L, takes by weighing 0.246 gram (NH 4 )H 2 PO 4 Dissolve in 100ml of distilled water to obtain an aqueous ammonium dihydrogen phosphate solution with a concentration of 0.025mol / L, take the same volume of calcium nitrate aqueous solution and ammonium dihydrogen phosphate aqueous solution, and add the calcium nitrate aqueous solution to the ammonium dihydrogen phosphate aqueous solution dropwise. During the process, the pH value of the mixed solution is controlled to 4.4, and the supersaturated hydroxyapatite solution is obtained by stirring evenly.

[0033] Electrochemical deposition preparation of hydroxyapatite coating: pure titanium or titanium alloy Ti 6 al 4 The V substrate was used as the cathode, and the metal platinum sheet was used as the cathode, and was electrochemically deposited at a voltage of 5V for 3...

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Abstract

The invention relates to a lanthanum-doped hydroxyapatite compound coating and a preparation method thereof, and particularly, aims at providing an active coating with high stability in body fluid simulation and a preparation method thereof. The preparation method comprises the steps of: preparing calcium nitrate aqueous solution and ammonium dihydrogen phosphate aqueous solution, controlling pH, adding dropwise and mixing, and then uniformly stirring to obtain electrolyte; preparing a hydroxyapatite coating by means of electrochemical deposition in the case that titanium or titanium alloy matrix is used as anode and platinum sheet is used as cathode; and soaking the hydroxyapatite coating in lanthanum nitrate for a certain period of time, taking out the sample and drying to obtain the lanthanum-doped hydroxyapatite compound coating. The compound coating disclosed by the invention has the characteristics that hydroxyapatite is doped with lanthanum through soaking treatment, thus the stability of the coating in body fluid simulation is improved and the coating is seldom absorbed, as a result, the coating disclosed by the invention is applicable for the repair of various bones.

Description

Technical field: [0001] The invention relates to a lanthanum-doped hydroxyapatite composite coating and a preparation method thereof, belonging to the preparation technology of biological coating materials. Background technique: [0002] Hydroxyapatite (Hydroxyapatite, built as HA) is a good bioactive material. Coating hydroxyapatite coating on the surface of titanium alloy, the composite material obtained in this way not only has the excellent mechanical properties of titanium alloy, but also has the excellent biocompatibility and bioactivity of hydroxyapatite bioceramics, and has become the research field of biomaterials. One of the hot spots. At present, there are more than ten methods of coating hydroxyapatite coating on the surface of titanium alloy, such as plasma spraying method, laser cladding method, electrodeposition, electrophoresis method and sol-gel method. Since the stability of hydroxyapatite in body fluid is not very high, and it is easy to be absorbed, as ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/32C25D9/08
Inventor 周宏明胡建中易丹青肖来荣李荐杨伏良刘会群
Owner CENT SOUTH UNIV