Oil-in-water type compound geranium oil nanometer milk composition

A geranium oil, oil-in-water type technology, applied in the field of medicine, can solve the problems of difficult skin penetration and absorption, water and oil incompatibility, high viscosity of essential oils, etc., and achieve the effect of promoting wound healing, reducing scars, and softening the skin

Inactive Publication Date: 2012-08-22
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, due to the immiscibility of water and oil, traditional geranium oil, evening primrose oil, juniper oil, neroli oil and lavender oil are simple extracts, and some essential oils have high viscosity and are not easy to penetrate and absorb

Method used

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  • Oil-in-water type compound geranium oil nanometer milk composition

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0037] Experimental example 1 Observation on the curative effect of guinea pig eczema

[0038] In this experiment, by constructing an animal experimental model, guinea pig eczema is used to simulate human eczema, and the compound geranium nanoemulsion composition of the present invention is administered to observe its effect.

[0039] 1.1 Test method

[0040]Take 25 healthy female guinea pigs aged 4 to 5 weeks (the Experimental Animal Center of our school), weighing 220. 5±32. 95 g, and remove the hair on both sides of the back of each mouse in 4 places, with an area of ​​2 cm × 3 cm per place. Anesthetized by intraperitoneal injection of pentobarbital according to body weight; intradermal injection of OVA 10 μg + Al (OH) 3 0.5 mg on the depilated area; 1 week later, with 3 cm × 4 cm gauze, coated with 10% OVA + 10% SDS + 30% Vaseline + 50% water, stick it on the depilated area for 48 hours; 3 weeks after intradermal injection, apply 10% OVA + 5% SDS + 37% Vaseline + 3...

experiment example 3

[0055] Experimental Example 3 Observation on the Curative Effect of Compound Nanoemulsion Composition on Treatment of Female Menstrual Syndrome

[0056] Premenstrual syndrome is a general term for various discomfort symptoms that occur before menstruation. Physically, there will be breast tenderness, head, neck and back pain, increased appetite, craving for sweets, fatigue and laziness, etc. In terms of mental state, there may be listlessness, depression, nervousness, irritability, or insomnia. Generally, women will have some different feelings more or less before menstruation. If it is more serious, it will cause problems in family life or work, and even suicidal tendencies. There is no specific medicine for PMS on the market at present, and most of them improve symptoms through folk prescriptions or maintenance methods, which have no therapeutic effect.

[0057] Through the drug administration experiment on 30 women who have the above symptoms before menstruation for...

Embodiment 1

[0061] Weigh 1.6g of geranium oil, 1.6g of evening primrose oil, 1.1g of juniper oil, 0.5g of neroli oil, and 0.6g of lavender oil, mix and stir well; add 35.7g of Tween-80 into the mixture and mix again, stir well , then slowly add 58.9g of distilled water dropwise to the mixture, and stir while adding, the mixture system will appear a series of changes from thin to viscous, and finally from viscous to thin, until an oil-in-water type nanoemulsion.

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PUM

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Abstract

The invention discloses an oil-in-water type compound geranium oil nanometer milk composition. The particle diameter of the composition is 1-100nm. The composite is composed of the following raw materials by weight percentage: 28.5%-42.1% of a surfactant, 0.01%-5.6% of geranium oil, 0.01%-4.6% of evening primrose seed oil, 0.01%-2.8% of cade oil, 0.01%-1.4% of orange flower oil, 0.01%-1.4% of lavender oil and balanced distilled water. The sum of the mass percentage of the raw materials is 100%. The oil-in-water type compound geranium oil nanometer milk composite can obviously treat dermatitis, eczema and pale scar and can alleviate premenstrual syndrome to different degrees, improves biological utilization degree of essential oil, enhances pharmacological activity of the essential oil, enables the essential oil to be strong in permeability, good in stability, durable in acting time and obvious in effect, and has wide market prospect in the field of medicines.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a new dosage form of compound geranium oil nanoemulsion composition which can antibacterial and anti-inflammatory, improve skin inflammation, repair scars, and relieve premenstrual syndrome, in particular to a clear and transparent oil-in-water compound geranium oil nanoemulsion milk composition. [0002] Background technique [0003] Pelargonium graveolens is a perennial subshrub of the genus Geranium in the family Geraniaceae. The whole herb can be used as medicine, with acrid taste and warm nature. It also has the effects of pain relief, antibacterial, penetrating into scars, enhancing cell defense, deodorizing, hemostasis, and replenishing the body. Suitable for all skin types, it has deep purifying and astringent effects, and balances sebum secretion. Promote skin cell regeneration, repair scars and stretch marks. The pharmacological effects of its essential oils have been studied ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61K9/107A61P17/00A61P15/00
Inventor 欧阳五庆兰莹王辉玲
Owner NORTHWEST A & F UNIV
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