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Asymmetric double-crosslinked composite material, as well as preparation method and application of same

A composite material, asymmetric technology, applied in the field of medical materials, can solve the problems of poor mechanical strength and changes of pure sodium hyaluronate, and achieve the effects of good toughness and adhesion performance, good adhesion and convenient operation

Active Publication Date: 2012-08-29
佛山市领固胶粘科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to further improve the shortcomings of pure sodium hyaluronate, such as poor mechanical strength, and the effect is affected by changes in the patient's position. The present invention utilizes sodium hyaluronate and chitosan to inhibit the biological performance of fibroblasts, and uses sodium hyaluronate With chitosan and its derivatives as the main raw materials, a composite membrane material with smooth, dense and porous rough two asymmetric surfaces is prepared by physical-chemical double cross-linking. A material that suppresses scars in the initial stage of skin wound healing

Method used

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  • Asymmetric double-crosslinked composite material, as well as preparation method and application of same
  • Asymmetric double-crosslinked composite material, as well as preparation method and application of same
  • Asymmetric double-crosslinked composite material, as well as preparation method and application of same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Adjust the pH of 10mL hyaluronic acid solution with a concentration of 1% (wt) to 10, and slowly add it dropwise to 10mL chitosan solution with a concentration of 1% (wt) under magnetic stirring at a mass ratio of 1:1 , mix evenly, add 0.015g genipin and stir evenly to obtain A solution.

[0032] Pour solution A into the mold and let it stand for 1 hour to form a film at 50°C. After the film was formed, it was neutralized with ammonia gas, and placed in a -80°C refrigerator for precooling for 10 minutes. The solution A was quickly poured onto the pre-cooled composite membrane and frozen in a -80°C refrigerator for 2 hours, then freeze-dried, neutralized with ammonia gas, and sealed for storage.

[0033] The asymmetric composite membrane material prepared by this method is light green, with a maximum tensile strength of 0.37 MPa, a tensile modulus of 12.45 MPa, and a maximum tensile rate of 15%. Scanning electron microscope observation as image 3 As shown, the front ...

Embodiment 2

[0035] Adjust the pH of 10mL hyaluronic acid solution with a concentration of 1% (wt) to 10, and slowly add it dropwise to 10mL chitosan solution with a concentration of 1% (wt) under magnetic stirring at a mass ratio of 1:1 , and mix well to obtain A solution.

[0036] Adjust the pH of 10mL of 1% (wt) hyaluronic acid solution to 10, slowly add it dropwise to 10mL of 1% (wt) 2-hydroxypropyl Trimethylammonium chloride chitosan solution, mixed evenly to obtain B solution.

[0037] Pour solution A into the mold and let it stand for 1 hour to form a film at 50°C. After the film was formed, it was neutralized with ammonia gas, and placed in a -80°C refrigerator for precooling for 10 minutes. Pour solution B quickly onto the pre-cooled composite membrane and freeze in a -80°C refrigerator for 2 hours, then lyophilize, neutralize with ammonia gas, and store in a sealed container.

[0038] The asymmetric composite membrane material prepared by this method is white, with a maximum t...

Embodiment 3

[0040] Adjust the pH of 10mL hyaluronic acid solution with a concentration of 1% (wt) to 9, and slowly add it dropwise to 10mL chitosan solution with a concentration of 2% (wt) under magnetic stirring at a mass ratio of 1:2 , and mix well to obtain A solution.

[0041] Adjust the pH of 10 mL of 0.5% (wt) hyaluronic acid solution to 10, and slowly add it dropwise to 10 mL of 0.5% (wt) hydroxymethyl chitosan under magnetic stirring at a mass ratio of 1:1. Sugar solution, mix well to get B solution.

[0042] Pour solution A into the mold and let it stand for 1 hour to form a film at 50°C. After the film was formed, it was neutralized with ammonia gas, and placed in a -80°C refrigerator for precooling for 10 minutes. Pour solution B quickly onto the pre-cooled composite membrane and freeze in a -80°C refrigerator for 2 hours, then lyophilize, neutralize with ammonia gas, and store in a sealed container.

[0043]The asymmetric composite membrane material prepared by this method ...

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Abstract

The invention discloses an asymmetric double-crosslinked composite material, as well as a preparation method and the application of the material. The asymmetric double-crosslinked composite material is obtained by preparing sodium hyaluronate / chitosan composite material into an asymmetric surface material with a smooth surface and a spongy surface, has good hydrophilicity, water absorbency, water storability and breathability, has the functions of promoting growth of epithelial cells and endothelial cells and inhibiting growth of fibroblasts, has a wide antibacterial effect, and has a wide application prospect in the field of medical care.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to an asymmetric double-crosslinked composite material and its preparation method and application. Background technique [0002] Skin damage caused by burns and trauma often leaves scars, and the hyperplasia of scars affects the appearance of patients, and the resulting pain, itching and burning sensation cause huge physical and psychological pain to patients. If certain treatment is given at the early stage of wound healing, focusing on inhibiting the growth of fibroblasts, the formation of scars can be largely inhibited or even eliminated. [0003] Hyaluronic acid (HA) has obvious inhibitory effect on fibroblasts. There is no scar after the fetal skin tissue wound is repaired. It is found in medicine that HA rises rapidly after fetal skin injury and lasts for a long time. After adult skin injury, HA increases transiently, but HA cannot be detected after 3 days. HA is a negativel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/14
Inventor 周长忍李立华叶碧华陈洁苏嘉豪周宸
Owner 佛山市领固胶粘科技有限公司
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