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Forsythia suspense soft capsule, preparation method and application thereof

A technology of soft capsules and forsythia seeds, applied in the field of medicine, can solve the problem of not finding forsythia seeds, etc., and achieve the effects of improving stability, stable and reliable process, and preventing loss.

Inactive Publication Date: 2012-09-19
山西振东五和堂制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no related preparations of Forsythia Fructus have been found in the market

Method used

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  • Forsythia suspense soft capsule, preparation method and application thereof
  • Forsythia suspense soft capsule, preparation method and application thereof
  • Forsythia suspense soft capsule, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Preparation of the capsule shell:

[0041] (1) According to the ratio of gelatin: glycerin: water: sorbitol 5:2:5:3, take sorbitol and add it into water and stir to dissolve it, put it in a plastic tank together with glycerin, and heat to 70-80°C;

[0042] (2) Add gelatin under stirring state, and wait to dissolve, take the pigment of 0.2-0.4% of the total amount of materials in step (1), add a small amount of water to dissolve, add in the glue solution, and stir evenly;

[0043] (3) Vacuumize to remove air bubbles, and keep warm at 60-70°C for 4-12 hours.

Embodiment 2

[0045] Prescription: Forsythia Seed Active Ingredient C 1375g

[0046] soybean oil 4800g

[0047] Beeswax 325g

[0048] (1) Get 18kg of Fructus Forsythiae, add 160L of water, steam distillation extracts volatile substances, repeat 3 times, the time is 3 hours, 2 hours, 1 hour respectively, after the extraction is completed, combine the volatile substances, airtight storage, to obtain 275g Extract A;

[0049] (2) Combine the water extracts in (1), filter, concentrate the filtrate under reduced pressure at 60°C to a relative density of 1.05-1.10, let it cool, add ethanol to make the alcohol content 80%, leave it overnight, and take the supernatant Liquid decompression recovery ethanol, until the concentration of the concentrated solution contains 1.0g of crude drug per ml, filter, put AB-8 macroporous adsorption resin on the filtrate, control the flow rate to 0.5 ~ 1.5BV / h, first use 5BV of water to remove impurities, Then eluted with 2BV80% ethanol, collected the...

Embodiment 3

[0055] Prescription: Forsythia Seed Active Ingredient C 1735g

[0056] Sesame oil 1465g

[0057] Peanut oil 3000g

[0058] Beeswax 300g

[0059] (1) Get 23 kg of Forsythia chinensis, add 185 L of water, steam distillation to extract volatile substances, repeat 3 times, the time is 3 hours, 2 hours, 1 hour respectively, after the extraction is completed, combine the volatile substances, airtight storage, to obtain 347g Extract A;

[0060] (2) Combine the water extracts in (1), filter, concentrate the filtrate under reduced pressure at 60°C to a relative density of 1.05-1.10, let it cool, add ethanol to make the alcohol content 80%, leave it overnight, and take the supernatant Liquid decompression recovery ethanol, until the concentration of the concentrated solution contains 1.0g of crude drug per ml, filter, put AB-8 macroporous adsorption resin on the filtrate, control the flow rate to 0.5 ~ 1.5BV / h, first use 5BV of water to remove impurities, Then elut...

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Abstract

The invention relates to a forsythia suspense soft capsule, and a preparation method and application thereof, and belongs to the technical field of medicines. The forsythia suspense soft capsule is composed of 20-50% of active ingredients and 50-80% of auxiliary materials in the capsule, the active ingredients comprise extract A and B, and the auxiliary materials in the capsule are composed of 70-97% of dispersing agents and 3-30% of suspending agents. The preparation method of the forsythia suspense soft capsule comprises the steps of taking forsythia suspense, extracting volatile substances for 3 times through steam distillation, combining the volatile substances, carrying out airtight storage, and obtaining the extract A; combining aqueous extract solution, carrying out decompression concentration to filtrate, adding ethanol, taking supernatant to decompress and recycle ethanol, concentrating, filtering, enabling filtrate to be processed through macroporous resin, rinsing and removing impurities, utilizing ethanol to carry out elution, collecting eluent, carrying out decompression and concentration, and obtaining the extract B by drying and grinding; combining the A and the B, and obtaining the active ingredients C; heating and melting the dispersing agents and the suspending agents, stirring, adding the C, and obtaining contents of the soft capsule by processing through screen cloth with over 100 mesh; weighing gelatin, water, plasticizers and pigments, and preparing a capsule shell; and obtaining the soft capsule by pressing. Experiments show that the active ingredients of the soft capsule have the effects of antipyresis, anti-inflammation and analgesia and have new application to therapy of exogenous febrile diseases.

Description

technical field [0001] The invention relates to a forsythia soft capsule, a preparation method and application of the soft capsule, and belongs to the technical field of medicine. Background technique [0002] Forsythia suspensa (Thunb.) Vahl, a plant in the Oleaceae family, is a commonly used heat-clearing and detoxifying drug in traditional Chinese medicine. It has always been regarded as an important medicine for sores. It is slightly cold in nature and bitter in taste. Forsythia is one of the traditional Chinese medicines commonly used in clinical practice in China. Modern pharmacological studies have shown that Forsythia has antibacterial, cardiotonic, diuretic, and antiemetic pharmacological effects. It is often used to treat acute wind-heat cold, carbuncle sore, lymph node tuberculosis, and urinary tract infection It is the main raw material of other traditional Chinese medicine preparations. Most of the traditional Chinese medicine preparations related to forsythia ...

Claims

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Application Information

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IPC IPC(8): A61K36/634A61K9/48A61K47/44A61P11/04A61P11/14A61P29/00A61P31/14A61K131/00
Inventor 玄振玉陈叶明黄孝春
Owner 山西振东五和堂制药有限公司
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