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Gulose tablet excipient, medicine tablet and preparation method of medicine tablet

A technology of gulose tablets and excipients, applied in the field of medicine, can solve the problems of high brittleness and cannot be pressed into tablets, etc., and achieves the effects of high hydrophilicity, good formability, and avoiding agglomeration and agglomeration

Inactive Publication Date: 2013-07-10
安吉东来药用辅料有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In Example 8, ordinary microcrystalline cellulose was used as an excipient to carry out tablet compression of disodium clometris phosphate tablet. When the tablet compression speed reached 30,000 tablets / hour, the friability was as high as 38%. When reaching 50000 tablets / hour, then can not be compressed into tablet, carry out the disodium clomedipate tablet tabletting with silicified microcrystalline cellulose as excipient, when the tabletting speed reaches 50000 tablets / hour, although the tablet is still Maintain good strength, but the brittleness reaches 2.5%, and the brittleness is still high

Method used

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  • Gulose tablet excipient, medicine tablet and preparation method of medicine tablet
  • Gulose tablet excipient, medicine tablet and preparation method of medicine tablet
  • Gulose tablet excipient, medicine tablet and preparation method of medicine tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] A kind of anhydrous disodium clometris phosphate medicine tablet, adopts the raw material of following percentage by weight:

[0043]

[0044] Gulose, starch octenyl succinate, silicon dioxide and kaolin are dried and crushed together, passed through a 1mm sieve, then added with anhydrous disodium chloroformate and water, mixed evenly, and used in a tableting device at 9× 20mm punching machine, made into anhydrous chlormedate disodium pharmaceutical tablets with an average weight of 1190mg (±2%).

Embodiment 2

[0046] A kind of anhydrous disodium clometris phosphate medicine tablet, adopts the raw material of following percentage by weight:

[0047]

[0048] Gulose, starch octenyl succinate, silicon dioxide and kaolin are dried and crushed together, passed through a 1mm sieve, then added with anhydrous disodium chloroformate and water, mixed evenly, and used in a tableting device at 9× 20mm punching machine, made into anhydrous chlormedate disodium pharmaceutical tablets with an average weight of 1190mg (±2%).

[0049] Prepare the anhydrous chlormedipate disodium pharmaceutical tablet (tablet A) of embodiment 1 and the anhydrous chlormedipate disodium pharmaceutical tablet (tablet B) of embodiment 2 under different tabletting speeds, and investigate Its crushing strength and fragility, the specific test results are shown in Table 1. The test of tablet crushing strength and friability refers to the method specified in the French Pharmacopoeia (10th edition in 1993, V.5.1) "Friabil...

Embodiment 3

[0054] A kind of anhydrous disodium clometris phosphate medicine tablet, adopts the raw material of following percentage by weight:

[0055]

[0056] Gulose, starch octenyl succinate, silicon dioxide and kaolin are dried and crushed together, passed through a 1mm sieve, then added with anhydrous disodium chloroformate and water, mixed evenly, and used in a tableting device at 9× 20mm punching machine, made into anhydrous chlormedate disodium pharmaceutical tablets with an average weight of 1190mg (±2%).

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Abstract

The invention discloses gulose tablet excipient, which consists of the following ingredients in percentage by weight: 88 percent to 96 percent of gulose, 1 percent to 5 percent of starch octenyl succinate anhydride, 1 percent to 5 percent of silicon dioxide and 1 percent to 5 percent of porcellanite, and has the advantages that the mobility is good, the forming degree is good, the demolding performance is good, and the gulose tablet excipient can be directly tableted with medicine and water for preparing medicine tablets. The invention also discloses a medicine tablet, which is prepared from the following ingredients in percentage by weight: 75 percent to 85 percent of medicine active ingredients, 5 percent to 15 percent of gulose tablet excipient and 5 percent to 15 percent of water raw materials, wherein the gulose tablet excipient and the medicine active ingredients do not have incompatibility and reaction, in addition, the solvability is good, the flowability is good, and the medicine tablet is suitable for the direct tableting of various kinds of medicine. The invention also discloses a preparation method of the medicine tablet, which has the advantages that the preparation is simple, the implementation is easy, and the operation and the control are easy.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a gulose tablet excipient which can be directly compressed into tablets and is easy to flow, a drug tablet and a drug tablet prepared by using the gulose tablet excipient The preparation method of the agent. Background technique [0002] Tablet accounts for more than one-third of all pharmaceutical dosage forms and is a very important pharmaceutical dosage form. Excipients play a vital role in drug stability and absorption efficiency, and are the core of drug tablet making. Appropriate tablet excipients are required to be safe, non-toxic, have no side effects, have no incompatibility or reaction with the main drug, and have good fluidity, so that the main drug can be dispersed evenly and have a large adsorption force to the main drug. It is suitable for direct tablet compression. The prepared tablet has the advantages of high adhesion, good formability, good lubricity, good mold release...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/36A61K47/26A61K47/04A61K9/20
Inventor 李青青阮晖吴慧斌刘松柏陈放诸文颖
Owner 安吉东来药用辅料有限责任公司
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