Bicyclic dihydropyrazole compounds

Abstract

The invention belongs to the field of pharmaceutical technology, in particular to bicyclic dihydropyrazole compounds shown in a general formula (I), pharmaceutically acceptable salts or isomers of the bicyclic dihydropyrazole compounds, pharmaceutical preparations of the pharmaceutically acceptable salts or isomers, and application of the bicyclic dihydropyrazole compounds and the pharmaceutically acceptable salts or isomers to preparation of drugs used for treating and / or preventing renal injury and / or hypertension. Cy1, L, X, Y1, Y2, n1, n2, n3, n4, R1a, R1b, R2a, R2b, R3a, R3b, R4, R5, R13, R14 and m are defined in the patent specification.

Description

1. Technical field

[0001] The present invention belongs to the technical field of medicine, and specifically relates to a dihydropyrazole compound containing a ring, its pharmaceutically acceptable salt or its isomer, and the pharmaceutical preparation of these compounds' pharmaceutically acceptable salt or its isomer. And the application of these compounds, their pharmaceutically acceptable salts or their isomers in the preparation of medicines for treating and / or preventing kidney damage and / or hypertension. 2. Background technology

[0002] Primary kidney disease, secondary kidney disease such as diabetic nephropathy, renal insufficiency and other kidney damage diseases, clinically manifested as a large amount of proteinuria, if not treated in time, it will lead to renal failure. There are many causes of kidney damage, such as diabetes, high blood pressure and other common diseases can lead to kidney damage. For example, 15% to 25% of patients with type 1 diabetes and 30...

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