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Method for synthesizing amino functionalized rare earth-doped lanthanum fluoride nano fluorescent marker material

A rare earth doping and amino synthesis technology, applied in luminescent materials, chemical instruments and methods, analytical materials, etc., can solve problems such as limiting the practical application of nanomaterials, affecting the efficiency of biological detection and analysis, affecting the luminescent properties of nanocrystals, etc. The conditions are easy to control, the particles are uniform, and the size is small.

Inactive Publication Date: 2012-09-19
FUJIAN INST OF RES ON THE STRUCTURE OF MATTER CHINESE ACAD OF SCI
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  • Summary
  • Abstract
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  • Application Information

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Problems solved by technology

Not only the obtained nanoparticles are relatively large (generally 30-50 nm), which affects the efficiency of subsequent biological detection and analysis; but also in order to achieve the water solubility of nanoparticles, further methods such as surface silanization or colloidal electrostatic adsorption of organic polymers are required. take surface modification
Obviously, the subsequent surface functionalization treatment increases the synthesis steps, and the re-treatment of the surface of nanoparticles will also affect the luminescent properties of nanocrystals. These factors limit the practical application of nanomaterials.

Method used

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  • Method for synthesizing amino functionalized rare earth-doped lanthanum fluoride nano fluorescent marker material
  • Method for synthesizing amino functionalized rare earth-doped lanthanum fluoride nano fluorescent marker material
  • Method for synthesizing amino functionalized rare earth-doped lanthanum fluoride nano fluorescent marker material

Examples

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Effect test

example 1

[0024] Example 1: Weigh 0.07 g of AEP, dissolve it in 30 mL of distilled water to obtain a transparent solution, then adjust the pH value to 6 with ammonia water, then add 0.126 g of NaF to it, stir to dissolve it completely, and obtain solution A, keep it warm in 30℃; another 0.424 g La(NO 3 ) 3 ·6H 2 O and 0.009 g Eu(NO 3 ) 3 ·6H 2 O was completely dissolved in 5 mL of distilled water to obtain a transparent solution B; under stirring, solution B was added dropwise to solution A, and stirring was continued for 20 hours to obtain a transparent solution. Then, 50 mL of acetone was added to the solution to precipitate nanocrystals, which were centrifuged, washed with water and ethanol several times, and then dried under vacuum at 60°C to obtain LaF 3 : 2% Eu nanocrystalline powder. The obtained nanocrystalline powder is dissolved in water to obtain a colorless and transparent aqueous solution. It is detected with a spectrometer, and under the excitation of 394 nm, strong...

example 2

[0025] Example 2: Weigh 0.14 g of AEP, dissolve it in 30 mL of distilled water to obtain a transparent solution, then adjust the pH value to 7 with ammonia water, then add 0.168 g of NaF to it, stir to dissolve it completely, and obtain solution C, which is kept at 60℃; another 0.346 g La(NO 3 ) 3 ·6H 2 O, 0.065 g Ce(NO 3 ) 3 ·6H 2 O and 0.023 g Tb(NO 3 ) 3 ·6H 2 O was completely dissolved in 5 mL of distilled water to obtain a transparent solution D; under stirring, solution D was added dropwise to solution C, and stirring was continued for 20 hours to obtain a transparent solution. Then 50 mL of acetone was added to the solution to precipitate nanocrystals, which were centrifuged, washed with water and ethanol several times, and then dried under vacuum at 60°C to obtain LaF 3 : 15%Ce, 5%Tb nanocrystalline powder. The obtained nanocrystalline powder is dissolved in water to obtain a colorless and transparent aqueous solution. Using a spectrometer for detection, unde...

example 3

[0026] Example 3: Weigh 0.28 g of AEP, dissolve it in 30 mL of distilled water to obtain a transparent solution, then adjust the pH value to 8 with ammonia water, then add 0.21 g of NaF to it, stir to dissolve it completely, and obtain solution E, keep it warm in 90℃; another 0.216 g La(NO 3 ) 3 ·6H 2 O and 0.228 g Dy(NO 3 ) 3 ·6H 2 O was completely dissolved in 5 mL of distilled water to obtain a transparent solution F; under stirring, solution F was added dropwise to solution E, and stirring was continued for 20 hours to obtain a transparent solution. Then 50 mL of acetone was added to the solution to precipitate nanocrystals, which were centrifuged, washed with water and ethanol several times, and then dried under vacuum at 60°C to obtain LaF 3 : 50% Dy nanocrystalline powder.

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Abstract

The invention relates to a method for synthesizing an amino functionalized rare earth-doped lanthanum fluoride nano fluorescent marker material, which comprises the steps of: with phosphorylethanolamine as a surface active agent, mixing sodium fluoride, lanthanum nitrate and rare earth nitrate in distilled water, carrying out heat preservation at the temperature of 30-90 DEG C, and stirring for a period of time, washing and drying to obtain the aminated rare earth-doped lanthanum fluoride nanocrystalline with the component of xLn<3+>-(1-x) LaF3, wherein Ln<3+>=Ce<3+>, Yb<3+>, Er<3+>, Tm<3+>, Ho<3+>, Eu<3+>, Gd<3+>, Tb<3+>, Dy<3+>, Sm<3+>, Nd<3+> and Pr<3+>, and x=0-50mol%. The rare earth-doped LaF3 nano fluorescent marker material prepared by the method has the advantages that the size of nanoparticles can be controlled to be about 5nm, water solubility is good and the surface amino can be used to realize the connection with biomolecule. Furthermore, different rare earth ions can be doped into the nanoparticles, so that the specific fluorescence emission can be realized so that the biological connection can be detected sensitively; and the nano fluorescent marker material prepared by the method has the potential in application in the biological marking field.

Description

technical field [0001] The invention relates to a method for synthesizing a water-soluble inorganic nano-fluorescence marking material, in particular to a preparation method for a rare-earth-doped lanthanum fluoride nano-fluorescence marking material with amino functionalization. Background technique [0002] Inorganic rare earth nanocrystals have been widely used in the fields of green lighting sources, nano-optoelectronic devices, and flat panel displays, but they have not attracted much attention as fluorescent biomarkers until recent years. At present, the materials widely used in fluorescent biomarkers are organic dyes, fluorescent proteins, rare earth chelates, organic chromophore-doped silica gel / latex nanobeads, semiconductor quantum dots, and inorganic rare earth nanocrystals. Among them, compared with other labeling materials, inorganic rare earth nanocrystals are widely used due to their comprehensive advantages such as high photochemical stability, almost non-tox...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/85G01N21/64G01N33/533
Inventor 陈学元涂大涛刘丽琴刘永升朱浩淼
Owner FUJIAN INST OF RES ON THE STRUCTURE OF MATTER CHINESE ACAD OF SCI
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