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New use of Primula sikkmensis Hook or extract thereof

A technology of bellflower primrose and extract, which is applied in the field of medicine to achieve the effects of realizing industrialized production, improving utilization rate and saving production cost

Inactive Publication Date: 2012-09-26
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no report on the use of ethanol extract or total flavonoids of Primula bellflower for anti-angiogenesis

Method used

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  • New use of Primula sikkmensis Hook or extract thereof
  • New use of Primula sikkmensis Hook or extract thereof
  • New use of Primula sikkmensis Hook or extract thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 The preparation of the ethanol extract of Bellflower and Primrose of the present invention

[0023] Take the coarse powder of Primula bellflower, add 20 times the amount of 60% ethanol to soak, reflux extraction 3 times, each time for 1 hour, combine the filtrates, recover to dryness under reduced pressure, and obtain the ethanol extract of Primula bellflower.

Embodiment 2

[0024] Embodiment 2 The preparation of the total flavonoids of Bellflower Primrose of the present invention

[0025] Take the coarse powder of bell flower and primrose, add 20 times the amount of 60% ethanol to soak, heat and reflux for extraction 3 times, each time for 1 hour, combine the filtrate, recover under reduced pressure until there is no alcohol smell, add an appropriate amount of distilled water, and extract with n-butanol After recovering the n-butanol solution under reduced pressure until there is no n-butanol smell, add an appropriate amount of distilled water to dissolve, and after filtering, the pretreated D101 macroporous adsorption resin on the filtrate is first eluted with distilled water until no ferric chloride reaction and React with magnesium hydrochloride powder, then elute with 30% ethanol, collect the eluate until no reaction between ferric chloride and magnesium hydrochloride powder occurs, combine the eluent, recover the solvent, and dry to obtain th...

Embodiment 3

[0027] Example 3 Screening of the preparation method of total flavonoids from Primula bellflower

[0028] 1. Determination method of total flavonoids content

[0029] 1.1 Preparation of reference solution

[0030] Take 0.01006g of rutin reference substance, put it in a 50ml volumetric flask, add 60% ethanol to make it up to the mark, and prepare a reference substance solution with a concentration of 0.2012mg / ml for future use.

[0031] 1.2 Preparation of sample solution

[0032] Transfer the extracted extract prepared according to each preparation method to a 100ml volumetric flask, and set the volume to the mark, accurately pipette 10ml from this solution in the 100ml volumetric flask, and set the volume to the scale with 60% ethanol to obtain the sample solution. spare.

[0033] 1.3 Determination of measurement wavelength

[0034] Precisely pipette 7ml of the reference solution and 2ml of the test solution, place them in two 25ml volumetric flasks, add 60% ethanol to dil...

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PUM

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Abstract

The invention discloses a use of Primula sikkmensis Hook or an extract of the Primula sikkmensis Hook in preparing a medicine for restraining angiogenesis. The Primula sikkmensis Hook and an ethanol extract and general flavone of the Primula sikkmensis Hook are good in angiogenesis inhibiting action and can be used as an angiogenesis inhibitor, and a new selection is provided for the medicine for clinical cancer treatment. Meanwhile, the pharmacological activities of the general flavone and the ethanol extract of the Primula sikkmensis Hook are equivalent to that of single compounds (such as quercetin and 5-hydroxyflavone) contained in the Primula sikkmensis Hook and are even higher, therefore, the single compounds do not need to be separated and purified any longer when the medicine is used in the later stage, thus, not only is the production cost of the medicine saved but also the use ratio of medicinal materials is increased. The invention is in favor of realizing the industrial production of the medicine.

Description

technical field [0001] The invention relates to a new application of primrose bellflower or its extract, and belongs to the field of medicine. Background technique [0002] Primary tumor growth and metastasis are dependent on angiogenesis (Augiogenesis). The tumor itself has the ability to initiate and promote angiogenesis to meet the needs of its own metabolism and nutrient supply, and continuously transport metastatic cells to the host through blood vessels, and continue to grow and induce angiogenesis in other parts of the body, resulting in tumor metastasis. Without angiogenesis, the primary tumor will not grow beyond 1-2 mm, and will not invade and metastasize. Not only solid tumors need to rely on angiogenesis, but also hematological malignancies, such as malignant lymphoma, leukemia, etc., the growth and metastasis of these tumors are also closely related to angiogenesis. [0003] Not only that, but angiogenesis is also one of the basic events in many other patholo...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P35/00A61K133/00
Inventor 彭腾邓赟邱建平陈裕贺钢民李鸿翔
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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