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Magnesium Danshensu and its preparation method and use

A technology of danshensu and magnesium salt, which is applied in the field of medicine, can solve the problems of ignoring the contribution of magnesium ions and destroying the action of inorganic ions, etc., and achieves the effects of strong druggability, good curative effect and high yield

Inactive Publication Date: 2012-10-10
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the past, people ignored the contribution of magnesium ions to the activity of Danshen, especially the acid-base treatment in the preparation process of the previous Danshen compound preparations would destroy the action of inorganic ions.

Method used

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  • Magnesium Danshensu and its preparation method and use
  • Magnesium Danshensu and its preparation method and use
  • Magnesium Danshensu and its preparation method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: the preparation of danshensu magnesium

[0023] (1) Preparation method

[0024] Take 2kg of dried root of Salvia miltiorrhiza, add water to boil twice, filter, concentrate to thick paste. Add ethanol until the alcohol content of the solution is 70-80%, cool, filter, and concentrate to extract. Take Danshen paste and dissolve it in water, filter and extract the aqueous solution with ethyl acetate, and concentrate to obtain ethyl acetate paste. Perform silica gel column layer, elute with different ratios of chloroform-acetone-formic acid, and collect corresponding fractions to obtain Danshensu. Dissolve Danshensu in ethanol, adjust the pH value to 6.8, add magnesium chloride solution dropwise, recover a small amount of ethanol, and leave at room temperature to precipitate white solid Danshensu magnesium salt, which can be recrystallized or purified by column chromatography with a yield of 2-3‰.

[0025] (2) Characterization data

[0026] Such as f...

Embodiment 2

[0031] Embodiment 2: Pharmacodynamic experiment of danshensu magnesium

[0032] experiment material: Sixty-four Sprague-Dawley male rats, weighing (230±20) g, provided by the Experimental Animal Center of Fourth Military Medical University; creatine kinase (CK), superoxide dismutase (SOD), malondialdehyde reagent (MDA) , nitric oxide test kit (NO), glutathione peroxidase test kit (GSH-P X ), xanthine oxidase test kit (XOD). The kit is a product of Nanjing Jiancheng Institute of Biology.

[0033] , Pharmacodynamic study on myocardial ischemia-reperfusion injury

[0034] Preparation of myocardial ischemia-reperfusion model

[0035] The 32 rats were randomly divided into 4 groups: sham operation group; reperfusion group; Danshensu group (30mg / kg); Danshensu magnesium group (30mg / kg). The administration group was administered (jugular vein injection) 10 minutes before ischemia, and the dose was determined according to the pharmacodynamic curve of the new drug.

[0036...

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Abstract

The invention discloses magnesium Danshensu and its preparation method and use. The magnesium Danshensu is a drug for preventing and treating cardiovascular and cerebrovascular diseases. The preparation method has the advantages of easily available raw materials, simple processes and high yield. The magnesium Danshensu has a good structure, good curative effects, low toxicity and strong druggability.

Description

technical field [0001] The invention relates to danshensu magnesium salt, a preparation method thereof and an application in preparation of medicines for treating angina pectoris, coronary heart disease, cerebral infarction and cardiocerebral ischemia / reperfusion injury, belonging to the technical field of medicine. Background technique [0002] According to the statistics of the World Health Organization, the mortality rate of cardiovascular and cerebrovascular diseases ranks first, with an annual death toll of 17.5 million, accounting for 30% of all deaths. Therefore, it is a difficult problem to be solved urgently in today's medical circle to find the medicine of high-efficiency treatment heart, cerebrovascular disease. [0003] For thousands of years, Salvia miltiorrhiza has been an important component of traditional Chinese medicine for the treatment of cardiovascular and cerebrovascular diseases. skin), "Compound Danshen Dripping Pills" (Danshen, Panax notoginseng and...

Claims

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Application Information

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IPC IPC(8): C07C59/52C07C51/41A61P9/00A61P9/10
Inventor 文爱东孙晓莉陈雷奚苗苗熊立泽权伟
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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