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Novel compound donkey-hide glue extract powder formula, preparation and application of novel compound donkey-hide glue extract powder formula

A technology of compound donkey-hide gelatin and extract powder, which is applied in the direction of medical formulas, medical preparations containing active ingredients, plant raw materials, etc., which can solve the problems of weakening vaginal self-cleaning effect, prone to inflammation, iatrogenic infection, etc., and achieve prevention The effect of re-bleeding infection, avoiding re-ascending infection, and shortening the course of myogenic treatment

Inactive Publication Date: 2012-10-17
钱乐群
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, after all kinds of nursing douches became popular, it was found that douching with vaginal douching liquid every day, or even douching several times, on the contrary, the reproductive tract is more prone to inflammation than before douching, and it is more likely to cause repeated attacks. Washing the vagina with a disinfectant solution destroys the normal protective flora of the vagina, leading to an imbalance of the flora and weakening the original self-cleaning effect of the vagina. At the same time, the pathogenic bacteria cannot be correctly judged after using the lotion; However, there is a vaginal douche on the market that can be used by patients at home. Because it is not disposable, it is easy to cause iatrogenic infection due to equipment contamination, which brings difficulties to doctors and often delays the diagnosis and treatment. illness
As for the introduction of foreign Lip Knife equipment technology, Orlok gynecological minimally invasive cervical repair system, although the effect is good, the damage to the surface of the cervix is ​​less than that of microwave, laser, and electrocautery methods, less bleeding, no scars and other sequelae of injury , and the repair is uniform, known as the "mother of ablation knife", but the cost is too expensive, and it is still easy to relapse, especially the problem that still cannot be solved is: all patients with bacterial and mold infection in the genital tract at the same time, after using all instruments Before traumatic treatment, the principle of the original international regulations must still be strictly followed, that is, vaginal mycosis must be routinely and completely cured first, reaching three courses of treatment (each course of treatment is one month, and the mold test is negative for three consecutive times). Three courses of treatment have a total of 9 tests , are all negative, can be considered cured, and then can consider minimally invasive surgical treatment of cervicitis
[0007] Chinese patent application 200510025337.9 "An External Pharmaceutical Preparation for the Treatment of Pelvic Inflammation" discloses a Chinese medicine compound external preparation (effervescent tablet and suppository) for the treatment of pelvic inflammatory disease on the basis of the 8815365.1 patent. Similarly, the extract powder of the original external prescription of traditional Chinese medicine is still used to administer the animal experiment through the vaginal route to obtain curative results. There are irritants when taking medicines. For this deficiency, effervescent tablets have been specified in the clinical "Clinical Trial Approval Document" of this medicine, and the "Approval Document" has already exceeded the implementation time limit within three years and has been abolished.
Therefore, the traditional Chinese medicine compound external preparation (effervescent tablet and suppository) of 200510025337.9 cannot be used in clinical practice and has no practicability

Method used

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  • Novel compound donkey-hide glue extract powder formula, preparation and application of novel compound donkey-hide glue extract powder formula
  • Novel compound donkey-hide glue extract powder formula, preparation and application of novel compound donkey-hide glue extract powder formula
  • Novel compound donkey-hide glue extract powder formula, preparation and application of novel compound donkey-hide glue extract powder formula

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation method of embodiment one compound donkey-hide gelatin extract powder

[0027] According to the difference of yin and yang, qi and blood and according to the severity of damp-heat symptoms, prepare the following different proportions of raw materials:

[0028] Prescription 1: 45 parts of Ejiao, 35 parts of Astragalus, 12 parts of Codonopsis; 24 parts of Salvia, 24 parts of Polyporus, 22 parts of Poria, 25 parts of Radix Paeoniae Rubra, and 3 parts of Puhuang.

[0029] Prescription 2: 30 parts of Ejiao, 0 parts of Astragalus, 35 parts of Codonopsis; 15 parts of Salvia, 6 parts of Polyporus, 18 parts of Poria, 15 parts of Radix Paeoniae Rubra, and 15 parts of Puhuang.

[0030] Prescription 3: 22 parts of donkey-hide gelatin, 22 parts of astragalus, 0 part of Codonopsis pilosula; 18 parts of salvia miltiorrhiza, 16 parts of polyporus, 12 parts of poria cocos, 17 parts of red peony, and 12 parts of Puhuang.

[0031] Prescription 4: 20 parts of donkey-hide ge...

Embodiment 2

[0041] Example 2 Study on the therapeutic effect of new compound donkey-hide gelatin extract powder administered through vaginal route

[0042] (1) Study on the therapeutic effect of new compound donkey-hide gelatin extract powder on acute pelvic inflammatory disease in rats

[0043] 1. Experimental drugs

[0044] 1.1 Name: New compound donkey-hide gelatin extract powder (the name used for the test: jj-0808, prepared from the prescription in Example 1), brown, and the dosage for humans is 1.5-2g / person (calculated according to the extract powder of raw materials).

[0045] 1.2 Positive control drug: Fule Granules, produced by Sichuan Baoguang Pharmaceutical Co., Ltd., 6g x bag, 12g each time, twice a day, take with boiling water. Oral administration (ig), animal dosage 2.4g / kg.

[0046] 1.3 Other drugs

[0047] Ketamine hydrochloride injection, specification: 2ml: 0.18 / ×10 sticks, Jiangsu Hengrui Medicine Co., Ltd.

[0048] Xinwei brand iodophor disinfectant, Jiangsu Xingh...

Embodiment 3

[0147] Example 3 Study on the protective effect of the extract of the present invention on lung injury caused by rabbit oleic acid

[0148] 1. Experimental Drugs

[0149] 1. Luoantai JJ0908 (also called JJ0908 in this practice) (internal use) (extract of the present invention) brown extract containing extract powder 0.47g / mL

[0150] 2. Luoantai JJ0808 (also known as JJ0808 in this implementation) (control) (original technical prescription) brown extract powder

[0151] 3. Oleic acid chemically pure from Shanghai Lingfeng Chemical Reagent Co., Ltd.

[0152] 2. Experimental animals

[0153] New Zealand white rabbits (2.1-2.3kg, half male and half male, 40 rabbits) provided by Nanjing Anlimo Technology Co., Ltd.;

[0154] 3. Animal experiment conditions:

[0155] Experimental site: Animal Laboratory Building, Nanjing Medical University

[0156] Animal laboratory: temperature 20-24 ℃, humidity 40-70%

[0157] 4. Experimental method

[0158] 5.1 Pre-experiment

[0159]5.1....

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Abstract

The invention provides novel compound donkey-hide glue extract powder which is suitable for oral administration and external use, wherein the novel compound donkey-hide glue extract powder is prepared from crude medicine materials by weight as follows: 10-45 parts of donkey-hide glue, 0 part or 6-35 parts of codonopsis root, 0 part or 6-35 parts of astragalus root, 5-24 parts of salvia root, 6-24 parts of polyporus, 6-22 parts of tuckahoe, 5-25 parts of red peony root and 3-22 parts of cattail pollen, wherein the content of the astragalus root and the content of the codonopsis root are not 0 part at the same time. According to the invention, the time for playing a low recurrence function in the prior art is prolonged, and the pharmaceutical effect is more stable. Besides, the improved oral prescription extract has a function of protecting lung injury in rabbits induced by oleic acid, the prescription is simplified, the process is simple and convenient, the energy resource is saved, the social and economic benefits are increased, and the international initiative level of the original technology is improved to a higher level.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a new compound donkey-hide gelatin traditional Chinese medicine extract and its preparation method and application, including the traditional Chinese medicine prescription for oral or external use. Background technique [0002] 1. The latest research developments at home and abroad: [0003] After entering the 21st century, the incidence of women's lower reproductive tract infection is still increasing year by year, which is as common as the common cold. The epidemiology of female reproductive tract infection, the study of pathogens, and the study of chlamydia and mycoplasma infection have already attracted worldwide attention. In particular, mycoplasma and chlamydia have become the pathogens of sexually transmitted diseases that have gradually increased in recent years. They invade the cervix and vagina, causing erosion and bleeding and purulent secretions, especial...

Claims

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Application Information

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IPC IPC(8): A61K36/88A61P11/00A61P15/00A61P17/02
Inventor 程孝慈
Owner 钱乐群
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