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Liuwei dihuang dripping pills

A technology of Huangdiwan and Rehmannia glutinosa, which is applied in the field of traditional Chinese medicine preparations, can solve the problems of difficult precise control of blood drug concentration and ineffective pharmacological effects of drugs, and achieve the effects of high roundness, high hardness, and efficient pharmacological effects

Inactive Publication Date: 2012-10-17
JIANGSU EHAI PHARMA CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the dissolution time of the above two kinds of drop pills is scattered between 5 and 60 minutes, which makes it difficult to accurately control the blood drug concentration at a specific time point, and makes it impossible for the drug to exert its pharmacological effects quickly and efficiently.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1. Take Rehmannia glutinosa 1408g, Cortex Moutan 528g, Chinese yam 704g, Cornus officinalis 704g, Alisma 528g and Poria cocos 528g;

[0024] 2. Take 110g of Poria cocos and crush it into fine powder, sieve the remaining part and decoct the remaining Poria cocos with water for three times, 30 minutes each time, filter, combine the filtrate, concentrate to a thick paste; add ethanol to reflux extraction twice, each time for 1 hour , filter, the dregs are set aside, the filtrate recovers ethanol, concentrates to a thick paste; Moutan cortex is steam distilled, and 1mol / L hydrochloric acid solution is added to the collected distillate to crystallize, filter, wash the crystal with water, and dry at low temperature. Grind into a fine powder; distilled aqueous solution, Moutan Cortex dregs, Cornus officinalis dregs, rehmannia glutinosa, Chinese yam, and Alisma alisma, add water and decoct three times, each time for 1 hour, filter, combine the filtrate, pass through the macropor...

Embodiment 2

[0029] 1. Take Rehmannia glutinosa 1408g, Cortex Moutan 528g, Chinese yam 704g, Cornus officinalis 704g, Alisma 528g and Poria cocos 528g;

[0030] 2. Take 350g of Poria cocos and grind it into fine powder; add ethanol to reflux and extract twice, each time for 1 hour, filter, and use the dregs for later use. The filtrate recovers ethanol and concentrates to a thick paste; Moutan bark is steam distilled, and the distillate is added with 1mol / L hydrochloric acid solution to crystallize, and set aside; the distilled aqueous solution, Moutan cortex dregs, Cornus officinalis dregs, remaining Poria cocos, rehmannia glutinosa, yam, and Alisma chinensis are decocted in water three times, each time for 1 hour, filtered, and the filtrates combined, Concentrate to a thick paste; add the above-mentioned fine powder of Poria cocos and thick paste of Cornus officinalis, mix well, dry at low temperature, crush into fine powder, add the above-mentioned Moutan Cortex extract, and mix well to ...

Embodiment 3

[0035] 1. Take Rehmannia glutinosa 1408g, Cortex Moutan 528g, Chinese yam 704g, Cornus officinalis 704g, Alisma 528g and Poria cocos 528g;

[0036] 2. Take 350g of Poria cocos and grind it into fine powder; add ethanol to reflux and extract twice, each time for 1 hour, filter, and use the dregs for later use. The filtrate recovers ethanol and concentrates to a thick paste; Moutan bark is steam distilled, and the distillate is added with 1mol / L hydrochloric acid solution to crystallize, and set aside; the distilled aqueous solution, Moutan cortex dregs, Cornus officinalis dregs, remaining Poria cocos, rehmannia glutinosa, yam, and Alisma chinensis are decocted in water three times, each time for 1 hour, filtered, and the filtrates combined, Concentrate to a thick paste; add the above-mentioned fine powder of Poria cocos and thick paste of Cornus officinalis, mix well, dry at low temperature, crush into fine powder, add the above-mentioned Moutan Cortex extract, and mix well to ...

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Abstract

The present invention discloses Liuwei dihuang dripping pills, which are prepared by adopting an extract as a raw material and adopting a carrier as a dripping pill matrix, wherein the extract is extracted from 6 traditional Chinese drugs of prepared rhizome of rehmannia, cornel, tree peony root-bark, common yam rhizome, oriental waterplantain tuber, and tuckahoe, a weight ratio of the extract powder of the 6 traditional Chinese drugs to the matrix is 1:1-8, the extract powder of the 6 traditional Chinese drugs is prepared by adopting the method specified in the pharmacopoeia or the ministry authorized standard, the dripping pill matrix is polyethylene glycol with the weight average molecular weight of 6000 and the viscosity distribution of 13.6-14.5, and the content of the polyethylene glycol with the molecular weight of 6000 in the total polyethylene glycol is 40-60%. The Liuwei dihuang dripping pills of the present invention have characteristics of high spherical degree and high hardness, and the dissolution-dispersion time is controlled to 5-15 minutes, such that the drug can really, rapidly and efficiently play pharmacological effects.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation. Background technique [0002] Liuwei Dihuang Pill is composed of Rehmannia glutinosa, Cornus officinalis, Chinese yam, Cortex Moutan, Alisma and Poria cocos. It can be seen from the compatibility of medicines that it combines kidney yin with liver and spleen, and mainly kidney yin. Existing Liuwei Dihuang preparations include honeyed pills, watered pills, concentrated pills, tablets, hard capsules, soft capsules, oral liquids, granules, dripping pills, etc. Among these preparations, dripping pills are characterized by their high bioavailability and rapid drug release. , Quick and effective, less toxic and side effects, and easy to use and carry, it occupies a large market share. [0003] Disclosed in CN1247241C is a kind of Liuwei Dihuang dripping pill, and its matrix selects polyethylene glycol 1500~10000, stearic acid, sodium stearate, glycerin gelatin, glyceryl monostearate, shell...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61K47/34A61K9/20A61P1/14
Inventor 王凤越张艳侠
Owner JIANGSU EHAI PHARMA CORP
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