Anti-skin squamous cell carcinoma medicament, i.e., antagomir-365-2

A squamous cell carcinoma and skin technology, applied in the field of biomedicine, can solve problems such as difficulty in gene therapy, achieve good stability, inhibit invasion and metastasis, and inhibit and eliminate tumor mass.
CN102755651AInactive Publication Date: 2012-10-31SOUTHERN MEDICAL UNIVERSITY
2 Cites 2 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SOUTHERN MEDICAL UNIVERSITY
Publication Date
2012-10-31
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses an anti-skin squamous cell carcinoma medicament, i.e., antagomir-365-2. The antagomir-365-2 is a chemically-modified antisense oligonucleotide of which the nucleotide sequence is shown as SEQIDNO:1 in which two continuous basic groups at a 5' end and four continuous basic groups at a 3' end are modified with thiophosphoric acid, the 3' tail end is marked with cholesterol, and all basic groups are modified through methylation. The anti-skin squamous cell carcinoma medicament, i.e., antagomir-365-2 disclosed by the invention can be enriched on a target cell by overcomingthe obstacles of cell membranes, tissues and the like, can directly enter cells cultured in vitro and in-vivo tumorigenesis tissues, is an ideal medicament for performing in-vitro and in-vivo skin squamous cell carcinoma treatment experiments, and can be used for effectively inhibiting invasion and transfer of tumor cells in vitro and effectively inhibiting growth of tumors and eliminating tumorsin vivo. The antagomir-365-2 disclosed by the invention has a remarkable resisting effect on skin squamous cell carcinoma, and is a target gene medicament for treating skin cancers.
Need to check novelty before this filing date? Find Prior Art

Description

Technical field

[0001] The present invention is a biomedical field, which involves an anti-skin squamous cell carcinoma drug Antagomir-365-2. Background technique

[0002] As one of the common malignant tumors in white races, skin cancer has a total incidence of incidence exceeding all other malignant tumors. In recent years, its incidence rate has risen year by year and showed youthful.According to the initial international agreement on restricting the consumption of ozone substances, by 2100, the incidence of skin cancer in the northwest of Europe and the American skin cancer may double, and 2060 will lead to a 10%growth peak.

[0003] At present, the clinical treatment of skin cancer is still dominated by surgery, radiotherapy, laser and other comprehensive treatment. Today, the pathogenic genes of skin cancer have been successfully confirmed at the molecular level.But how to find tumor targeted therapy genes and genetic treatment on it is still a big problem.

[0004] In rece...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More