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Ginkgo-damole medicinal composition and preparation method thereof

A composition, ginkgo technology, applied in the field of medicine, can solve the problems of secondary pollution, inconvenient use, etc., and achieve the effect of avoiding side effects and drug decomposition

Active Publication Date: 2012-11-28
SHANXI PUDE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, powder injections have their disadvantages, such as inconvenient use and the possibility of secondary pollution during use

Method used

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  • Ginkgo-damole medicinal composition and preparation method thereof
  • Ginkgo-damole medicinal composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Example 1 Preparation of Ginkgo Damole Emulsion (Specification 10ml)

[0061] The emulsion formula is:

[0062] Ginkgo biloba extract 10g (the total flavonoids of ginkgo contained in the extract)

[0063] Dipyridamole 4g

[0064] soybean oil 1400g

[0065] Phospholipids 180g

[0066] Benzyl Benzoate 26g

[0067] Glycerin 220g

[0068] Add water for injection to 10L

[0069] crafting process:

[0070] (1) Add soybean oil into the liquid mixing tank 1, heat in a water bath, and control the temperature at 70-90°C. After reaching the temperature requirement, add benzyl benzoate;

[0071] (2) Continue to fill nitrogen under the liquid level of liquid mixing tank 1, and after adding phospholipids, start high-speed shear stirring;

[0072] (3) Then add ginkgo biloba extract and dipyridamole to the liquid mixing tank 1 in sequence, and stir with high speed shear until all materials are completely dissolved to obta...

Embodiment 2

[0080] The beneficial effect of embodiment 2 benzyl benzoate in the process of preparing ginkgo damo emulsion

[0081] The Ginkgo Damole emulsion sample prepared by Example 1 is designated as Sample A;

[0082] Ginkgo Damole emulsion will be prepared by the process of Example 1, but benzyl benzoate has been deleted in the formula, and the prepared sample is designated as sample B.

[0083] The emulsion sample A and sample B for injection were subjected to an accelerated test, and placed under the conditions of a temperature of 40°C ± 2°C and a relative humidity of 75% ± 5% for 6 months. Samples were taken at the end of the first month, second month, third month, and sixth month of the test period, and the properties, pH value, and active ingredient content were used as the investigation indicators. The results are shown in the table below:

[0084]

[0085] Conclusion: It can be seen from the above table that in sample A with benzyl benzoate added, the total flavonoid gl...

Embodiment 3

[0086] Example 3 Preparation of Ginkgo Damole Emulsion (Specification 5ml)

[0087] The emulsion formula is:

[0088] Ginkgo biloba extract 12g (the total flavonoids of ginkgo contained in the extract)

[0089] Dipyridamole 5g

[0090] soybean oil 1600g

[0091] Phospholipids 220g

[0092] Benzyl Benzoate 30g

[0093] Glycerin 250g

[0094] Add water for injection to 10L

[0095] crafting process:

[0096] (1) Add soybean oil into the liquid mixing tank 1, heat in a water bath, and control the temperature at 70-90°C. After reaching the temperature requirement, add benzyl benzoate;

[0097] (2) Continue to fill nitrogen under the liquid level of liquid mixing tank 1, and after adding phospholipids, start high-speed shear stirring;

[0098] (3) Then add ginkgo biloba extract and dipyridamole to the liquid mixing tank 1 in sequence, and stir with high speed shear until all materials are completely dissolved to obtain liquid Ⅰ;

[0099] (4) Add about 80% of the total a...

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Abstract

The invention relates to a ginkgo-damole medicinal composition for injection, which can be used for preventing and treating the coronary heart disease and the thromboembolic diseases and a preparation method of the ginkgo-damole medicinal composition. The composition consists of ginkgo leaf extract, dipyridamole, soybean oil, phospholipid, benzyl benzoate and glycerin. The use of the benzyl benzoate is beneficial to the quality of the composition. The composition disclosed by the invention solves the problems of low solubility and instability of active ingredients of ginkgo-damole. The composition has a certain slow release and targeting properties, so that the probability and the risk that the medicament has adverse reaction can be reduced and the safety and the effectiveness of the clinical medicine application are improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a ginkgo damole composition for injection and a preparation method thereof. Background technique [0002] Ginkgo biloba is the leaf of Ginkgo biloba plant. Ginkgo biloba leaves are sweet, bitter and astringent in nature, beneficial to the heart and lungs, reducing dampness and relieving diarrhea. "Chinese Medicine Chronicle" records that it can "contract lung qi, relieve asthma and cough, and stop turbidity". According to modern pharmacological research, ginkgo biloba has a wide range of effects on human and animal bodies, such as improving cardiovascular and peripheral vascular circulation, improving myocardial ischemia, promoting memory, and improving brain function. In addition, it can also reduce blood viscosity and scavenge free radicals. [0003] The chemical composition of Ginkgo biloba is complex, and flavonoids and lactones are two major types of compo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61K9/107A61K47/44A61P9/10A61P7/02A61K31/519
Inventor 苏志强李立忠王勇解晓荣李润宝胡成伟
Owner SHANXI PUDE PHARMA CO LTD
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