Beta-cell replication promoting compounds and methods of their use

A technology of β cells and pancreatic cells, applied in biochemical equipment and methods, pancreatic cells, animal cells, etc., can solve the problem of human insulin deficiency, primary β cells do not have the same effect, and reduced pancreatic β cell mass and function And other issues
CN102803474AInactive Publication Date: 2012-11-28PRESIDENT & FELLOWS OF HARVARD COLLEGE +2
45 Cites 3 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
PRESIDENT & FELLOWS OF HARVARD COLLEGE
Publication Date
2012-11-28
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

In the invention provides for a method of stimulating or increasing beta-cell replication or growth, by contacting a beta-cell with an inhibitor of adenosine kinase (ADK), an inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) or an activator of AMP activated protein kinase (AMPK).
Need to check novelty before this filing date? Find Prior Art

Description

[0001] Cross References to Related Applications

[0002] This application claims the benefit under 35 U.S.C. §119(e) of US Provisional Application No. 61 / 288,001 filed December 18, 2009, the contents of which are hereby incorporated by reference in their entirety.

[0003] governmental support

[0004] This invention was made with Government support under Grant Nos. DK072505 and DK084206 awarded by the National Institutes of Health. The US Government has certain rights in this invention. technical field

[0005] The present invention relates to compositions and methods for promoting replication and / or growth of beta cells. Background technique

[0006] There are two forms of diabetes: (1) insulin-dependent diabetes or type 1 diabetes (aka, juvenile onset diabetes, fragile diabetes, insulin-dependent diabetes (IDDM)) and (2) non-insulin-dependent diabetes or 2 type diabetes mellitus (aka NIDDM). Type 1 diabetes most often occurs in adolescents but can occur in adults. Ty...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More