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Therapeutic agent or preventive agent for urine collection disorder

A technology for urinary storage disorder and therapeutic agent, which is applied in the directions of urinary system diseases, medical preparations containing active ingredients, organic active ingredients, etc., to achieve significant therapeutic effects, ensure safety, and reduce side effects.

Active Publication Date: 2015-01-07
TORAY IND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] On the other hand, it has been reported that pyrazole derivatives (Patent Document 2) or cyclohexane derivatives (Patent Document 3) having the following formula having a sulfonyl group on the aromatic ring bonded to the pyrazole ring are Compounds with pain effect, but there is no report showing effect on urinary retention disorder

Method used

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  • Therapeutic agent or preventive agent for urine collection disorder
  • Therapeutic agent or preventive agent for urine collection disorder
  • Therapeutic agent or preventive agent for urine collection disorder

Examples

Experimental program
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preparation example Construction

[0334] The preparation of tablets containing compound (I) may contain excipients, binders, disintegrants, lubricants, etc., and the preparation of pills and granules may contain excipients, binders, disintegrants, etc. to proceed. Powders and capsules can be prepared containing excipients, etc., syrups can be prepared containing sweeteners, etc., and emulsions or suspensions can be prepared containing surfactants, suspending agents, emulsifiers, etc.

[0335] Examples of the above-mentioned excipients include lactose, glucose, starch, sucrose, microcrystalline cellulose, licorice powder, mannitol, sodium bicarbonate, calcium phosphate, and calcium sulfate.

[0336] Examples of the binder include starch gelatinization liquid, gum arabic liquid, gelatin liquid, tragacanth gum liquid, carboxymethyl cellulose liquid, sodium alginate liquid, and glycerin.

[0337] Examples of the above-mentioned disintegrants include starch and calcium carbonate.

[0338] Examples of the aforemen...

Embodiment

[0365] Hereinafter, the present invention will be specifically described based on examples, but the present invention is not limited thereto.

[0366] (For the effect of cyclophosphamide-induced frequent urination model rats)

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Abstract

An object of the present invention is to provide a therapeutic agent or prophylactic agent effective for therapy of urine storage disorders, by which agent improvement of side effects due to an anticholinergic action is attained as well as which agent also has an analgesic effect. The present invention provides a therapeutic agent or prophylactic agent for a urine storage disorder(s), said agent comprising as an effective ingredient a cyclohexane derivative exemplified by the formula below, a pharmaceutically acceptable salt thereof, or a prodrug thereof.

Description

technical field [0001] The present invention relates to a therapeutic or preventive agent for urinary storage disorder. Background technique [0002] Urinary storage disorder is a state in which a sufficient amount of urine cannot be stored in the bladder during storage, and the main symptoms are: frequent urination, urinary incontinence, and urgency. Frequent urination refers to the state of exceeding the normal frequency of urination. Urinary incontinence refers to the involuntary or unconscious leakage of urine, which is a state that causes hygiene and social problems. Urinary urgency refers to a sudden, strong, and unbearable strong urge to urinate. state. Currently, anticholinergics are mainly used as therapeutic agents for urinary storage disorders such as frequent urination, urinary incontinence, or urinary urgency. Anticholinergic drugs are agents that bind to muscarinic receptors to exert receptor antagonistic action (anticholinergic action). [0003] Patients pr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D231/12A61K31/415A61K31/421A61K31/426A61K31/4439A61P13/02A61P43/00C07D263/32C07D277/24C07D401/04
CPCC07D231/12C07D263/32A61K31/421C07D277/24A61K31/4155A61K31/422A61K31/661A61K31/427A61K31/426C07D401/04A61K31/415A61P13/02A61P13/10A61P43/00
Inventor 晴山菜菜吉川悟中尾薰
Owner TORAY IND INC