Continuous gradient composite scaffold and preparation method thereof

Abstract

The invention discloses a continuous gradient composite scaffold, and relates to the field of biomedical materials. The composite scaffold consists of hydrogel and magnetic composite nano particles; the weight percentages of the magnetic composite nano particles at the top and the bottom of the continuous gradient composite scaffold are respectively 0 percent and 10 to 70 percent; the weight percentage of the magnetic composite nano particles is gradually increased from the top of the continuous gradient composite scaffold to the bottom to form continuous gradient distribution; the hydrogel is hydrogel of polyvinyl alcohol and natural polysaccharide; and the magnetic composite nano particles are magnetic composite nano particles of an oxide of nano hydroxyapatite / iron. The continuous gradient composite scaffold improves cell compatibility by adding natural polysaccharide, has high strength and high biocompatibility, and can well meet the multilevel requirement of an osteochondral natural structure. The invention also discloses a preparation method for the continuous gradient composite scaffold. The preparation method is easy to implement and control, and has a broad application prospect.

Description

technical field

[0001] The invention belongs to the field of biomedical materials and their preparation, and in particular relates to a continuous gradient composite support for osteochondral defect repair and a preparation method thereof. Background technique

[0002] Natural osteochondral is a multi-layered structure of cartilage layer, calcified layer and subchondral bone layer. The repair of osteochondral defects by osteochondral tissue engineering has gone through three stages: single-layer scaffold, double-layer scaffold and three-layer scaffold. The design of a single-layer scaffold only considers the upper cartilage layer and ignores the lower bone layer, which is difficult to meet the structural requirements of natural osteochondral. Therefore, it is inevitable to construct a double-layer scaffold to repair osteochondral defects. The double-layer stent considers the bionic simulation of the upper cartilage structure and the lower bone structure, and has achieved cer...