Mupirocin purification method

A mupirocin and purification method technology, which is applied in the field of mupirocin purification, can solve the problems of large amount of organic solvent usage, many extraction steps, and low purity, and achieve energy saving, production cost reduction, and excellent product quality Effect
CN102863433AInactive Publication Date: 2013-01-09BEIJING RENFENG TECH
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING RENFENG TECH
Publication Date
2013-01-09
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention discloses a mupirocin purification method and belongs to biotechnology. A high-purity mupirocin product is obtained by using structural characteristics of mupirocin, extracting by composite solvents and regulating the pH (potential of hydrogen) value to remove micromolecules in fermentation liquor and by means of nanofiltration, ion exchange, column chromatography and recrystallization, and the product purity is above 98% by testing so that the product can satisfy the demands of the pharmaceutical industry. The mupirocin purification method has the advantages of advanced technology, simple process, high yield, low cost, high mupirocin purity and the like, and is beneficial to improvement of production technology and industrialization level of the mupirocin in China.
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Description

1. Technical field

[0001] The invention belongs to the field of biotechnology, in particular to a method for purifying mupirocin. 2. Background technology

[0002] Mupirocin, also known as pseudomonosporic acid A (pseudomonic acid A), bactroban, BRL4910A, is a naturally occurring broad-spectrum antibiotic, produced by immersion and fermentation of Pseudomonas fluorescens, and has a special structure. No other antibiotics were associated. Such substances produced by Pseudomonas fluorescens include pseudomycin acids A, B, C, and D. Pseudomonas A is its main active part, accounting for 90-95%. Mupirocin is a competitive inhibitor of isoleucyl t-RNA synthetase in bacteria, which inhibits protein synthesis. The isoleucine transfer ribonucleic acid cannot be formed, so the isoleucine cannot be transported to the ribosome and transferred to the growing protein chain, resulting in the stop of protein synthesis. It can achieve and maintain a high drug concentration on the surface...

Claims

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